soluble epoxide hydrolase
Original Article Soluble epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid, represses human aortic smooth muscle cell proliferation and migration by regulating cell death pathways via the mTOR signaling
... 15], which conversion is the consequence of soluble epoxide hydrolase (sEH) activity [16]. Numerous studies have evoked that inhibition of sEH, with an ensuing decrease in EET degra- dation, may ...
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Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity
... Soluble epoxide hydrolase (sEH) has recently gained increasing attention because the inhibition of hydrolase activity by sEH can result in sustained levels of epoxyeico- satrienoic acids ...
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Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex
... The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids ...C-terminal epoxide ...
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Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats
... Copyright © 2012 Abishek Iyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study
... Results: A total of 47 lipid mediators were consistently detected in BAL fluid of patients and controls. After false discovery rate adjustment, two products of the soluble epoxide hydrolase (sEH) ...
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Omega 6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis
... increased in joints with osteoarthritis (OA), but their associa- tion with OA progression is not yet well defined. To investi- gate the relationship between omega-6 FAs and knee OA, we measured with LC-MS the levels of ...
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Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome
... Soluble epoxide hydrolase (sEH) is an emerging target for pharmacological treatment of cardiovascular diseases be- cause the inhibition of sEH leads to increased circulating levels of ...
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Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease
... mice, soluble epoxide hydrolase deficient ( sEH −/− ) and two mouse models of AD, including amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic ( APP/PS1 Tg) and APP/PS1 Tg/ sEH −/− ...
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<p>Soluble epoxide hydrolase inhibition enhances anti-inflammatory and antioxidative processes, modulates microglia polarization, and promotes recovery after ischemic stroke</p>
... Epoxyeicosatrienoic acids (EETs), which are synthe- sized from arachidonic acid by cytochrome P450 epoxy- genases, have been proven to be bene fi cial in several disease models. In the cardiovascular system, EETs exhibit ...
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Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage
... 6 Genetic deletion or pharmacological inhibition of sEH attenuated thrombin- and hemin-induced microglial activation and proinflammatory responses in cultured microglia.. a Effects of sE[r] ...
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Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity
... and soluble epoxide hydro- lase (sEH) enzymes in the retina that are able to metabolize DHA into fatty acid mediators, which can affect cell viability (14) and angiogenesis (15, ...
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Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction
... Epoxyeicosatrienoic acids (EETs) are the main prod- ucts of arachidonic acid catalysis by the cytochrome P450s. EETs have a wide variety of cardioprotective ef- fects, such as causing marked vasodilation, inhibiting ...
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Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids
... Between January 2013 and Jun 2014, a total of 94 participants at Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University were initially enrolled in this study. 23 were the healthy volunteers, and 71 participants were ...
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Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection
... erythrocyte epoxide signaling ...rocyte epoxide signaling lipids, fatty acid preparations were iso- lated from the phospholipid fraction of erythrocytes infected with the PfEH1/2 double-knockout clones ...
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Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells
... and soluble epoxide hydrolase (sEH) mRNA and ...and epoxide hydro- lase activity: with arachidonic acid (stable epoxide products 5,6-DHET, and 14,15-DHET), linoleic acid (9,10-EPOME and ...
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Expression, purification, crystallization and preliminary X-ray diffraction analysis of conjugated bile salt hydrolase from Bifidobacterium longum
... Conjugated bile salt hydrolase (BSH) catalyses the hydrolysis of the amide bond that conjugates bile acids to glycine and to taurine. The BSH enzyme from Bi®dobacterium longum was overexpressed in Escherichia coli ...
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Transformations of hecogenin acetate
... Perchloric acid oatalysed rearrangement of t~e ring C epoxide§ The perchloric acid catalysed rearrangement of the 12 [3, 12' -epoxide in acetone-methylene chloride gave two products... T[r] ...
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The purification of fumarylacetoacetate hydrolase.
... Under this license, works must always be attributed to the copyright holder (original author), cannot be used for any commercial purposes, and may not be altered.. Any other use would [r] ...
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Tannase enzyme: The most promising biocatalyst for food processing industries
... acyl hydrolase, E.C.3.1.1.20) is an extracellular hydrolase enzyme that catalyzes the hydrolysis of ester and depside bonds in hydrolysable tannins or gallic acid esters, liberating glucose and gallic acid ...
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Reactions of 1,2 epoxyoctane
... Also in the mixture of aldehydes 17 and 18 was the undeuterated aldehyde 14 due to the presence of epoxide 6, 3% 14% estimated from nmr spectrum of dideuterated alkene and epoxide in the[r] ...
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