Sinusoidal endothelial cells
Liver sinusoidal endothelial cells and liver regeneration
... liver sinusoidal endothelial cells (LSECs) contribute to liver regenera- tion, demonstrating that hepatic stellate cells serve as the major source of HGF in normal liver but that after liver ...
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Nanocapsule delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice
... Liver sinusoidal endothelial cells are a major endogenous source of Factor VIII (FVIII), lack of which causes the human congenital bleeding disorder hemophilia ...liver sinusoidal ...
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Antagonism of RNase L Is Required for Murine Coronavirus Replication in Kupffer Cells and Liver Sinusoidal Endothelial Cells but Not in Hepatocytes
... liver sinusoidal endothelial cells (LSEC) was adapted from previously described methods ...and cells were dissociated from Glisson’s capsule in preservation buffer (NaCl ...The cells ...
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Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo
... liver cells play a predominant role in the pathophysiology of hepatic fibrosis has not been firmly established in ...hepatocytes, sinusoidal endothelial cells, and lipocytes from normal and ...
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Liver Sinusoidal Endothelial Cells Are a Site of Murine Cytomegalovirus Latency and Reactivation
... hematopoietic cells of the myeloid lineage are a recognized source of latent CMV, the cellular sites of latency in the liver are not comprehensively ...Y-chromosome-negative cells of recipients’ ...ⴙ ...
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Original Article SK-Hep1: not hepatocellular carcinoma cells but a cell model for liver sinusoidal endothelial cells
... SK-Hep1 cells, indicating high and rapid endocytic ...SK-Hep1 cells and was consistent with a virally transformed immortal LSEC line ...SK-Hep1 cells are able to take up FITC-FSA [10], no ...
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Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids
... the sinusoidal microvascula- ture that lies between these sites ...the sinusoidal lumen and thus mediate blood flow. Although SEC, Kupffer cells, and HSC all possess contractile proteins (54), ...
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A new reporter mouse cytomegalovirus reveals maintained immediate early gene expression but poor virus replication in cycling liver sinusoidal endothelial cells
... some cells showed polarized expression of tdTomato or YFP (Figure ...same cells in a kinetic fashion. Interestingly, the majority of infected cells lived longer than 96 h, and cell death could be ...
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Cell specific expression of hepatocyte growth factor in liver Upregulation in sinusoidal endothelial cells after carbon tetrachloride
... in sinusoidal endothelial and Kupffer ...in endothelial cells. HGF mRNA levels rose sixfold in these cells, peaking at 6 h after toxin administration and returning to near normal by 24 ...
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MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis
... To ascertain which mediator(s) might be released from HHSECs to induce CRC cell migration, we compared the culture supernatants (conditioned media) that were collected from the upper and lower chambers of the Transwell ...
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Arsenic stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide
... liver sinusoidal endothelial cells (SECs), including SEC defenestration, capillarization, increased junctional PECAM-1 expression, protein nitration, and decreased liver clearance of modified ...
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Endotoxin and CD14 in the progression of biliary atresia
... Kupffer cells and sinusoidal endothelial cells were immunostained positive and the arterial and venous endothelium, bile duct epithelial cells, and hepatocytes were ...Kupffer ...
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Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
... liver sinusoidal endothelial cells (LSECs) are thought to drive liver ...to endothelial progenitor cells, mature LSECs express little ...progenitor cells to engraft in the liver ...
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Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking
... cDC2-like cells. We identified a similar population of cDC2-like cells in human bone ...cDC2 cells, such as Cx3cr1 and Fcgr1, certain cDC1 genes are also highly expressed, such as Irf8 and Clec9a ...
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Hepatic uptake of a modified low molecular weight heparin in rats
... Thus, a scavenger receptor-mediated uptake of heparin by liver macrophages and sinusoidal endothelial cells might play an important role for the liver metabolism of both the tracer compo[r] ...
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A Reaction Diffusion Algorithm for Segmentation of Three Dimensional Sinusoidal Networks in Rats Fed a High Fat and High Cholesterol Diet: New Insights and Evaluation
... of sinusoidal endothelial ...the sinusoidal patterns of rats fed a high-fat/high-cholesterol diet were examined; these rats exhibited pathological features similar to those of human patients with ...
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Melatonin modulates the expression of Bcl 2 family proteins in liver after thermal injury in rats
... in sinusoidal endothelial cells (SECs) of burn-treated animals compared with the control group animals as well as elevated ratio Bax/Bcl-2 suggesting the sus- ceptibility of these cells to ...
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CONTINUING PHARMACY EDUCATION SERIES: HEPATOTOXICITY A REVIEW
... Although the exact mechanism of DIH remains largely unknown, it appears to involve 2 pathways — direct hepatotoxicity and adverse immune reactions. The pathogenesis of drug- induced liver injury usually involves the ...
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Advances in sepsis-associated liver dysfunction
... Recent studies have revealed liver dysfunction as an early event in sepsis. Sepsis-associated liver dysfunction is mainly resulted from systemic or microcirculatory disturbances, spillovers of bacteria and endotoxin ...
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Cell specific expression of transforming growth factor beta in rat liver Evidence for autocrine regulation of hepatocyte proliferation
... hepatocytes, sinusoidal endothelial cells, Kupffer cells (liver macrophages), and lipocytes (Ito or stellate cells) from normal and regenerating ...in sinusoidal ...
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