Skeletal Muscle Atrophy
Pathways of Skeletal Muscle Atrophy: HIV as a Model System?
... Skeletal Muscle Atrophy (SMA) is a phenomenon found in many diseases and disorders. SMA is characterized by protein degradation induced by various pathways. Ten years ago, little was known about the ...
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miR-628 Promotes Burn-Induced Skeletal Muscle Atrophy via Targeting IRS1
... Skeletal muscle atrophy is a common clinical feature among burn ...burn-induced skeletal muscle atrophy, we established a 30% TBSA burn model, as described in the “Material and ...
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Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy
... in skeletal muscle biology and disease ...tumor-induced muscle atrophy in mice [5, ...to skeletal muscle atro- phy [10]. Due to its importance in muscle pathology, the ...
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Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice
... Skeletal muscle atrophy involves massive loss of muscle structural proteins, which leads to muscle weight decrease and progressive loss of muscle ...function. Skeletal ...
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Transcriptional profiling to identify therapeutic targets influencing skeletal muscle atrophy
... block atrophy and the nAChR subunits were shown to increase in expression, with marked changes in the alpha and delta subunit in particular (figure ...the muscle fibre. As calcium levels drop with number of ...
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Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis
... in muscle mass in the unilateral sciatic nerve transection model over the first two ...promoted atrophy of denervated skeletal ...of skeletal muscle cells were also confirmed in C2C12 ...
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Skeletal muscle atrophy in sedentary Zucker obese rats is not caused by calpain-mediated muscle damage or lipid peroxidation induced by oxidative stress.
... level, atrophy is a well-documented conse- quence of T2D ...the muscle weights of obese Zucker rats compared to lean controls, accompanied by decreased fibre area in both fast- and slow-twitch ...Muscular ...
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The proteasome inhibitor MG132 reduces immobilization induced skeletal muscle atrophy in mice
... disuse muscle atrophy induced by unloading is associated with the activation of an alternative NF B pathway distinct from the pathway seen with cachexia where TNF a is responsible for mus- cle ...
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Overexpression of MyoD Attenuates Denervated Rat Skeletal Muscle Atrophy and Dysfunction
... of muscle is big challenge. In denervated skeletal muscle, therapid expression of MyoD mRNA and protein also occurs during early postdenervation, which suggested that the function of ...
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Original Article IL-6 improves myogenesis in long-term skeletal muscle atrophy via the JAK/STAT3 signalling pathway
... during muscle regeneration both in vitro and in vivo, whereas this function was remarkably inhibited by the application of ...long-term skeletal muscle atrophy, at least in part, via the ...
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MST1, a key player, in enhancing fast skeletal muscle atrophy
... adult skeletal muscles, we performed sciatic denervation on hin- dlimb muscles from three- to five-month-old adult wild type (WT) and MST1 knockout (KO) ...denervation-induced atrophy in fast- but not in ...
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Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice
... particularly skeletal muscle atrophy in mice with bladder ...induce muscle atrophy, mainly by increasing muscle proteolysis, or reducing protein synthesis, or both ...the ...
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Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium
... of skeletal muscle masses shown in Figure ...the skeletal muscle atrophy improved significantly is likely due to down-regulation of myostatin as well as related ...in muscle is ...
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FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension
... of muscle is sensed and translated into signals controlling tissue reduction remains a major question in the field of musculoskeletal ...of skeletal muscle atrophy associated with denervation ...
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Original Article MURF contributes to skeletal muscle atrophy through suppressing autophagy
... Skeletal muscle atrophy results from an array of conditions, such as aging, starvation, cancer, diabetes, bed rest, hormone dysfunction, and denervation ...As skeletal muscle fibers are ...
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Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old wistar rats
... aged muscle to self-repair is a key driver of this process [4,6,28,57], whether in situations of overt injury as in small daily damages not perceived via pain or altered contractile function ...of muscle ...
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TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism
... pathways were not additive, suggesting that a mere reduction in ceramide formation, rather than complete suppression, is enough to prevent cell atrophy. Alterna- tively, this could result from the overall ...
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Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation in Cyclorana alboguttata (Günther 1867)
... Whole muscle mass, water content, myofibre number and myofibre CSA remained unchanged in the gastrocnemius muscle after six to nine months of ...dry muscle mass, whole muscle CSA and myofibre ...
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Preventive effects of Chlorella on skeletal muscle atrophy in muscle specific mitochondrial aldehyde dehydrogenase 2 activity deficient mice
... in muscle-specific mitochondrial ALDH2 activity were also developed by inducing the transgenic expression of ALDH2*2 under the control of the actin promoter ...
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Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
... inflammation-induced muscle failure and increased IL-1 β levels other forms of muscle atrophy might also profit from Nlrp3/IL-1β inhibition; for example, in patients with rheumatoid arthritis and ...
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