SHP-1
Novel sorafenib analogues induce apoptosis through SHP 1 dependent STAT3 inactivation in human breast cancer cells
... Female NCr athymic nude mice (four to six weeks of age) were obtained from the National Laboratory Ani- mal Center (Taipei, Taiwan, ROC). The mice were housed in groups and maintained in a specific pathogen free ...
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Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
... Furthermore, SHP-1 has been reported to be in- volved in regulation of other cells of the immune ...of SHP-1 with aging and a defective protection against apoptosis in these cells which were ...
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Pircher, Elisabeth (2019): Die endotheliale Tyrosinphosphatase SHP-1 spielt eine wichtige Rolle für die vaskuläre Hämostase in TNFα-induzierter Inflammation in vivo. Dissertation, LMU München: Medizinische Fakultät
... Bedingungen (d. h. ohne vorherige Stimulation mit TNFα) zu einem signifikant beschleunigten thrombotischen Gefäßverschluss in den Arteriolen der Rückenhaut. Dieser Effekt war in TNFα- induzierter Inflammation noch ...
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<p>Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway</p>
... Previous study demonstrated that 8-Bromo-7-methoxy- chrysin could inhibit the stemness of CSLCs derived from SMMC-7721 cells by blocking the STAT3/Twist axis. 28 Many studies have found that SHP-1 tumor ...
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src homology 2 domain–containing tyrosine phosphatase SHP 1 controls the development of allergic airway inflammation
... (13). SHP-1 downregulates TCR-induced acti- vation by dephosphorylating src-family PTKs, such as Lck and Fyn (28), as well as ZAP-70 kinase (29, ...of SHP-1 ...
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Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/ SHP-1-independent pathway of attenuation of Ca 2+ signal in B cells
... inhibit SHP- 1 binding to CD22 [16-18, ...for SHP-1 [19, 20]. In addition to SHP-1, ITIMs also recruit signaling molecules such as SHP-2, SHIP (an inositol ...
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Modulation of Macrophage Infiltration and Inflammatory Activity by the Phosphatase SHP-1 in Virus-Induced Demyelinating Disease
... previously, SHP-1-deficient mice do not display the typical biphasic TMEV-induced disease characterized as an acute gray-matter disease followed by chronic white-matter demyelination (56, ...of ...
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Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
... of diabetic complications, 3 initiation of intensive glycemic control after periods of poor glycemia did not decrease the rate of progression of retinopathy and other microvascular diseases significantly, suggesting ...
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Inhibitory roles for SHP 1 and SOCS 3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor
... show SHP-1 to be associated with the LIF-stimu- lated JAK2-STAT3 ...between SHP-1 and JAK2 is apparently independent of LIF stimulation, interaction between SHP-1 and STAT3 is ...
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SHP 1 phosphatase activity counteracts increased T cell receptor affinity
... inhibit SHP-2 activity as well (26). Following pharmacological inhibition of SHP-1/SHP-2, increased degranu- lation potential (Figure 7, A and B) was found within the whole T cell panel, ...
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Expression of SHP-1 and SOCS6 in patients with acute leukemia and their clinical implication
... to the manufacturer’s instructions. The quality of RNA was measured by the ratio of OD260/OD280. RNAs with ratio in the range of 1.6–2.0 were considered as high-quality RNA samples. The cDNA was synthesized by reverse ...
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Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity
... the SHP-1/2 inhibitor. Only the combination of the SHP-1/2 inhibitor with either the PTEN inhibitor or the SHIP-1 inhibitor induced striking Akt phosphorylation in MoDC and TADC ...
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Critical Role for Protein Tyrosine Phosphatase SHP-1 in Controlling Infection of Central Nervous System Glia and Demyelination by Theiler's Murine Encephalomyelitis Virus
... ons (9, 38, 42). One possibility is that increased induction of STAT1 enhances the expression of proapoptotic genes (22), which may increase virus replication in the CNS, as recently described for Sindbis virus ...
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Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer
... mediating SHP-1 activity [26, ...inducing SHP-1 expression in gastric cancer, including multiple kinase and other natural ...that SHP-1 may play a pivotal role in downregulating ...
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Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2
... of SHP-1 in trastuzumab resis- tance of breast cancers, stable SHP-1 overexpressing SKbr-3 cells were established through retrovirus ...of SHP-1 in the regulation of trastuzumab ...
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HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism
... FIG 8 Proposed mechanism of HoxA10-mediated inhibition of HBV replication. (Left) HBV life cycle. HBV virions enter the cell through the sodium taurocholate cotransporting polypeptide (NTCP) receptor and release ...
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Intravenous immunoglobulin suppresses IL 10 production by activated B cells in vitro
... of SHP-1 and SHIP, splenic B2 cells were incubated with Alexa Fluor488-conjugated human IgG (10 mg/ml) instead of IVIg for 30 min at 4˚C, and treated with CpG and/or anti-human IgG for 10 min at ...
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Regorafenib (Stivarga) pharmacologically targets epithelial- mesenchymal transition in colorectal cancer
... of SHP-1 and E-cadherin in CRC tissues and then investigated the clinical associations between SHP-1, E-cadherin and the clinicopathological parameters in CRC ...Table 1, neither ...
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Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 inregulating T cell homeostasis
... inhibitory phosphatases in response to TCR triggering. For example, PTPN6 (SHP-1) expression is upregulated upon T cell stimulation and may act to coun- teract responses to high affinity Ags. 24 We ...
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The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase 1 and Notch signaling
... Physiological angiogenesis depends on the highly coordinated actions of multiple angiogenic regulators. CCN1 is a secreted cysteine-rich and integrin-binding matricellular protein required for proper cardiovascular ...
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