Small interfering RNA (siRNA) interference
Ebolavirus Proteins Suppress the Effects of Small Interfering RNA by Direct Interaction with the Mammalian RNA Interference Pathway
... EBOV has developed redundant mechanisms to counterat- tack host RNAi-based immunity. We found a third SRS, the EBOV matrix protein VP40. Preliminary experiments show that VP40 was not seen in association with siRNA ...
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RNA Interference against Animal Viruses: How Morbilliviruses Generate Extended Diversity To Escape Small Interfering RNA Control
... other RNA viruses such as enterovi- ruses and retroviruses (34 ⫻ 10 ⫺4 and 25 ⫻ 10 ⫺4 , respectively) (31) In addition to the large genomic malleability peculiar to mor- billiviruses, these considerations ...
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Functional Nanostructures for Effective Delivery of Small Interfering RNA Therapeutics
... Small interfering RNA (siRNA) has proved to be a powerful tool for target-specific gene silencing via RNA interference (RNAi). Its ability to control targeted gene expression gives new ...
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Molecular Bases of Viral RNA Targeting by Viral Small Interfering RNA-Programmed RISC
... target RNA in trans with high sequence ...of RNA interference pathways (7, 12); thus, it is a rea- sonable possibility that a specific AGO other than AGO1 is developed for the antiviral ...other ...
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RNA-Based Immunity Terminates Viral Infection in Adult Drosophila in the Absence of Viral Suppression of RNA Interference: Characterization of Viral Small Interfering RNA Populations in Wild-Type and Mutant Flies
... viral RNA genomes in fruit flies and mosquitoes induces the production of virus-derived small interfering RNAs (siRNAs) to specifically reduce virus accumulation by RNA interference ...
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Prediction for Target Sites of Small Interfering RNA Duplexes in SARS Coronavirus
... alone[4]. The RNAi triggered by dsRNA is a phenomenon of homology-dependent gene silencing[5][6][7]. It was found that the small interfering RNA (siRNA, 21-25 nt long) plays an important role in ...
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Targeted, systemic non viral delivery of small interfering RNA in vivo
... of RNA interference (RNAi) in mammalian cells, making in vivo therapeutic applications of RNAi increasingly likely to emerge ...delivered small interfering RNA (siRNA) duplexes and ...
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Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy
... and small molecule inhibitors, have been used at the bedside, leading to important ...that small interfering RNA (siRNA) is able to regulate the expression of genes, by a phenomenon known as ...
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Inhibitory effect of small interfering RNA on dengue virus replication in mosquito cells
... Because the short siRNAs are unstable inside the cells, and also diluted by continuous cell division, the siRNA contents in the cells decline over time resulting in the weakening of interference effect. From the ...
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Role of the Trypanosoma brucei HEN1 Family Methyltransferase in Small Interfering RNA Modification
... of RNA interference (RNAi) has been investigated in Trypanosoma brucei and to a lesser degree in Leishmania (Viannia) ...double-stranded RNA (dsRNA) and in ...brucei small interfering ...
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Inhibition of foot and mouth disease virus replication in vitro and in vivo by small interfering RNA
... FMD. RNA interference (RNAi) is a process of sequence-specific, posttranscriptional gene silencing (PTGS) in animals and plants, which can be induced by 21- to 23-nucleotide (nt) siRNA that demonstrates ...
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Stable expression of small interfering RNA sensitizes TEL PDGFβR to inhibition with imatinib or rapamycin
... USA. Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL– TEL-PDGFβR–mediated human leukemias, but resistance may ...using RNA interference ...
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Effective small interfering RNA delivery in vitro via a new stearylated cationic peptide
... Keywords: RNA interference, cellular uptake, cytotoxicity, gene silencing, physicochemical characterization Introduction RNA interference is a specific cellular post-transcriptional gene ...
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Small-Interfering RNA-Eluting Surfaces as a Novel Concept for Intravascular Local Gene Silencing
... New drug-eluting stent (DES) methods have recently been demonstrated to improve outcomes of intravascular interventions. A novel technique is the design of gene-silencing stents that elute specific ...
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Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma
... in RNA interference, it is expected that DCs can be good targets because of their location and their prominent particle uptake ability, including the uptake of short-based ...
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Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA
... RNA interference (RNAi) has been successfully applied in suppression of hepatic cancer ...dual small interfering RNA (siRNA) expression system, which could simultaneously express two ...
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Small interfering RNA targeting S100A4 sensitizes non-small-cell lung cancer cells (A549) to radiation treatment
... RNA interference (RNAi) reduced mRNA and pro- tein levels of specific genes through posttranscriptional gene silencing mechanisms. This technology is highly efficient, specific, and minimally toxic. This ...
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Caenorhabditis elegans RIG I Homolog Mediates Antiviral RNA Interference Downstream of Dicer Dependent Biogenesis of Viral Small Interfering RNAs
... of small RNAs revealed an abundant population of Dicer-dependent virus-derived small interfering RNAs (vsiRNAs) in drh-1 single and double mutant ani- mals after infection with Orsay virus, a ...
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Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs.
... of small RNAs revealed an abundant population of Dicer-dependent virus-derived small interfering RNAs (vsiRNAs) in drh-1 single and double mutant ani- mals after infection with Orsay virus, a ...
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Antiviral RNA Interference Responses Induced by Semliki Forest Virus Infection of Mosquito Cells: Characterization, Origin, and Frequency-Dependent Functions of Virus-Derived Small Interfering RNAs
... RNA interference (RNAi) is an important mosquito defense mechanism against arbovirus ...virus-derived small interfering RNAs (viRNAs) from viral double-stranded RNA (dsRNA) is a key ...
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