Skin Toxicity
Skin toxicity evaluation in patients treated with cetuximab for metastatic colorectal cancer: a new tool for more accurate comprehension of quality of life impacts
... including skin toxicity assessment, at baseline (before starting antineoplastic treatment) and at every subsequent ...Cutaneous toxicity was evaluated using both the NCI-CTCAE ...
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Frölich, Matthias Frank (2018): The polymorphic DNA marker rs849142 predicts skin toxicity in anti-EGFR treatment of metastatic colorectal cancer. Dissertation, LMU München: Medizinische Fakultät
... The decision for targeted anti-EGFR-therapy (−EGFR) is personalized and predictive as efficacy of −EGFR therapy is limited to tumors without mutations (wild-type, WT) in the rat sarcoma (RAS) genes KRAS (Kirstin RAS) ...
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Evidence from a breast cancer hypofractionated schedule: late skin toxicity assessed by ultrasound
... late skin toxicity after breast radiotherapy also by change of skin thickness as a objective measure of the severity of ...late skin toxicity assess- ment by quantitative ...
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Synchronous BRAFV600E and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity
... Subsequently, we assessed the effect of combined BRAFi and MEKi treatment after a period of single BRAFi treatment, mimicking the clinical setting in which treatment is altered upon BRAFi escape. We analyzed tumor ...
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Daily baseline skin care in the prevention, treatment, and supportive care of skin toxicity in oncology patients: recommendations from a multinational expert panel
... of skin toxicity and use of cosmetics and nonpharmaceutical skin care products adjunctive to cur- rent cancer ...on skin, mucosal, and nail disorders following oncology treatments as well as ...
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Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial.
... acute skin toxicity substudies were not designed to involve statistical hypothesis testing across treatment groups, but to con- firm low incidence rates of clinically significant acute skin ...
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Seeing red: flushing out instigators of niacin associated skin toxicity
... as skin pain and/or itching invites misunderstand- ing at best, and diverts attention away from the real clinical problem at ...niacin-associated skin toxicity to better reflect broad pathologic ...
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Women’s experience of acute skin toxicity following radiation therapy in breast cancer
... changes were reported as Radiation Therapy Oncology Group grade 1 (faint erythema, dry desquamation) or 2 (tender or bright erythema, patchy moist desquamation) in 95% of the participants. Interestingly, physical changes ...
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SKIN TOXICITY OF TARGETED THERAPY: VEMURAFENIB, FIRST EXPERIENCES FROM MONTENEGRO
... cell skin carcinomas suggest they are more aggressive in BRAF inhibitor treated pa- tients when compared to spontaneously developed le- sions ...of skin malignancies, including p53 mutation (21) that was ...
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Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab
... (severe) skin toxicity, as previously ...inhibitor-induced skin toxicity is not completely understood and candidate gene based studies focus only on mutations and genes assumed to be involved ...
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<p>Skin Toxicity Assessment of Silver Nanoparticles in a 3D Epidermal Model Compared to 2D Keratinocytes</p>
... of toxicity in ...vivo skin microenvironment, and therefore provide limited information regarding phy- siological responses of organisms to external stimuli, such as ...
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Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
... but skin-toxicity studies focus mostly on several kinds that are most widely used in dermatology, such as AgNPs, AuNPs, ZnO NPs, and TiO 2 ...NPs. Skin-toxicity research on metallic NPs like ...
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Patient considerations in metastatic colorectal cancer – role of panitumumab
... with skin toxicity management and prevention, diligent magnesium monitoring with magnesium replacement protocols in place, and in the avoidance of acute and chronic paronychial ...
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Toxicity of Hypofractionated Radiotherapy Following Breast Conservative Surgery in Breast Cancer
... induced toxicity was ...Acute skin toxicity was assessed, and it was noted that grade 2 skin toxicity was shown in only 6 patients ...Late skin toxicity (telangectasia, ...
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ACUTE DERMAL TOXICITY AND IRRITABILITY STUDIES OF Ag2Ga NANONEEDLE MEDIATED SILVER FORMULATION AS PER OECD 402 AND 404 PROTOCOLS
... of toxicity and intended function. The variation of toxicity results for various nanostructures were reported in ...about toxicity of novel needle shaped nanostructures. Acute toxicity study ...
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Evaluation of Acute Dermal Irritation and Wound Contraction by Gymnema Sylvestre and Datura Metel Extracts in Rats
... irritancy, skin irritancy and phototoxicity ...several skin toxicity tests. Major factors correlated with toxicity are associated with amines, nitrous compounds or detrimental substances which ...
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Acute Skin and Pharynx Complications Following Adjuvant Hypofractionated Versus Conventional Radiotherapy in Patients with Breast Cancer
... Acute skin changes were examined by dermatology specialists in our ...of skin toxicity and pharyngitis were reported using “Radiation Therapy Oncology Grading” criteria 21 ...
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Acute radiation dermatitis in breast cancer patients: challenges and solutions
... A major evolution in breast radiation treatment stemmed from the discovery that techniques that deliver a more uniform, homogenous radiation dose across breast tissue result in significantly less acute and long-term ...
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Perspectives on Transdermal Drug Delivery
... Besides skin toxicity of the drug or drug excipients, the major obstacle facing this route of delivery is the barrier nature of the skin which limits the number of molecules permeating it to only few ...
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Hypofractionated radiotherapy after conservative surgery may increase low–intermediate grade late fibrosis in breast cancer patients
... increased toxicity, we opted for the use of IMRT ...subcutaneous toxicity after AHF and no differences between the two techniques in terms of late skin ...
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