Sodium-iodide symporter
HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells
... Active iodide accumulation marks an initial step in the bio- synthesis of iodine-containing thyroid hormones in thyroid follicular cell ...membrane, sodium/iodide symporter (NIS) might ...
15
Original Article Radionuclide imaging and therapy in malignant melanoma after survivin promoter-directed sodium iodide symporter gene transfer in vitro and in vivo
... the sodium iodide symporter gene under control of the survivin promoter ...higher iodide uptake in all 50, 100, or 150 MOIs examined cells ...
6
The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis
... human sodium iodide symporter (hNIS) gene has emerged as one of the most prom- ising reporter genes in preclinical and translational research for oncology and gene therapy (8, ...
11
Original Article Improved radioiodine-131 imaging of prostatic carcinoma using the sodium iodide symporter gene under control of the survivin promoter
... [6] Schmohl KA, Gupta A, Grünwald GK, Trajkovic- Arsic M, Klutz K, Braren R, Schwaiger M, Nel- son PJ, Ogris M, Wagner E, Siveke JT, Spitzweg C. Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the ...
6
Original Article Targeting of pertechnetate imaging of HepG2 hepatocellular carcinoma through the transduction of the survivin promoter controls the sodium iodide symporter
... [22] Gao XF, Zhou T, Chen GH, Xu CL, Ding YL, Sun YH. Radioiodine therapy for castration-resis- tant prostate cancer following prostate-specific membrane antigen promoter-mediated trans- fer of the human sodium ...
7
Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells
... of sodium-iodide symporter (NIS or SLC5A5) protein, which can serve the purpose of the targeted radioiodine ...of iodide ions inside the ...
15
Tracking dendritic cell migration into lymph nodes by using a novel PET probe 18F-tetrafluoroborate for sodium/iodide symporter
... Human sodium/iodide symporter; KClO4: Potassium perchlorate; MHC: Major histocompatibility complex; PE: Phycoerythrin; PET: Positron emission tomography; ROI: Region of interest; SPECT: Single- ...
9
[18F]Tetrafluoroborate ([18F]TFB) and its analogs for PET imaging of the sodium/iodide symporter
... Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of ...and iodide analogs has gained much interest in recent years ...
14
Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus
... We would like to acknowledge Meryl Greenblatt for her excellent editing skills with this paper. Special thanks to the Fagin lab at MSKCC for kindly providing the PCCL3 cell line used for radiouptake assays and Valerie ...
14
Hypoxia-targeted 131 I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery
... the sodium iodide symporter (NIS) [12–14] as therapy genes, we demonstrated the active homing of MSCs to the tumor stroma resulting in a significant reduction in tumor growth and prolonged animal ...
16
Codon-optimized Human Sodium Iodide Symporter (opt-hNIS) as a Sensitive Reporter and Efficient Therapeutic Gene
... To generate a more efficient in vivo reporter and therapeutic gene, we optimized the coding se- quence of the human sodium/iodide symporter (NIS) gene by replacing NIS DNA codons from wild type to ...
11
Sodium Iodide Symporter for Nuclear Molecular Imaging and Gene Therapy: From Bedside to Bench and Back
... agnostic and therapeutic purposes with successful outcomes. However, the uptake mechanism of radio- iodine into thyroid tissue or thyroid cancers was not fully elucidated until 1996, when the sodium iodide ...
11
Overcoming the lack of expression of the sodium iodide symporter protein in anaplastic thyroid cancer stem cells by targeting the phosphatidyl inositol 3 kinase signaling pathway
... est sodium-iodide symporter (NIS) ...for iodide accumulation in ...two sodium molecules along with one iodide molecule from the bloodstream into these cells to facilitate thyroid ...
6
A novel oncolytic viral therapy and imaging technique for gastric cancer using a genetically engineered vaccinia virus carrying the human sodium iodide symporter
... GLV-1 h153 is a replication-competent, recombinant vac- cinia virus derived from its parental strain, GLV-1 h68, via homologous recombination. It contains four inserted cas- settes encoding Renilla Aequorea luciferase- ...
7
[18F]tetrafluoroborate as a PET tracer for the sodium/iodide symporter: the importance of specific activity
... human sodium/iodide symporter (hNIS) [5], it has been widely used in reporter gene imaging to study in vivo trafficking of metastatic cancer cells [6], stem cells [7] and immune cells ...to ...
10
Original Article Sodium iodide symporter expression driven by the survivin promoter enables radionuclide imaging and therapy for A549 non-small cell lung cancer
... Abstract: This study aimed to develop a gene expression targeting method specific for the imaging and therapy of non-small cell lung cancer A549 cells using an adenovirus vector containing the human sodium ...
11
Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells
... a sodium/iodine symporter (NIS), and subsequent radioiodide-refractory (RAI) metastatic ...and Iodide uptake by inhibition of mitogen-activated protein kinase (MAPK) ...
6
Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer.
... tumour iodide uptake was measured by excision of the whole tumour and other tissues, and detection of gamma emissions using a Wallac 1470 Wizard automatic gamma counter (Perkin Elmer, ...
39
Congenital hypothyroidism due to mutations in the sodium/iodide symporter Identification of a nonsense mutation producing a downstream cryptic 3' splice site
... from the hydropathic and secondary structure of the protein (12). Compared to the 12-segment model for the transmem- brane domain of other sodium-dependent cotransporters (23), it lies close to one of the two ...
9
Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice
... accumulate iodide through NIS ...the iodide, role of NIS protein in extrathyroidal tissues may be to pool or to transfer the ...than iodide. Due to the similarity in size and charge to iodide, ...
6