Small Vessel Disease (SVD)
Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease
... AUC 5 area under the receiver operating characteristic curve; CMB 5 cerebral microbleeds; DSM-5 5 Diagnostic and Statistical Manual of Mental Disorders, 5th edition; DTI 5 diffusion tensor imaging; EF 5 executive ...
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Neuroimaging in Cerebral Small Vessel Disease
... cerebral small vessel disease (SVD) is difficult because there is no consensus on clinical criteria and therefore, imaging is important for ...In SVD multiple punctuate or confluent ...
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Longitudinal decline in structural networks predicts dementia in cerebral small vessel disease
... Cerebral small vessel disease (SVD) is the most common pa- thology underlying vascular ...by SVD, such as executive function and processing ...conventional SVD brain pathologies ...
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Accelerated development of cerebral small vessel disease in young stroke patients
... ratio; SVD 5 small vessel disease; SWI 5 susceptibility-weighted imaging; TE 5 echo time; TI 5 inversion time; TOAST 5 Trial of Org 10172 in Acute Stroke Treatment; TR 5 repetition time; WMH 5 ...
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Mutation of FOXC1 and PITX2 induces cerebral small vessel disease
... cerebral small-vessel disease (CSVD) exhibit perturbed end-artery function and have an increased risk for stroke and age-related cognitive ...
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<p>Small vessel disease to subcortical dementia: a dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit</p>
... resistance. These changes induce a progressive decrease in CBF which is thought to be one of the key element for the progression from small vessel disease towards subcortical vascular dementia. 277 ...
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Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease
... In the article “Clinical phenotype, atrophy, and small vessel disease in APOEe2 carriers with Alzheimer disease” by Groot et al., 1 published online ahead of print on October 19, 2018, there ...
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Using DTI to assess white matter microstructure in Cerebral Small Vessel Disease (SVD) in multi-centre studies.
... Diffusion tensor imaging (DTI) metrics such as Fractional Anisotropy (FA) and Mean Diffusivity (MD) have been proposed as clinical trial markers of cerebral small vessel disease due to their ...
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Cerebral small vessel disease and Alzheimer’s disease
... Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and ...
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Original Article The association between hyperhomocysteinemia and cerebral small vessel disease
... Cerebral small vessel disease (CSVD) is a syn- drome of clinical, pathological and neuroimag- ing manifestations, such as white matter hyper- intensity and lacunar infarction, caused by intracranial ...
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Baykara, Ebru (2018): Imaging markers of cerebral small vessel disease. Dissertation, LMU München: Graduate School of Systemic Neurosciences (GSN)
... Alzheimer's disease and it is a major health concern for the aging ...cases, small vessel disease is the underlying cerebral pathology (Pantoni, ...Cerebral small vessel ...
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Total small vessel disease score and risk of recurrent strokeValidation in 2 large cohorts
... total SVD score had very similar prognostic value in predicting risk of recurrent stroke (c statis- tic ...total SVD score had similar prognostic value in predic- tion of recurrent stroke with no ...
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Depression in small-vessel disease relates to white matter ultrastructural damage, not disability
... than SVD: any cortical infarction, subcortical infarcts ...with SVD, assessments were performed ...Two SVD cohorts (discovery and replication) were ...with SVD met the Geriatric Depression ...
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Structural network efficiency is associated with cognitive impairment in small-vessel disease
... NBS analysis identified a single subnetwork (p , 0.001) with maximally impaired connectivity in SVD. This network is widely distributed (figure 1), involving 29 edges between 27 unique nodes (tables e-2, e-3, and ...
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Update on cerebral small vessel disease: a dynamic whole-brain disease
... of disease and irreversible once demyelination or axonal damage has happened; some perhaps less white lesions might be reversible if they are mainly interstitial fl uid (ISF) imbalances before perman- ent tissue ...
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Quantitative functional magnetic resonance imaging in cerebral small vessel disease
... a small study of 12 patients with a radiologically-confirmed lacunar stroke found that VMR was significantly increased after treatment with Perindopril for two weeks (75), which might suggest a potential benefit ...
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How common are single gene mutations as a cause for lacunar stroke?A targeted gene panel study
... Cerebral small vessel disease (SVD) accounts for around 25% of strokes in the form of lacunar strokes and deep intracerebral hemorrhages (ICH), 1 and is the primary pa- thology underlying ...
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Integrated Structural And Functional Biomarkers For Neurodegeneration
... Alzheimer's Disease pathology in the earliest stages of ...of small vessel disease, are more highly associated with Alzheimer's Disease pathology than current mainstream imaging ...
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Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226)
... on vessel development and repressive effect on expression of some matrix metal- ...ameliorates disease manifestations in CADASIL mice, 40 highlighting shared pathologic processes in sporadic and monogenic ...
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Recent progress in translational research on neurovascular and neurodegenerative disorders
... of small- vessel disease that is characterized by occlusions resulting from endovascular injection of fluorescent microspheres that target ∼12 m diameter penetrat- ing arterioles, which can be ...
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