SK-Hep1 Cells
Effects of Mitochondrial DNA Deletion and OSW 1 on PI3K AKT Signaling Pathway PCR Array in SK Hep1 Cells
... tumor cells in the aspects of cell invasion, angiogenesis, cell polarity and cell adhesion, affects the core genes in each signaling pathway, and induces apopto- sis of hepatoma cells ...hepatoma ...
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TRAF6 Affects RAC1 Expression and Apoptosis in SK Hep1 Cells
... Effect of RAC 1 on apoptotic rate. The RAC1 siRNA was transfected into SK-Hep1 cells, and the transfection effect was detected through RT-PCR. The results show that RAC1 mRNA expression was ...
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Original Article High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma
... HCC is the most common type of liver cancer and the third leading cause of cancer death worldwide [13]. Exploring the molecular mechanism of tu- morigenesis and recurrence is extremely important for seek- ing better ...
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Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway
... Vitexin, a flavonoids compound, is known to exhibit broad anti-oxidative, anti- inflammatory, analgesic, and antitumor activity in many cancer xenograft models and cell lines. The purpose of this study was to investigate ...
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Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β catenin/T cell factor–dependent hepatocarcinogenesis
... CCRK possesses oncogenic functions in HCC. (A) Ectopic CCRK expression induced cell cycle progression in SK-Hep1 cells. β-actin was used as a loading control. (B) Focus formation assay of ...
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<p>INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma</p>
... HCC cells. For the apoptosis assays, Huh7 and SK-HEP1 cells were harvested after 48 hrs of incubation, stained with 50 μ g/mL PI and FITC and sub- sequently analyzed via fl ow ...of ...
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SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells
... tumor cells in vivo. Sk-Hep1 cells with Tet-on-GADD45G expression cassette were infected with lentiviruses carrying shRNA against SIP1 or the control shRNA, ...These cells were ...
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Effect of IRAK1 on Apoptosis and Necroptosis of Hepatoma Cell Line SK Hep1
... Different signal pathways are involved in the pathogenesis of HCC, and the in- flammatory signal pathway is closely related to the occurrence and development of HCC [12] [13]. The role of IRAK1 in different tumors has ...
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Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1 aactivity and inhibiting epithelial-mesenchymal transition
... on SK-Hep1 cell lysates using an antibody against ...in SK-Hep1 cells transfected with the CPS1-IT1 plasmid or vector ...in SK-Hep1 and HepG2 ...in SK-Hep1 ...
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Actinidia callosa var. callosa suppresses metastatic potential of human hepatoma cell SK-Hep1 by inhibiting matrix metalloproteinase-2 through PI3K/Akt and MAPK signaling pathways
... promotes SK-Hep1 cancer cell migra- tion and invasion in concert with the activation of the MAPK and PI3K/Akt signaling pathways, which modulate the MMP ...in SK-Hep1 ...
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Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis
... the cells treated with siCont or siPGCP (Supplementary Figure ...both SK-Hep1 and SNU-387 cells (Figure ...knockdown cells (Figure ...the cells treated with siPGCP showed ...
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MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway
... and SK-Hep1 cells were significantly increased after MKP-4 deple- tion, whereas overexpression of MKP-4 impaired the capacity of cell ...treated cells to grow spheres under serum-free ...HepG2 ...
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<p>Upregulation of hypoxia-inducible factor 1α mRNA expression was associated with poor prognosis in patients with hepatocellular carcinoma</p>
... transformed Sk-Hep1 cells (transfected with LV- Scramble-Sk-Hep1 or LV-ShHIF1 α -Sk-Hep1) (in a volume of 100 µl) were subcutaneously injected into the right fl ank of the ...
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Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma
... Ago2 antibody in SK-Hep1 cells. Subsequently, ChIRP assays demonstrated that there were direct interactions between SNHG12 and the miR-199a/b-5p. Eventually, SNHG12 was able to modulate the ...
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Original Article SK-Hep1: not hepatocellular carcinoma cells but a cell model for liver sinusoidal endothelial cells
... the SK-Hep1 cells, indicating high and rapid endocytic ...in SK-Hep1 cells and was consistent with a virally transformed immortal LSEC line ...Although SK-Hep1 ...
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Bi-directional roles of IRF-1 on autophagy diminish its prognostic value as compared with Ki67 in liver transplantation for hepatocellular carcinoma
... with SK-Hep1 cells, apoptosis was enhanced and autophagy reduced after IFN-γ stimulation, an effect which was accompanied with an increase in ...
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Original Article AF113014 inhibits proliferation and migration of hepatocellular carcinoma cells by binding eEF1A1 protein
... HCC cells, SK-Hep1 cells were transiently transfected with ...in SK-Hep-1 cells transfected with ...in SK- Hep-1 cells (P < ...in SK-Hep1 ...
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Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells
... cancer cells, and defects in apoptosis may result in ...(SK-Hep1 cells). In this study, a stable MDR phenotype characterization of SK-Hep1 cell line (SK-Hep1/CDDP ...
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FOXC1 Contributes To Microvascular Invasion In Primary Hepatocellular Carcinoma Via Regulating Epithelial-Mesenchymal Transition
... The existence of microvascular invasion (MVI) formation is one of the most important risk factors predicting poor outcome in hepatocellular carcinoma (HCC) and its mechanism remains largely unknown. ...
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Original Article CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma
... L02 cells and their matched adjacent normal tissues, respectively, and was strongly corre- lated with number of tumors and recurrence in clinical samples of HCC ...the cells prolif- eration, tumorigenesis ...
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