Sigma-1 receptor
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
... receptors 1 and 2, and despite research efforts, its specific targets remain to be fully ...Notably, sigma 1 receptor ( σ 1R) antagonists inhibit glutamate N -methyl-D-aspartate acid ...
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Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity?
... The sigma-1 receptor (sigma-1R) is an endoplasmic reticulum (ER) transmembrane protein [8] highly expressed in spinal MNs [9-11], and specially enriched in postsynaptic sites of C-terminals ...
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Successful treatment of chronic knee pain following localization by a sigma-1 receptor radioligand and PET/MRI: a case report
... The sigma-1 receptor (S1R), an inter-organelle signal modulator located predominantly in the endo- plasmic reticulum membrane, is widely distributed in the central nervous system and in peripheral ...
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Sigma-1 Receptor Regulates Early Steps of Viral RNA Replication at the Onset of Hepatitis C Virus Infection
... Hepatitis C virus (HCV) genome replication is thought to occur in a membranous cellular compartment derived from the endo- plasmic reticulum (ER). The molecular mechanisms by which these membrane-associated replication ...
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Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study
... the sigma-1 receptor ...plasma sigma-1 receptor concentration is lower in patients with MDD than in control ...26 Sigma-1 receptor ...
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Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression
... Total RNA was extracted with Trizol reagent (Invitrogen, Carlsbad, USA) according to the manufacturer’ s instruc- tions. RNA concentration and purity were assessed by OneDrop OD-1000+ spectrophotometer (OneDrop, Nan- ...
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Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa
... The rd10 model first undergoes autonomous rod degeneration and then cone death triggered by dying rods [25]. While Caspase-mediated apoptosis is known to be the major mode of rod death, mecha- nisms underlying cone death ...
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4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies
... The reactions described below were carried out with commercially available chemicals, of reagent grade, that were used without further purification. Reagents were purchased from Sigma-Aldrich Chemical Company, St. ...
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Differential Effect on Two Immobility Responses by Chronic Administration of 1,3 di o Tolyl Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion
... -1 receptor gene encodes 25 kDa membrane proteins that have no homology to any mammalian protein ...[37]. Sigma-1 receptors are intracellular receptors mainly localized on the endoplasmic ...
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OPIPRAMOL VERSUS ESCITALOPRAM IN THE TREATMENT OF GENERALIZED ANXIETY DISORDER
... sites. Sigma-1 receptor modulates calcium ion channels leading to the release of neurotransmitters, the dopamine and 5HT which in-turn results in the improvement of GAD ...
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Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent
... A sigma-1 receptor binding assay was performed using the following method. Rat cerebral membranes (465- to 1,193-μg protein) were incubated with 5-nM (+)-[ 3 H]pentazocine and various concentrations ...
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Validation of Sigma I Receptor Occupancy with Antipsychotic Ligands: A Molecular Perspective
... of sigma-1receptor with synthesized antipsychotic spiropiperid- ine derivatives through caspase assay and DNA fragmentation ...and 1, ...the sigma-1 receptor that is proposed to be ...
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PubMedCentral-PMC4912403.pdf
... behaviors. Sigma-1 receptors are expressed in limbic structures including the dentate gyrus and pyramidal cell layer of the hippocampus, superficial layers of the cortex, amygdala, basal forebrain nuclei ...
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pcp nmda not sigma1 pdf
... the sigma 1 receptor antagonists NE- 100 and BMY-14802 on the discriminative stimulus effects of PCP, dizocilpine and ( +)-SKF-10047 were also investigated ...
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SIGMA: Bulletin of European statistics No 1 January-February 1994
... They must not assume that sound official statistics can be achieved quickly, at little cost, and with no planning.' 2 THE PLAN The main points of the joint declaration signed in Brussels[r] ...
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S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands
... basic center). A histogram distribution of these com- puted physicochemical properties for the compounds in the database is presented in Fig. 2. For alignment of the key druglike attributes, the central nervous system ...
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Studies on the cell binding properties of the reovirus [sigma]1 protein
... type 1 gene that had been cloned into an SV40 based expression ...s 1 -1 transcripts with a 5' untranslated sequence longer than authentic sl-1 mRNA as a consequence of the method of ...
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SIGMA: Bulletin of European statistics No 1 January/February 1992
... This publication may be obtained free of charge from Eurostat Statistical Office of the European Communities Bureau d'information Bâtiment Jean Monnet L-2920 Luxembourg Eurostat: a quali[r] ...
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SIGMA: Bulletin of European statistics No 1 January/February 1993
... Main topics If we look at the Community work programme for environmental statistics for 1993-97, we ought to note in particular: • organization of statistical surveys on waste, based on [r] ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... Electrospray Ionization Mass Spectrometry—SDS-PAGE-sepa- rated proteins were visualized with mass spectrometry-compatible silver staining (42), excised, and in-gel digested using a robotic sys- tem as described ...
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