Sodium channels
Differential lipid dependence of the function of bacterial sodium channels
... voltage-gated sodium channels, we compared the activity of three bacterial sodium channel homologues (NaChBac, NavMs, and NavSp) by cumulative 22 Na + uptake into proteoliposomes containing a 3:1 ...
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Sodium channels and mammalian sensory mechanotransduction
... Voltage-gated sodium channels underpin the propaga- tion of action potentials. However, whether they also contribute to mechanotransduction is not known. A number of Nav1.7 mutations result in various pain ...
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Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels
... human channels, notably at the beginning of the transmem- brane S3 helix in all domains of all nine human iso- ...human sodium channels, they are all associated with disease states: W190R in DI and ...
11
Difference of Sodium Currents between Pediatric and Adult Human Atrial Myocytes: Evidence for Developmental Changes of Sodium Channels
... potassium channels currents in animal hearts [13-15, ...[16]. Sodium channel encoding genes including ...in sodium channel subunits may contribute to changes in macroscopic sodium currents ...
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Pharmacological targeting of long QT mutant sodium channels
... of sodium channels by mexiletine was estimated in two dif- ferent ...First, sodium current was measured at 2 20 mV after holding the cell membrane potential at 2 120 mV for 5 s to remove in- ...and ...
8
Inherited disorders of voltage gated sodium channels
... The sodium channelopathies were among the first recognized ion channel diseases and continue to attract widespread clinical and scientific ...gated sodium channels and provided new insights into the ...
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Dual roles of voltage gated sodium channels in development and cancer
... Dual roles of voltage gated sodium channels in development and cancer FAHEEMMUDDEEN PATEL and WILLIAM J BRACKENBURY* Department of Biology, University of York, Heslington, York, UK ABSTRACT Voltage ga[.] ...
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PHARMACOLOGICAL CHARACTERIZATION OF Bunodosoma TOXINS ON MAMMALIAN VOLTAGE DEPENDENT SODIUM CHANNELS
... gated sodium channels in different excitable ...different sodium channels (from ...cloned sodium channels expressed in Xenopus laevis oocytes 9 ...
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Role of the C terminal domain in the structure and function of tetrameric sodium channels
... Voltage-gated sodium channels have essential roles in electrical ...Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a ...
11
Sodium channels in cardiac myocytes
... individual channels switching between two modes of gating (fast gating or slow ...of sodium channels could be responsible for slowly inactiviting sodium currents (Moorman et ...chattering ...
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The emerging role of voltage gated sodium channels in tumor biology
... Voltage-gated sodium channels (VGSCs) are transmembrane proteins which function as gates that control the flux of ions across the cell ...ion channels for action potentials in excitable tissues and ...
8
CPT-cGMP Is A New Ligand of Epithelial Sodium Channels
... Epithelial sodium channels (ENaC) are localized at the apical membrane of the epithelium, and are responsible for salt and fluid ...impaired sodium excretion and subsequent hypertension as well as ...
8
Pharmacological properties of axonal sodium channels in the cockroach Periplaneta americana L I Selective block by synthetic saxitoxin
... From the concentration dependence of sodium, current suppression it is concluded that individual sodium channels are blocked by single molecules of synthetic saxitoxin which bind reversi[r] ...
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Covalent linkage of bacterial voltage gated sodium channels
... 7 Shaya, D. et al. Voltage-gated sodium channel (Na-V) protein dissection creates a set of functional pore-only proteins. Proceedings of the National Academy of Sciences of the United States of America 2011; 10; ...
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Voltage-gated sodium channels dysfunction in depression: the hypothesis
... Voltage-gated sodium (Na+) channels (VGSCs) are responsible for action potential initiation and propagation in most electrically excitable cells which are implicated in a wide range physiological functions ...
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Voltage-gated sodium channels as targets for pyrethroid insecticides
... group of compounds that have been used extensively for the control of arthropod pests of agricultural crops and vectors of animal and human disease. Unfortunately, this has led to the development of resistance to the ...
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Voltage gated sodium channels as targets for pyrethroid insecticides
... in sodium channel sequences which make pyrethroids less able to bind to mammalian ...the channels makes a difference to sensitivity, and that gene sequences reveal that arthropods generally have a ...
6
Dual roles of voltage-gated sodium channels in development and cancer
... human sodium channel beta1B subunit, a novel splicing variant of the beta1 ...of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 ...
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Molecular and functional characterization of voltage-gated sodium channels in human sperm
... Results: The mRNAs that encode the different Nav alpha subunits (Nav1.1-1.9) were all expressed in capacitated human spermatozoa. The mRNAs of the auxiliary subunits beta1, beta3 and beta4 were also present. ...
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Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells
... phases [43]; it was suggested that cell division is depressed when ASIC1 and ENaC are inhibited and that phosphorylation of ERK1/2 may be an underlying mechanism [43]. This group also found that interactions between ...
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