Sialidase activity
Sialidase Activity of Influenza A Virus in an Endocytic Pathway Enhances Viral Replication
... The sialidase activities of all viruses tested were detected with EEA1 in early endosomes of cells after 5 min of virus ...the sialidase activity of WSN-Tx68NA or WSN-CHKNA was not observed in any ...
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Influenza A Viruses Lacking Sialidase Activity Can Undergo Multiple Cycles of Replication in Cell Culture, Eggs, or Mice
... of sialidase-independent virus CK2-29. To de- termine whether sialidase activity (including an exogenously added one) is an absolute requirement for influenza virus rep- lication, we serially ...
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Inhibition of sialidase activity and cellular invasion by the bacterial vaginosis pathogen Gardnerella vaginalis
... produces sialidase enzyme to cleave terminal sialic acid residues from human ...high sialidase activity is associated with preterm birth and low ...the sialidase inhibitor Zanamavir against GV ...
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Amino Acids Responsible for the Absolute Sialidase Activity of the Influenza A Virus Neuraminidase: Relationship to Growth in the Duck Intestine
... enzymatic activity, comparable to that found to be associated with avian virus ...specific activity for ...NA activity to a region containing six amino acid substitutions in A/England/12/62: ...
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Inhibition of sialidase activity as a therapeutic approach
... novel sialidase inhibitors is an urgent task of modern medicine accentuated by the need for treatment of constantly evolving and adapting influenza ...occurring sialidase inhibitors, further emphasizing the ...
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An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae
... ABSTRACT The pandemic potential of influenza A viruses (IAV) depends on the infectivity of the host, transmissibility of the virus, and susceptibility of the recip- ient. While virus traits supporting IAV transmission ...
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Structural characterization of the carbohydrate binding module of NanA sialidase, a pneumococcal virulence factor
... into the central nervous system (CNS), even with little contribution of the sialidase activity [10]. However, it is still not completely clear which receptor in the hBMECs is important for this process, and ...
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Biological and Protective Properties of Immune Sera Directed to the Influenza Virus Neuraminidase
... HI activity of anti-NA antibodies led us to hypothesize that these antibodies would also be able to interfere with the binding of influenza viruses to cellular ...Interestingly, sialidase activity of ...
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Serological Response to Pasteurella multocida NanH Sialidase in Persistently Colonized Rabbits
... extracellular sialidase activity, which is believed to augment colonization of the respiratory tract and the production of lesions in an active ...unique sialidase genes, nanH and nanB, that encode ...
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Genetic and functional characterization of the NanA sialidase from Clostridium chauvoei
... To express enzymatically active recombinant NanA, we amplified the part of the nanA gene from nt position 364 to 2316 (corresponding to aa 122 to 772), encoding CBM40 (sialic acid binding module) and the enzymatically ...
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Desialylation is associated with apoptosis and phagocytosis of platelets in patients with prolonged isolated thrombocytopenia after allo-HSCT
... The sialidase NEU1 was over-expressed from mRNA to protein levels, and its catalytic activity was increased in platelets from the PT ...the sialidase activity on platelets and could protect 20 ...
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Leukocyte Inflammatory Responses Provoked by Pneumococcal Sialidase
... other sialidase-expressing pathogens could boost the initial localized in- nate immune response; however, the same processes during severe infections could provoke widespread dysregulation of inhibitory Siglec ...
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Mechanisms of the action of povidone iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities
... possessing sialidase activity that cleaves sialyl link- ages between viral HA and cellular receptors to release progeny viruses and separate viruses from HA-mediated self-aggregation, allowing the virus to ...
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Novel sialic acid derivatives lock open the 150 loop of an influenza A virus group 1 sialidase
... 1 sialidase activity by locking open the flexible ...the sialidase glycoprotein that convey resistance to oseltamivir (2) and reduced sensitivity to zanamivir ...
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PREVALENCE OF COMMON TYPES OF VAGINAL INFECTIONS AMONG WOMEN ATTENDING GYNAECOLOGY CLINICS IN EGYPT
... enzyme sialidase, causes adverse obstetric and gynaecological outcomes when it is produced by BV associated ...flora. Sialidase activity may act to remove sialic acids from cervical mucins and ...
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Structural studies on the sialidases from Streptococcus pneumoniae and Pseudomonas aeruginosa
... studied sialidase in ...maximum sialidase activity, which are pH ...powerful sialidase in cleaving 3SL compared to other bacterial sialidases such as VCNA and NanI (Roggentin et ...The ...
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Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma
... a sialidase assay on the live cells as previously described ...induced sialidase activity. This sialidase activity is revealed in the periphery surrounding the cells using a fluorogenic ...
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Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited
... (PMN) sialidase activity was important in leukocyte trafficking to inflamed sites and that antibodies to Clostridium perfringens NA recognized a cell surface mole- cule(s), presumed to be a sialidase ...
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Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation
... codon. Sialidase and alpha-galactosidase NEW3 (A-galactosidase_NEW3) domains are depicted as light and dark gray boxes, ...(C) Sialidase activity of SiaBb2-truncated ...
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Influenza-specific antibody-dependent phagocytosis
... IAV. Sialidase treated THP-1 cells (5x10 5 cells) and untreated A549 cells (~5x10 5 cells, a respiratory cell line supportive of influenza infection) were infected with PR8 virus ...ADP activity in the ...
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