Skeletal related events
Management of skeletal related events in patients with advanced prostate cancer and bone metastases: Incorporating new agents into clinical practice
... Skeletal-related events (SREs) are a common complication of bone metastases, and have serious negative consequences for patients with castrate-resistant prostate cancer ...
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Exploiting machine learning for predicting skeletal-related events in cancer patients with bone metastases
... to skeletal-related events (SREs), defined as pathologic fracture, spinal cord compression, requirement for radiation, surgery to bone, and hypercalcemia ...
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<p>Prevention Of Skeletal Related Events In Multiple Myeloma: Focus On The RANK-L Pathway In The Treatment Of Multiple Myeloma</p>
... Abstract: More than 90% of patients with multiple myeloma (MM) have osteolytic bone lesions which increase the risk of skeletal-related events (SRE). The cytokine milieu in the bone marrow ...
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Hospital visits among women with skeletal-related events secondary to breast cancer and bone metastases: a nationwide population-based cohort study in Denmark
... A Portuguese retrospective study on 121 women with breast cancer, bone metastases, and at least one SRE in the preceding 12 months (defined as spinal cord compression, patholog[r] ...
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Denosumab for the prevention of skeletal complications in metastatic castration-resistant prostate cancer: comparison of skeletal-related events and symptomatic skeletal events
... Patients and methods: Patients with CRPC, no previous bisphosphonate exposure, and radiographic evidence of bone metastasis were randomized to subcutaneous denosumab 120 mg plus i.v. placebo every 4 weeks (Q4W), or i.v. ...
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Hospital use among patients with lung cancer complicated by bone metastases and skeletal-related events: a population-based cohort study in Denmark
... We examined the number of inpatient hospitalizations, inpatient bed-days, hospital outpatient clinic visits, and emergency room visits within three time periods: a pre-SRE period ([r] ...
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Design and methods for a Scandinavian pharmacovigilance study of osteonecrosis of the jaw and serious infections among cancer patients treated with antiresorptive agents for the prevention of skeletal-related events
... adverse events that might surface with greater numbers of patients under observation for longer time periods than would be possible during a clinical trial ...adverse events observed during a clinical trial ...
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Health state utilities for skeletal-related events secondary to bone metastases
... or less than the sum of the two disutilities, depending on the individual patient and the unique combination of SREs. Despite the limitations, the current study is a step toward more thorough modeling of treatment for ...
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Measurement of skeletal related events in SEER-Medicare: a comparison of claims-based methods
... SRE- related data may be affected by certain parameters, such as codes and window lengths, that define the boundaries of the SRE-related observational ...
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Analgesic efficacy of zoledronic acid and its effect on functional status of prostate cancer patients with metastasis
... of skeletal- related events (SRE) (pathological fractures: vertebral or nonvertebral) and an alleviation in bone ...of skeletal events in metastatic prostate cancer ...
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Optimal management of bone metastases in breast cancer patients
... Biomarkers are a fundamental feature of the strategy of “personalizing medicine”. A biomarker assay with high sensitivity and specificity may potentially help clinicians to screen high-risk patients for bone metastases, ...
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The role of biomarkers in the management of bone-homing malignancies
... SREs, skeletal related events; BTM, bone turnover markers; P1NP and P1CP, N and C terminal pro-peptides of type 1 collagen; BALP, bone specific alkaline phosphatase; TRACP-5b, tartrate-resistant acid ...
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Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases
... for skeletal-related events (SREs), including pathologic fractures, spinal cord compression, need for palliative radiation therapy or surgery to bone, and ...SREs related to ...
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Metastatic Bone Disease - A Review of Literature
... Growth of ageing population is a recognized feature all over the world. Better living standards, availability of good medical facilities, and awareness among people are contributory to it. Many of the communicable ...
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The burden of symptomatic skeletal events in castrate resistant prostate cancer patients with bone metastases at three Canadian uro oncology centres
... cancer- related medical history, and metastatic bone disease-attributable resource ...use. Skeletal events identified through this retrospective approach were assumed to result from symptomatic ...
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Impact of abiraterone on patient-related outcomes in metastatic castration-resistant prostate cancer: current perspectives
... gesting perhaps the use of abiraterone earlier in the disease course, rather than waiting until later on when patients have worse functional status or compromised physical ability, would have better outcomes. The ability ...
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The impact of occupational hazards and traumatic events among Belgian emergency physicians
... traumatic events, life events, the occurrence of physical hazards, occurrences of violence, occurrence of situations that increase the risk of burnout and social support by supervisors and colleagues ...
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Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos
... of skeletal tissues is of particular importance in attempts to regenerate tissue for replacement therapies including therapies for patients with articular cartilage defects such as ...
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The Role of Sentinel Events in the Measurement of Work Related Stress
... The attention given to the work environment is reflected in the prominence given to phenomena such as ab- senteeism, overtime, interpersonal conflicts, complaints, letters of recall, and injury rates that are reported in ...
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Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training
... Following an unaccustomed bout of resistance exercise, increased heat shock.. protein binding was associated with a transient rise in transcripts linked to eIF2 and.[r] ...
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