Small multidrug resistance protein
How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps
... ultidrug resistance (MDR) efflux pumps are found in all bacterial ...are protein complexes capable of transporting substrate molecules with various sizes and proper- ties from the inside of the bacterial ...
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Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals
... the resistance plasmid is balanced by the selective effect of the added drug (1, ...the small differences in fitness observed between the fluorescent markers (see Table S1 in the supplemental ...regulatory ...
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Decreased functional activity of multidrug resistance protein in primary colorectal cancer
... into small pieces, washed in HBSS buffer (14025-092, GIBCO Invitrogen, Csertex, Budapest, Hungary) then incubated in 1 ml of 4 mg/ml collagenase (LS004212, Worthington collagenase type IV, Worthington Biochemical ...
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Expression of multidrug resistance proteins is localized principally to the Malpighian tubules in larvae of the cabbage looper moth, Trichoplusia ni
... in resistance of tissues and organisms to drugs and xenobiotics (Cole et ...ABC protein subfamilies that can confer drug resistance is the multidrug resistance proteins (MRPs), which ...
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TgPRELID, a Mitochondrial Protein Linked to Multidrug Resistance in the Parasite Toxoplasma gondii
... TGGT1_254250 protein is annotated at ToxoDB ...F0002 resistance were found in a small region of the predicted PRELI domain ...entire protein using other domain-finding software programs, ...
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Multidrug Resistance in Fungi
... drug resistance (reviewed in references 79 and ...in multidrug resistance has been ob- scured by their better-publicized ...MFS protein Flr1p contributes to resistance to the antifungal ...
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Lapatinib Antagonizes Multidrug Resistance-Associated Protein 1-Mediated Multidrug Resistance by Inhibiting Its Transport Function
... Some small molecule inhibitors competing with ATP-binding at the tyro- sine kinase domain have emerged from oncology clinical trials into mainstream cancer ...
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Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High Diversity Transposon Libraries
... a small molecule or other metab- olites produced as a result of cell envelope ...this protein plays a role, directly or indirectly, in regulating cell membrane potential or cell envelope positive ...
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Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU.
... a small protein, belonging to the HSP family in human cells, and a relatively newly identified regulator of 5-FU resistance in colorectal cancer (Schweiger et ...the resistance to chemotherapy ...
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ATP-binding cassette (ABC) transporters in normal and pathological lung
... the multidrug resistance-associ- ated protein 1 (MRP1) were initially detected in tumour cell ...so-called multidrug resistance ...of small cell lung cancer (SCLC) and ...
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The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer
... There was a clear background without nonspecific stain- ing in negative control slides (Fig 1A). The three proteins were stained brownish granules, with P-gp mainly located on the membrane and cytoplasm (Fig 1B), LRP on ...
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Original Article Reversing the ABCG2-mediated multidrug resistance by AG1478 and small interfering RNA in laryngeal squamous cell carcinoma
... Exponentially growing cells were washed with ice-cold PBS for 2 times, and lysed in RIPA buf- fer with protease inhibitor PMSF for 30 minutes with occasional rocking followed by centrifuga- tion at 12,000 g at 4°C for 15 ...
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... androgen-induced protein; P-gp=P-glycoprotein; KO= knockout; WT=wild-type; BCRP=breast cancer resistance protein; MRP1=multidrug resistance-associated protein ...
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Molecular Modelling of Human Multidrug Resistance Protein 5 (ABCC5)
... No X-ray crystal structure of ABCC5 has been reported, but molecular models of ABCC5 may be constructed by homology using a known 3D crystal structure of an evolutionary related protein as a template. Different ...
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Phage Resistance in Multidrug Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption
... phage resistance patterns were not materially affected by bacterial cultivation in broth versus bacterial cultivation on ...different resistance patterns and time to resistant outgrowth between ...
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ANTIBIOTIC RESISTANCE: OVERVIEW AND MECHANISMS
... adapter protein joining the two membrane ...drug resistance and shows the broadest substrate ranges that include most conventional classes of ...OM protein acts as barriers against the movement of ...
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Clinical Insights from Metagenomic Analysis of Sputum Samples from Patients with Cystic Fibrosis
... antibiotic resistance in this microbial community were multidrug resistance FIG 4 An overview of clinical and metagenomic data for patient ...
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Lipid bilayer composition influences small multidrug transporters
... a protein sample that had already been quantified on another gel, to enable normalising between ...gels). Protein-containing vesicle samples were run on 10% SDS denaturing gels and transferred to polyvinyl ...
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Multi drug resistance and extended spectrum beta lactamase producing Gram negative bacteria from chicken meat in Bharatpur Metropolitan, Nepal
... The prevalence of Salmonella spp. was 26.2% which is similar to the studies carried out in USA and South Korea [13, 19]. In contrast, higher prevalence rate of Salmo- nella spp. was found in Southern Thailand (67.5%) ...
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Yeast ABC proteins involved in multidrug resistance
... The transporters belonging to the PDR (ABCG) subfamily of yeast ABC proteins are often associated with the extrusion of various growth inhibitors, but not all of them are multidrug efflux pumps. The best ...
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