Signal peptidase
Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus
... by signal peptidase was < 25% that observed for the wild-type preproVP, resulting in the formation of a predominant glycosylated but uncleaved 23-kD ...
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Influenza C Virus CM2 Protein Is Produced from a 374-Amino-Acid Protein (P42) by Signal Peptidase Cleavage
... by signal pepti- dase after either Ser residue 254 or Ala residue 259, yielding ...for signal peptidase were both ...for signal peptidase cleavage were removed, respec- ...by ...
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Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin
... N-terminal signal peptide (green cylinder) securing them to the cytoplasmic membrane and the lipoprotein domain (green square) in the ...and signal peptidase II, LspA, to remove the signal ...
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Signal Peptidase Cleavage at the Flavivirus C-prM Junction: Dependence on the Viral NS2B-3 Protease for Efficient Processing Requires Determinants in C, the Signal Peptide, and prM
... authentic signal peptidase cleavage of prM generated from the C protein charge variant constructs was not verified by NH 2 -terminal sequence analysis ...influence signal peptidase cleavage at ...
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A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase
... I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly ...aureus signal peptidase can be ...
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Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase
... Shi X, Brauburger K, & Elliott RM 2005 Role of N-linked glycans on Bunyamwera virus glycoproteins in intracellular trafficking, protein folding, and virus infectivity.. Bowden TA, et al.[r] ...
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Mutagenesis of the Signal Sequence of Yellow Fever Virus prM Protein: Enhancement of Signalase Cleavage In Vitro Is Lethal for Virus Production
... prM signal peptide was substituted with residues which conform to an idealized signal ...increased signal peptidase cleavage of prM during expression of the YFV structural polyprotein region ...
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The PDZ domain of the SpoIVB serine peptidase facilitates multiple functions
... normal signal se- quence, it is probably not released by signal peptide cleavage from the membrane and, instead, releases itself by self-cleav- age, which can occur in ...secretory signal sequence ...
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Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation
... Hepatitis C virus (HCV) core protein has shown to be localized in the detergent-resistant membrane (DRM), which is distinct from the classical raft fraction including caveolin, although the biological significance of the ...
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A novel strategy to improve protein secretion via overexpression of the SppA signal peptide peptidase in Bacillus licheniformis
... release. Signal peptides play an important role in protein secretion, these peptide sequences are cleaved from the mature protein by signal peptidase I during the late stage of the secretion ...
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Dipeptidyl Peptidase-IV Inhibitors: Pharmacological Profile and Clinical Use
... A decade and a half ago, the choice of an oral antihypergly- cemic agent for any particu- lar patient was in some ways a debate of nuance. Sulfonylureas (SUs) were the only class available, and provid- ers were left to ...
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PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast
... 1N0K) after 2 days (Fig. 3D). The number of 1N0K cells increased from 16% on day 2 to 46% on day 4, after RNAi induc- tion. This increase in akinetoplastic cells suggests that PNT1 is involved in the maintenance of the ...
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Inhibition of dipeptidyl peptidase IV by fexofenadine: Virtual screening study
... Dipeptidyl peptidase-IV (DPP IV) is a protease responsible for in vivo inactivation of several endogenous peptides including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 ...
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“Synthesis of Potential Agents for the Therapy of Type 2 Diabetes Mellitus Based on Thietane 2-bromoimidazole-4,5-dicarboxylic acid Derivatives” by Ferkat Khaliullin, Anfisa Valieva, Alexander Spasov, Valentina Kuznetsova, Andrey Raschenko, Denis Babkov, Russia.
... Thietane containing 2-bromoimidazo[4,5-d]pyridazine-4,7(5Н,6Н)-diones and 2-bromo-1-(thietan-3-yl)-, 2-bromo-1-(1-oxothietan-3- yl)-, and 2-bromo-1-(1,1-dioxothietan-3-yl)imidazole-4,5-dicarboxyic acid hydrazides and ...
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Trypsin like serine peptidase profiles in the egg, larval, and pupal stages of Aedes albopictus
... of peptidase expression has been observed, particularly in adults of ...other peptidase classes were detected under the condi- tions used here, we cannot rule out the possibility ...
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Distribution of Dipeptidyl Peptidase IV in Patients with Chronic Tonsillitis
... dipeptidyl peptidase IV (DPP IV [also known as CD26]; EC ...costimulatory signal (4) mediated via coassociation with the surface tyrosine phos- phatase CD45 ...
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PEPTIDASE ACTIVITY IN HUMAN SERUM FOLLOWING BONE FRACTURE
... Moritz 8 states that the reactive inflammation with exudation begins "soon after the injury has been sustained and reaches its maximum between ten days and two weeks." From experiments c[r] ...
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Navigating the chemical space of dipeptidyl peptidase-4 inhibitors
... Abstract: This study represents the first large-scale study on the chemical space of inhibitors of dipeptidyl peptidase-4 (DPP4), which is a potential therapeutic protein target for the treatment of diabetes ...
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Regulation of dipeptidyl peptidase 4 production in adipocytes by glucose
... (F) Adipocytes obtained from high-fat diet-fed mice fed for 4 weeks were incubated in 5.5 (closed columns) or 25 mM glucose (open columns), and intracellular and released DPP4 levels we[r] ...
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Dipeptidyl Peptidase 10, a Novel Prognostic Marker in Colorectal Cancer
... percentage of stained tumor cells. Staining intensity was classified as 1 for weak, 2 for moderate, or 3 for strong staining. H scores ranged from 0 to 300. Then, in order to determine a cutoff value of H score, ...
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