soluble CD40 ligand
A Study of Serum Soluble Cd40 Ligand Level in Patients with Acute Coronary Syndrome.
... Dr.M.Manonmani post graduate student in the department of Biochemistry, Thanjavur Medical College, Thanjavur is doing A Study of Serum Soluble CD40 Ligand Level in Patients With Acute Coronary ...
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Soluble CD40 ligand and prolactin levels in migraine patients during interictal period
... Abstract The relationship of migraine with cardiovas- cular diseases has been clarified by many studies, and currently, migraine is suggested to be a systematic vascu- lopathy. Inflammation, thrombosis and impaired ...
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Soluble CD40 ligand and Oxidative Response are Reciprocally Stimulated during Shiga Toxin-associated Hemolytic Uremic Syndrome.
... release soluble CD40 ligand (sCD40L) which in turn contributes to oxidative imbalance, triggering the release of reactive oxidative species (ROS) on various cellular ...
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Internalization of IgG-Coated Targets Results in Activation and Secretion of Soluble CD40 Ligand and RANTES by Human Platelets
... Platelets are crucial elements for maintenance of hemostasis. Other functions attributable to platelets are now being appreciated, such as their role in inflammatory reactions and host defense. Platelets have been ...
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Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?
... and CD40- or CD40L-deficient mouse models of mesenteric ischemia/ reperfusion injury and observed lung damage only when platelets, CD40, or CD40L were present, whereas platelet- depleted mice and those ...
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High levels of soluble CD40 ligand and matrix metalloproteinase 9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis
... on CD40-CD40L interaction [11,38]. Moreover, CD40-CD40L simultaneously with TNF-α is a potent inducer of nitric oxide production, which plays a main role in antimicrobial ...
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Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis
... The role of sCD40L in sepsis remains unclear; but it is possible that there are similarities with findings observed in coronary artery disease [2]. CD40L is stored in a - granules in unstimulated platelets but rapidly ...
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The soluble CD40 ligand sCD154 in systemic lupus erythematosus
... Immunoprecipitation and immunoblotting of soluble CD154. Human plasma (500 µL) from SLE patients or healthy donors were centrifuged at 10,000 g before immunoprecipitation. After preclearing with normal mouse IgG1 ...
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Soluble CD40 ligand activated human peripheral B cells as surrogated antigen presenting cells: A preliminary approach for anti HBV immunotherapy
... In this study, we used recombinant human GMP-qual- ity trimeric soluble CD40L to activate PBMC-derived B cells. We established and optimized the culture system for CD40L-B cells, which allows B cell activation and ...
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Potential predictive role of chemotherapy-induced changes of soluble CD40 ligand in untreated advanced pancreatic ductal adenocarcinoma
... biomarkers. CD40 is a member of the tumor necrosis factor superfamily. CD40–sCD40L interaction is considered to contribute to the promotion of tumor cell growth and ...
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Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma
... CD40 ligand (CD40L) was initially identified as a T-cell receptor for ligation of the co-stimulatory molecule CD40, and CD40-CD40L interaction was considered as a key event for effective ...
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<p>Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?</p>
... special parameter estimation. Serum samples were left for clotting, and then were centrifuged at 3,000 rpm for 20 minutes. Serum was separated and divided into three portions: one for routine parameter estimation (random ...
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Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro
... CD40 ligand (CD40L) and GITR ligand (glucocorticoid-induced tumor necrosis factor receptor-related protein ligand [GITRL]) are tumor necrosis factor superfamily molecules that can be used as ...
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Multimeric Soluble CD40 Ligand and GITR Ligand as Adjuvants for Human Immunodeficiency Virus DNA Vaccines
... of soluble CD40L trimer (sCD40LT) (63) was previously reported to be an effective adjuvant for a DNA vaccine encoding a nonsecreted antigen (  -galactosidase) ...
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Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study
... [15]. Soluble CD40 ligand (sCD40L), a member of the TNF family produced by activated platelets, upregulates the expression of inflammatory adhesion receptors and cellular activators, and circulates ...
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Diminished expression of CD40 ligand by activated neonatal T cells
... of CD40 ligand by activated neonatal T cells and the response of neonatal B cells when activated through ...of CD40 ligand peaked simultaneously in both activated adult and neonatal cells, ...
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Effect of cilostazol on arterial stiffness and vascular adhesion molecules in type 2 diabetic patients with metabolic syndrome: a randomised, double-blind, placebo-controlled, crossover trial
... Several limitations of our study must be acknow- ledged. First, this study was confined to type 2 diabetic patients with metabolic syndrome, and results from this study should not be extrapolated to other patient popu- ...
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Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
... cell CD40 ligation, along with de- lineation of the immunologic consequences of the hyperIgM syndrome, attributable to a variety of mutations in the X chro- mosome-encoded gene for CD40L (22–28), have defined the ...
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CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally replicating adenovirus
... increased ligand expression compared to the replication- deficient counterpart and this translated into signifi- cantly greater induction of cell death in a CD40-depen- dent ...
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Cloning, sequence analysis and expression of ovine CD154 (CD40 ligand)
... amino acid sequence of oCD154 showed a high degree of homology to respective CD154 from cattle (97%), pig (91%) though relatively lower homology to human (87%), cat (86%), dog (83%) and mouse (77%). Therefore, these ...
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