Small GTPases
Insights into the classification of small GTPases
... of small guanosine triphosphate proteins (GTPases) to specific ...subgroups. Small GTPases represent an important functional group of proteins that serve as molecular switches in a wide range ...
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Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress
... Shear stress has been implicated in pathophysiological processes in the vascular wall such as atherosclerosis, reperfusion, and EC wound healing (1–8). Because both Cdc42 and Rho are sensitive to the applied shear ...
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Structure function analyses of the interactions between Rab11 and Rab14 small GTPases with their shared effector Rab coupling protein (RCP)
... Rab GTPases recruit effector proteins, via their GTP-depen- dent switch regions, to distinct subcellular ...related small GTPases that bind to common effectors termed the Rab11 family of interacting ...
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Ras dva, a member of novel family of small GTPases, is required for the anterior ectoderm patterning in the Xenopus laevis embryo
... of small GTPases, we aligned four of them (by one from each Gallus gallus, Xenopus tropicalis, Danio rerio, Takifugu rubripes) with 19 amino acid sequences of small GTPases, belonging to all ...
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Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae
... ABSTRACT The GPN proteins are a poorly characterized and deeply evolutionarily conserved family of three paralogous small GTPases, Gpn1, 2, and 3. The founding member, GPN1/NPA3/XAB1, is proposed to ...
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Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain
... of small GTPases and are im- plicated in the regulation of a variety of cellular phe- nomena including proliferation, adhesion, polarity and endocytosis ...of small GTPases by catalyzing the ...
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Involvement of Botrytis cinerea Small GTPases BcRAS1 and BcRAC in Differentiation, Virulence, and the Cell Cycle
... a small number of previous reports that hint at an association between RAC and the cell cycle: in the dimorphic fungus ...RHO-type small GTPases, BcCDC42 and BcRAC, seem to have opposite effects on ...
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MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial- mesenchymal transition in breast cancer
... Epithelial-mesenchymal transition (EMT) is one of the decisive steps regulating cancer invasion and metastasis. However, the molecular mechanisms underlying this transition require further clarification. MDA-9/syntenin ...
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Spatial regulation of exocytosis by Rho family small GTPases in Saccharomyces cerevisiae
... these GTPases produced in ...all small GTPases are subjected to post-translational modifications which do not occur following expression in ...
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Targeted Quantitative Proteomic Profiling of Small GTPases in Cultured Cells and Tissues
... expressed small GTPases in breast cancer by performing Kaplan–Meier survival analysis for significantly up- and down-regulated proteins shown in Figure ...
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Vascular endothelial growth factor (VEGF) regulation of endothelial cell behavior through the Rho family of small GTPases
... Rho GTPases, whereas some GEFs are more promiscuous so they activate multiple GTPases depending on the upstream ...Rho GTPases by GEFs has been shown to stimulate translocation of these proteins ...
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Gluten quality of bread wheat is associated with activity of RabD GTPases
... Rab GTPases in the endosperm of hexaploid wheat could be further exploited to better under- stand, and possibly improve, the technological properties of ...RAC/ROP small GTPases, the authors of the ...
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Biophysical Investigations of the Specificity between Rab GTPases and their Effectors
... first GTPases to be discovered were those which aid initiation, elongation and termination of translation and the seven transmembrane receptors, followed by the Ras small GTPases [11, ...
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Structural biology of arf and rab GTPases' effector recruitment and specificity
... of small GTPases, the C terminus of switch 1 and the N terminus of switch 2 are brought into spatial proximity with the g-phosphate of GTP via conserved hydrogen ...
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The role of Rac GTPases in B cell development and activation
... The B cell developmental abnormalities noted in the Æac-deficient mice analysed required more mechanistic inquiry to uncover why deficiency in Rac2 and also Racl had profound affects on the generation and/or survival of ...
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Ras family GTPases involved in breast cancer
... The Ras branch of the Ras superfamily of small GTPases consists of over thirty-six proteins that regulate a wide array of cellular processes. Mutations in the RAS oncogene that cause aberrant activation of ...
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Rho GTPases as therapeutic targets in Alzheimer’s disease
... Rho GTPases are an important target in human diseases such as Alzheimer’s disease (AD), cardiovascular, pulmon- ary, and neurological disorders, and cancers ...Rho GTPases in AD pathogenesis have been ...
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Genetic Interactions in Yeast Between Ypt GTPases and Arf Guanine Nucleotide Exchangers
... of small GTPases, Arfs and Ypt/rab pro- 1995, ...Ypt/rab GTPases are crucial for secretion in both yeast exit from the trans-Golgi suggested a role for Ypt/rabs and mammalian ...
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Adenovirus Endocytosis Requires Actin Cytoskeleton Reorganization Mediated by Rho Family GTPases
... cortical actin fibers, as well as stress fiber formation in a large portion of the cells (Fig. 1A and G). However, the addition of Ad caused a rapid polymerization of actin within the cell, and this was associated with ...
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Rac and Rho GTPases in cancer cell motility control
... of small GTPases (RhoH) has been reported to be genetically altered in non-Hodgkin ’ s lymphomas and multiple ...Rho GTPases, accomplished by the level of expression or activation of their regulators ...
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