Small GTPase
Ras-Dependent Cell Fate Decisions Are Reinforced by the RAP-1 Small GTPase in Caenorhabditis elegans
... C. elegans encodes RAP-1 and RAP-2, which correspond to mammalian Rap1 and Rap2, respectively (C. elegans RAP-3, which has a nonconservative change in a critical residue in the core effector binding sequence, is likely ...
16
Effects of Rho1, a small GTPase on the production of recombinant glycoproteins in Saccharomyces cerevisiae
... Rho1p small GTPase, is confirmed to partially recover the growth defect of Saccharomyces cerevisiae Δalg3Δoch1 double mutant ...Rho1p GTPase on cell wall ...
12
Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy
... the small GTPase ARF6 alters VEGFR2 trafficking and reverses signs of pathology in 4 animal models that represent features of diabetic retinopathy and in a fifth model of ocular pathological ...
15
In vivo monitoring of plant small GTPase activation using a Förster resonance energy transfer biosensor
... various small GTPases, including Rac1, Cdc42, RhoA, Ral, TC10 and Rab5 in animals [9, ...the small GTPase human Rac1, a linker, the CRIB domain of PAK, CFP, and the C-terminal polybasic region and ...
14
Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei
... Abstract: Arl6/BBS3 is a small GTPase, mutations in which are implicated in the human ciliopathy Bardet–Biedl Syndrome (BBS). Arl6 is proposed to facilitate the recruitment of a large protein complex known ...
8
Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons
... the small GTPase Arf1, an important regulator of the secretory pathway, is specifically required for dendrite pruning of ddaC/D/E sensory neurons but dispensable for apoptosis of ddaF ...
12
An Adenovirus Inhibitor of Tumor Necrosis Factor Alpha-Induced Apoptosis Complexes with Dynein and a Small GTPase
... Adenoviruses (Ad) code for immunoregulatory and cytokine regulatory proteins, one of which is the early region 3, 14.7-kDa protein (Ad E3-14.7K), which has been shown to inhibit tumor necrosis factor alpha-induced ...
5
Small-GTPase-Associated Signaling by the Guanine Nucleotide Exchange Factors CpDock180 and CpCdc24, the GTPase Effector CpSte20, and the Scaffold Protein CpBem1 in Claviceps purpurea
... plants. GTPase regulators contribute to the nucleotide loading cycle that is essential for proper functionality of the ...gather GTPase complexes to facilitate proper ...activate GTPase signaling by ...
13
High expression of small GTPase Rab3D promotes cancer progression and metastasis
... Rab GTPases control exocytic and endocytic membrane trafficking such as exosomes release. As a secretory small GTPase, Rab3D is a vital regulator for protein secretion. However, the role of Rab3D in cancer ...
14
<p>RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer</p>
... Regulator of chromosomal condensation 2 (RCC2), also known as TD-60, has been found to be required for the maintenance of the normal cell cycle. 4,5 Recently, it has been shown that RCC2 is frequently overexpressed, and ...
11
A Role for the Small GTPase Rab6 in Assembly of Human Cytomegalovirus
... the small GTPase Rab6 that links Rab6 activity to dynein ...Rab6 GTPase through its C-terminal domain and to dynein through its N-terminal domain and colocalizes with Rab6 in the trans- Golgi network ...
7
C elegans Rab GTPase activating protein TBC 2 promotes cell corpse degradation by regulating the small GTPase RAB 5
... a small GTPase, the role of RAB5 as a molecular switch relies on it oscillating between inactive GDP-bound and active GTP-bound states, which is coordinated by guanine nucleotide exchange factors (GEFs) and ...
11
The Small GTPase Rsg1 is important for the cytoplasmic localization and axonemal dynamics of intraflagellar transport proteins
... Our lab has also shown that Fuz binds the putative small GTPase, Rsg1, and that loss of Rsg1 results in ciliogenesis phenotypes. Given the defective cytoplasmic localization of IFT upon loss of Fuz and the ...
11
Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling
... In conclusion, our data provides evidence that the small GTPase Arl6 contributes to RMS cell growth due to its function in ciliogenesis and ciliary Hh signaling. While Hh signal induces the transcription of ...
11
The Ancient Small GTPase Rab21 Functions in Intermediate Endocytic Steps in Trypanosomes
... TbRab21 is expressed in trypanosomes at very low levels, which suggested that either genomic tagging or production of an- tibodies was unlikely to be informative, in terms of localizing the gene product or estimating ...
16
Serotonin improves glucose metabolism by Serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells
... Recently, several studies showed a novel mechanism of protein activation by covalent binding of 5-HT to a num- ber of intracellular proteins after entering the cell through the 5-HT-reuptake transporter (SERT). This ...
9
Interaction of the Small GTPase Cdc42 with Arginine Kinase Restricts White Spot Syndrome Virus in Shrimp
... (1). Small GTPases possess a common, structurally preserved GTP-binding domain and form an independent superfamily containing proteins that control a vast number of important processes, including growth, cellular ...
17
Regulation of small GTPase function during phagocytosis
... et al., 1996). They comprise a consensus sequence termed the Cdc42/Rac-interactive binding (CRIB) motif, which is commonly found in many Cdc42/Rac effectors and is necessary but not sufficient to direct GTPase ...
184
The small GTPase RhoH is an atypical regulator of haematopoietic cells
... The C-terminus of Rho GTPases has a function in mediat- ing interactions with the membrane through its polybasic motif and more importantly, by the CaaX motif. Figure 1 shows the basic residues in bold printing and the ...
13
Regulation of localization and function of the Rho family small GTPase, Rnd3
... mediated post-prenyl processing for the membrane association and function of nonclassical Rho proteins. Through the use of CAAX-specific mutations I found that full processing (prenylation, along with –AAX cleavage and ...
207