Soft tissue sarcomas
Olaratumab in soft-tissue sarcomas.
... tumour soft-tissue ...in soft-tissue sarcomas is challenging: there are more than 70 different histological subtypes, with heterogeneous genetic make-up and clinical behaviour including ...
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MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas
... Liposarcomas are rare connective tissue cancers, account for about 18% of all soft tissue sarcomas. Of the four types of liposarcomas, well and dedifferentiated liposarcoma represent the most ...
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Utility of Multi-Parametric Quantitative Magnetic Resonance Imaging for Characterization and Radiotherapy Response Assessment in Soft-Tissue Sarcomas and Correlation With Histopathology.
... Soft-tissue sarcomas are often highly heterogeneous tumors with variable components that can include cellular tumor, fat, necrosis, and cystic ...many soft-tissue sarcoma sub-types, ...
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Controversies and consensus of neoadjuvant chemotherapy in soft-tissue sarcomas
... of soft-tissue sarcomas and is the mainstay of treatment in patients with advanced or metastatic ...in soft-tissue sarcomas is less well ...localised soft-tissue ...
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Trabectedin for advanced soft tissue sarcomas: optimizing use
... are classified into five different types: well-differentiated, myxoid, round cell, pleomorphic, and de-differentiated. Myxoid liposarcomas account for 40% of liposarcomas and almost 10% of all adult ...
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The challenge of finding new therapeutic avenues in soft tissue sarcomas
... for sarcomas in the last few years? Since the early 1970’s sys- temic therapies for locally advanced and metastatic soft tissue sarcomas have been restricted to very few effec- tive and ...
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Update on the role of trabectedin in the treatment of intractable soft tissue sarcomas
... Abstract: Soft tissue sarcomas (STS) represent a variety of tumors of mesenchymal origin, accounting for about 1% of all adult cancers. This group of tumors comprises over 60 different histotypes ...
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Targeted therapy for soft tissue sarcomas in adolescents and young adults
... alveolar soft part sarcoma; AYAs, adolescent and young adults; CAR, chimeric antigen receptor; COG, Children’s Oncology Group; CR, complete remission; DSRCT, desmoplastic small round cell tumor; EGFR, endothelial ...
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Pazopanib in the management of advanced soft tissue sarcomas
... The answer could be biological in nature, with pazopanib having some inhibitory property that other agents lack. Alternatively, pazopanib may have pharmacodynamic or pharmacokinetic properties that favor its activity. ...
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High EZH2 expression is correlated to metastatic disease in pediatric soft tissue sarcomas
... proliferation and inhibiting myogenic differentiation of paediatric soft tissue sarcomas. More importantly, our results indicate that pharmacological targeting of EZH2 might represent a potentially ...
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Correlation of Oncologic Long-Term Results and Genetic Instability in Soft Tissue Sarcomas
... Purpose: Soft tissue sarcomas (STS) represent a heterotop group of ...high-grade sarcomas, the 5-year and 10-year survival probabilities were significantly lower in LOH-positive tumours ...in ...
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Soft tissue sarcomas in adolescents and young adults: a comparison with their paediatric and adult counterparts.
... on soft tissue sarcomas of adolescence and young adulthood, and exemplify the different features of the most prevalent soft tissue sarcomas that are either typical paediatric ...
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Preserving quality of life as a key treatment goal in advanced soft tissue sarcomas.
... with soft tissue sarcomas (STS) and extremity bone sarcomas, the Toronto Extremity Salvage Score (TESS) is a disease-specific PRO to evaluate physical function ...
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A review of soft-tissue sarcomas: translation of biological advances into treatment measures
... Abstract: Soft-tissue sarcomas are rare malignant tumors arising from connective tissues and have an overall incidence of about five per 100,000 per ...specific sarcomas, very few are ...
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Cytoplasmic maspin expression predicts poor prognosis of patients with soft tissue sarcomas
... Soft tissue sarcomas (STS) are relatively rare malignant mesenchymal tumors and constitute less than ...of sarcomas, histological typing does not provide sufficient informa- tion for ...
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Aldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas
... Abstract: Despite available therapies after initial systemic therapy, prognosis remains poor in relapsed or refractory soft tissue sarcomas (STS). The rational and clinical development of novel ...
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Preoperative radiotherapy of soft-tissue sarcomas: surgical and radiologic parameters associated with local control and survival
... We recognize the retrospective nature of this study as its main limitation. However, since our aim was not a comparison of preoperative with postoperative radio- therapy, a question which has been addressed in other ...
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Development of Multi-disciplinary Approach for Bone and Soft-tissue Sarcomas in Japan
... and soft- tissue sarcomas are basically consisted of tumor wide resection and a variety of reconstructive ...and soft-tissue tumors including sarcomas was vaguely termed ...
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Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304
... Background: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. ...
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Feasibility of chemosensitivity testing in soft tissue sarcomas
... of sarcomas, either as single agents or as part of drug com- ...in soft tissue sarcomas due to the lack of a prospected ...adult soft tissue sarcoma ...
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