signaling pathway
Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened
... Hh signaling pathway has proven to be an essential key player in tumor initiation and/or progression to more advanced tumor ...Hh signaling pathway are by far the GLI transcription factors for ...
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Role of the NFκB-signaling pathway in cancer
... of signaling pathways is involved in tumor pathogenesis and plays critical roles in growth, progression, and relapse of ...oncogenic signaling have improved the outcomes of cancer ...important ...
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Arsenic abrogates the estrogen-signaling pathway in the rat uterus
... estrogen signaling pathway and consequently lead to reproductive ...estrogen signaling pathway and the G1 cell cycle proteins responsible for cell ...
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Progress of Research on Spatzle and Toll Signaling Pathway in Insects
... multiple signaling pathways to induce the expression of antimicrobial peptides ...Toll signaling pathway is the most actively studied signaling ...Toll pathway of the immune ...Toll ...
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Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance
... cell signaling pathways, including phosphoinositide 3 kinase (PI3 K)/Akt, extracellular signal-regulated kinase (ERK)1/2, Notch, and Wnt-β-catenin, have been identi- fied to be involved in osteosarcoma ...
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The role of HGF/c-MET signaling pathway in lymphoma
... (cHL) [30], the expression of c-MET was detected in the tumor cells from 38 to 52% of the patients, and the ex- pression of HGF was found in 8% of the patients [42, 43]. The c-MET expression is positive in L428, L1236, ...
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Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
... TOR signaling pathway have provided invaluable insights into the regulation and function of this ...TOR signaling is an extensively studied pathway, the majority of studies done were on the ...
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Targeting TGFβ signaling pathway in fibrosis and cancer
... factor-β pathway which directly regulate the expression levels of several fibrous proteins such as collagen type I, collagen type III and alpha-smooth muscle ...this signaling pathway could serve as ...
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Therapeutic potential of hedgehog signaling pathway agonist
... (Hh) signaling pathway plays an integral role incorrect tissue patterning of a variety of different cell types during embryonic ...Hh pathway in the central and peripheral nervous systems, the ...
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Modulation of the canonical Wnt signaling pathway in bone and cartilage
... To be able to mechanistically analyze the role of Apc in the regulation of SPC dif- ferentiation into chondrocytes and osteoblasts, we next knocked down the mouse Apc gene using RNA interference (RNAi) in the murine ...
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Role of canonical Hedgehog signaling pathway in liver
... Hh signaling pathway activation, such as, pitchfork (Pifo), the G protein-coupled receptor associated sorting protein 2 (Gprasp2) and Growth Arrest Specific 8 (Gas8) are essential components of an Hh ...
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The Logic of Receptor Ligand Interactions in the Notch Signaling Pathway
... Notch signaling pathway enables neighboring cells to coordinate developmental fates in diverse processes such as angiogenesis, neuronal differentiation, and immune system ...Notch pathway are known, ...
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Comprehensive molecular characterization of the hippo signaling pathway in cancer
... Hippo pathway activity to understand the associated biological ...(TNF-a) signaling, inflammatory response, angiogenesis, and more, whereas the negatively correlated pathways included fatty amino acid ...
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BLM promotes the activation of Fanconi Anemia signaling pathway
... The effective repair of DNA damage, caused by exogenous agents or during DNA replication, confers protection from neoplastic transformation. Several genetic disorders that perturb the repair of DNA damage result in an ...
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Potential Role of Hippo Signaling Pathway in Gastric Cancer
... Hippo signaling pathway has been demonstrated to play a central role in the development and regulation of tissues and organ ...Hippo signaling leads to a concurrent combination of uncontrolled ...
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Review Article Signaling pathway and molecular subgroups of medulloblastoma
... Whole genome sequencing has indicated that WNT tumors have a relatively high mutation rate compared to other subgroups, and gene mutation is appeared in a WNT-enriched man- ner [62, 64, 72, 74]. For instance, mutation ...
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Reconstitution of a chemical defense signaling pathway in a heterologous system
... The long-term goal of this study was to identify a gene encoding a receptor whose ligand acts as a chemical defense in a marine organism, by functionally screening a fish cDNA library, in order to investigate the ...
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The hippo signaling pathway: implications for heart regeneration and disease
... this signaling pathway ...Hippo signaling in the fly ...Hippo pathway loss-of-function mutants, as well as dysregulation of Hippo phosphorylation and Yorkie target gene expression ...Hippo ...
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Suppression of Coronavirus Replication by Inhibition of the MEK Signaling Pathway
... The inhibitory effect of UO126 on the MHV life cycle was further investigated in the present study. Our data showed that treatment of cells with UO126 suppressed virus propagation at the step of viral RNA synthesis, but ...
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The Role of CXCL12-CXCR4 Signaling Pathway in Pancreatic Development
... The CXCL12-CXCR4 signaling pathway has key roles in the vascular formation. Cxcl12 or Cxcr4 mu- tant embryos die before birth. And there are defects in the vasculature of the gastrointestinal and nerve sys- ...
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