Soluble cd40l
Original Article Association of plasma soluble CD40L and P-selectin with large-artery atherosclerosis stroke
... Abstract: Objective: To investigate the association of plasma soluble CD40L (sCD40L) and soluble P-selectin (sP- selectin) with large-artery atherosclerosis (LAA) stroke. Methods: We recruited 120 ...
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Mechanisms of C reactive protein, interleukin 6 and soluble CD40L blood concentration changes after coronary stent implantation
... Soluble CD40L release from the platelet surface is the sole mechanism for the down-regulation of ...membrane CD40L from platelets is fully released as sCD40L and it has a half-life of approximately ...
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In Vitro Effect of Soy Isoflavone and Equol on Soluble CD40L Release Stimulated by Ristocetin in Platelets from Postmenopause Women
... The measurement of sCD40L was performed as described by Enomoto et al. [8]. In brief, PRP (3.0 × 10 8 cells/ml) were preincubated with different concentration of genistein, daidzein, equol or a solvent control (0.5% ...
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Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behçet’s disease
... evaluated soluble mediators were in- creased in plasma from patients with BD in comparison to that from HCs; however, the elevation in sCD40L plasma levels in patients with BD was ...
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Multimeric Soluble CD40 Ligand and GITR Ligand as Adjuvants for Human Immunodeficiency Virus DNA Vaccines
... molecule. Soluble trimeric forms of CD40L have been produced, but in vitro data indicate that multimeric, many-trimer forms of soluble CD40L are more ...4-trimer soluble forms of ...
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Ultrafine particles and platelet activation in patients with coronary heart disease – results from a prospective panel study
... and soluble CD40L (sCD40L). CD40L, a glycoprotein released from activated platelets [13], promotes the process of thrombus formation in vivo ...released CD40L is proinflammatory, pro- ...
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Do CD40L and CD40 contribute to sickle cell anemia?
... and CD40L are also elevated in SCA (9-13). Studies have also shown that CD40L is also elevated in the plasma of individuals suffering from systemic lupus erythematosus, rheumatoid arthritis and sickle cell ...
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Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study
... plasma soluble CD40L, and platelet-leukocytes aggregates were assayed by flow cytometry at admission and 48 h later, and then at the time of sepsis diagnosis (Sepsis-3 criteria) and 7 days later for sepsis ...
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Expression of CD40 Ligand on CD4+ T-Cells and Platelets Correlated to the Coronary Artery Lesion and Disease Progress in Kawasaki Disease
... of CD40L were enhanced in angina patients, suggesting that CD40L–CD40 inter- action may play a pathogenic role in both the trig- gering and the propagation of acute coronary syn- ...together, ...
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CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation
... membrane-bound CD40L (mCD40L) on its immune-stimulatory function are ...versus soluble CD40L (sCD40L) on T24 bladder carcinoma gene expression ...
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Hyper IgM syndrome type 4 with a B lymphocyte–intrinsic selective deficiency in Ig class switch recombination
... We are grateful to Immunex (Seattle, Washington, USA) for kindly providing the recombinant soluble CD40L. We thank I. Tezcan and F. Ersoy (Ankara, Turkey) for taking care of patients. This work was ...
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Chronic inflammation in sickle cell disease: potential role of platelets and the inflammatory mediator CD40L
... 14 CD40L is now known to be expressed on a variety of cell types, including ...activation, CD40L is exposed to the platelet surface, 15 then cleaved to generate a soluble product 16 that retains the ...
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X-linked Hyper IgM (HIGM1) in an African kindred: the first report from South Africa
... detect CD40L expression on his activated T-cells. A deficiency of CD40L was also confirmed in the youngest male at the age of 5 ...the CD40L mRNA of the affected ...
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Phytochemical Investigation and Standardization of Mahogany Tea Powder from Swietenia mahagoni Leaves
... Ash values: A high ash value is indicative of contamination, substitution, adulteration, or carelessness in preparing the drug or drug combinations for marketing. The powder was found to have total ash values of 3.32% ...
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Physicochemical and phytochemical constitutions of rachis of acrostichum aureum l.
... About 5g of air-dried rachis powder was taken in a stoppered flask. 100ml of the respective solvent were added, shaken well and allowed to stand for 24h with occasional shaking. Then the content was filtered. 50ml of the ...
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Multiple effects of CD40–CD40L axis in immunity against infection and cancer
... CD40– CD40L signaling in B cells is important for generation of long-lived plasma cells and memory B cells as well as for their ...The CD40L is a natural ligand for CD40 and a Type II, 39-kDa membrane ...
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Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria.
... 1994. Soluble intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1) and tumor necrosis factor receptor (55kDa TNF-R) in patients with acute Plasmodium falciparum ...
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Cell adhesion factors in cnidarians
... Appendix B Sub Family C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Solu[r] ...
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CDP7657, an anti CD40L antibody lacking an Fc domain, inhibits CD40L dependent immune responses without thrombotic complications: an in vivo study
... was evaluated in clinical trials for a range of auto- immune diseases. Results from a phase 2 study in pa- tients with systemic lupus erythematosus (SLE) were encouraging, with significant reductions in disease bio- ...
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In vivo regulation of autoreactive B cells by IL-6, CD40L and TNF[alpha]
... IL-6, CD40L and TNFα secreted by TLR-stimulated DCs and MΦs act on autoreactive B cells to repress Ig secretion [1-3] (Chapter ...IL-6, CD40L and TNFα regulate autoreactive B cells (Chapter ...IL-6, ...
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