soluble RAGE
Effect of glycemic control on soluble RAGE and oxidative stress in type 2 diabetic patients
... of soluble RAGE (sRAGE), the extracellular ligand-binding domain of RAGE, which competes with RAGE for binding ...for RAGE than AGE-modified proteins ...
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RAGE and Soluble RAGE: Potential Therapeutic Targets for Cardiovascular Diseases
... of soluble RAGE is further supported by the findings that the sup- pression of sRAGE expression in dia- betic rat kidney was reversed by alage- brium blockade of AGEs accumulation ...of RAGE and ...
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Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis
... [22]. RAGE pos- sesses a secretory isoform known as soluble RAGE (sRAGE), which maintains the extracellular ligand-binding domain but lacks the cytosolic and transmembrane ...cell-bound RAGE, ...
8
Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
... In this first comparative study of sRAGE and esRAGE as markers of disease in type 2 diabetes, esRAGE concentra- tions were found to be ~ 5 times lower than total sRAGE concentrations, but correlated significantly with ...
5
Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study
... both soluble variants of RAGE work as decoys for AGEs, reducing RAGE signal- ing and inflammation ...of soluble variants of RAGE both lower [18–20] and higher [21–23] than controls have ...
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Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control
... of soluble receptor for advanced glycation end products (soluble RAGE) in blood and synovial fluid (SF) of rheumatoid arthritis (RA) patients and in patients with degenerative/traumatic joint ...
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The potential role of advanced glycation end products (AGEs) and soluble receptors for AGEs (sRAGE) in the pathogenesis of adult onset still’s disease
... [9-12]. Soluble RAGE (sRAGE), the extracellular domain of RAGE, is generated by two distinct mecha- nisms, the splice variant [endogenous secretory RAGE (esRAGE)] secretion and cleavage of ...
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Original Article Impact of hyperglycemia and acute pancreatitis on the receptor for advanced glycation endproducts
... length RAGE or by alternative splicing of the pre-mRNA of RAGE ...[20-25]. Soluble RAGE (sRAGE) has been demonstrated to inhibit inflammation in several pathological processes such as athero- ...
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Multimodal imaging of the receptor for advanced glycation end-products with molecularly targeted nanoparticles
... of RAGE through attenuating RAGE ...of RAGE ligands, such as advanced glycation end products (AGEs), or by blocking the binding of RAGE with its ligands [10, ...membrane-bound RAGE ...
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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
... to RAGE results in rapid and sustained cellular activation and gene transcription ...First, RAGE is upregulated in all inflammatory lesions studied, including rheumatoid arthri- tis (26–28), inflammatory ...
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Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE
... two RAGE antagonists were not responsible for the observed phenotype, we sought to corroborate the RAGE antagonist results in knockout ...DIO RAGE KO mice had similarly elevated levels of fasting ...
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RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity
... apoptosis. RAGE selectively bound toxic intermediates, but not nontoxic forms of h-IAPP, including amyloid ...of soluble RAGE (sRAGE) blocked both h-IAPP toxicity and amyloid ...and RAGE by ...
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Serum Levels of sRAGE, the Soluble Form of Receptor for Advanced Glycation End Products, Are Associated with Inflammatory Markers in Patients with Type 2 Diabetes
... cell-surface RAGE or novel splice variants of RAGE (16,21,22, ...C-truncated RAGE; C-truncated RAGE levels in Koyama et ...C-truncated RAGE could differ in diabetic ...C-truncated ...
5
Blockade of RAGE suppresses periodontitis associated bone loss in diabetic mice
... Analysis of gingival tissue for AGEs. At sacrifice, gingival tissue was removed, fixed in buffered formalin (10%), and then paraffin-embedded sections, 5-µm thick, were prepared. Immunohistochemistry was performed using ...
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Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice
... fied by Southern blotting (A) and by PCR (B). Lanes 1 and 6, lack of PPET DN-RAGE expression; lanes 2–5, expressing PPET DN-RAGE; C, control; M, base pair size marker. (C) Aortas were retrieved from the ...
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Sensory neuronal sensitisation occurs through HMGB 1/RAGE and TRPV1 in high glucose conditions
... condition, RAGE activation by AGEs is driven by molecules such as methylglyoxal, resulting in cellular damage, and further complications (Hidmark et ...2014). RAGE is a pattern recognition receptor that is ...
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Central role of RAGE dependent neointimal expansion in arterial restenosis
... that RAGE-dependent mechanisms in modula- tion of SMC properties are engaged within the first hours to days after injury; indeed, administration of sRAGE was ineffective when first initiated beyond the 7 days ...
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High mobility group box 1 and the receptor for advanced glycation end products contribute to lung injury during Staphylococcus aureus pneumonia
... and RAGE in lung injury accompanying the early phase of ...pneumonia. RAGE deficiency, however, was associated with reduced lung pathology and inflammation as well, suggesting that both HMGB1 and ...
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The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis
... CHO cells transfected with RAGE and GFP-tagged PRAK were washed with PBS and lysed with 1 % CHAPS buffer (Sigma). To reduce non-specific binding, pre-clearing with protein A/G agarose (Santa Cruz Biotechnology) ...
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RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice
... against RAGE (RAGE-aptamer) on growth and liver metastasis of G361 melanoma in nude ...of RAGE-aptamer ...d. RAGE-aptamer significantly reduced levels of 8-hydroxy-2’-deoxy-guanosine, AGEs, ...
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