Soluble RAGE (sRAGE)
Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis
... [22]. RAGE pos- sesses a secretory isoform known as soluble RAGE (sRAGE), which maintains the extracellular ligand-binding domain but lacks the cytosolic and transmembrane ...domains. ...
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Effect of glycemic control on soluble RAGE and oxidative stress in type 2 diabetic patients
... of soluble RAGE (sRAGE), the extracellular ligand-binding domain of RAGE, which competes with RAGE for binding ...of sRAGE in diabetic animals following induction of diabetes ...
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RAGE and Soluble RAGE: Potential Therapeutic Targets for Cardiovascular Diseases
... plasma sRAGE or esRAGE and AGEs ...of soluble RAGE is further supported by the findings that the sup- pression of sRAGE expression in dia- betic rat kidney was reversed by alage- brium ...
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Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study
... AGE- RAGE-esRAGE axes is only partly understood. RAGE is subject to regulated intramembrane proteolysis by ADAM10 (a disintegrin and metalloproteinase 10), shedding the cleaved variant of sRAGE in a ...
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Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
... Total sRAGE antigen (R&D Systems, Wiesbaden, Germany) and esRAGE (B-Bridge International, Sunnyvale, USA) antigen were detected in plasma in duplicates by Elisa according to the manufacturer's ...with ...
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Soluble receptor for advanced glycation end product (sRAGE)/pentosidine ratio: a potential risk factor determinant for Type 2 diabetic retinopathy
... [9,10]. Soluble RAGE (sRAGE), a RAGE isoform lacking the transmembrane domain, is a recently discovered inhibitor of AGE-RAGE mediated pathological effects ...between sRAGE and ...
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S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study
... [16–18] RAGE can be cleaved by proteolysis, resulting in the circulation of its soluble ...component. Soluble RAGE (sRAGE) acts as a decoy receptor, which can be rapidly released after ...
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Soluble receptor for advanced glycation end products in critically ill patients and its associations with other clinical markers and 28-day mortality
... signaling. Soluble RAGE (sRAGE), a newly identified subtype of RAGE, is considered a truncated isoform of ...Specifically, sRAGE is formed after undergoing proteolytic cleavage to ...
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Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control
... cell-bound RAGE functions as a counter-receptor for leukocyte integrins, thereby being directly involved in leukocyte recruitment, especially in inflammatory conditions when the receptor expression increases ...
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Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12, and VCAM 1 Levels with Further Post Coronary Angiogram Endothelial Injury in Elderly and Younger Patients
... of sRAGE, VCAM-1, as well as S100A12 pre- and post-coronary angiography alongside likelihood of endothelial injury among various patients in different ages in- cluding the younger and the geriatric groups, thereby ...
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Association of serum soluble receptor for advanced glycation end products (sRAGE), S100A12, and VCAM-1 levels with further post-coronary angiogram endothelial injury in patients with Coronary Artery Disease (CAD) and stenosed coronary vessels
... occlusion. Soluble RAGE (sRAGE), VCAM-1 and S100A12 levels in blood samples collected after CAG session were measured to assess the inflammatory responses and possibility of endothelial injury ...
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Evolution and bad prognostic value of advanced glycation end products after acute heart failure: relation with body composition
... and sRAGE levels with respect to parameters of obesity such as BMI or BF ...that sRAGE levels were inversely related to BMI in severely obese subjects [21], in young adults [22] and in subjects with ...
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Multimodal imaging of the receptor for advanced glycation end-products with molecularly targeted nanoparticles
... of RAGE through attenuating RAGE ...of RAGE ligands, such as advanced glycation end products (AGEs), or by blocking the binding of RAGE with its ligands [10, ...membrane-bound RAGE ...
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The potential role of advanced glycation end products (AGEs) and soluble receptors for AGEs (sRAGE) in the pathogenesis of adult onset still’s disease
... [9-12]. Soluble RAGE (sRAGE), the extracellular domain of RAGE, is generated by two distinct mecha- nisms, the splice variant [endogenous secretory RAGE (esRAGE)] secretion and cleavage ...
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Original Article Impact of hyperglycemia and acute pancreatitis on the receptor for advanced glycation endproducts
... length RAGE or by alternative splicing of the pre-mRNA of RAGE ...[20-25]. Soluble RAGE (sRAGE) has been demonstrated to inhibit inflammation in several pathological processes such as ...
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sRAGE in diabetic and non diabetic critically ill patients: effects of intensive insulin therapy
... recombinant soluble RAGE atte- nuated intestinal dysfunction in mouse models of resus- citated hemorrhagic shock and lipopolysaccharide (LPS)-induced lung injury ...[12,18]. RAGE knockout mice were ...
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The presence of high mobility group box-1 and soluble receptor for advanced glycation end-products in juvenile idiopathic arthritis and juvenile systemic lupus erythematosus
... membrane RAGE on monocytes, macrophages and other cells is overexpressed in response to increasing concentra- tion of its ligand HMGB1 and triggers inflammatory im- mune ...Moreover, RAGE also exists in a ...
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A REVIEW ON DIABETES INDUCED MEMORY IMPAIRMENT
... 3) Amyloid beta aggregation inhibitors: The neurotoxic effect of amyloid beta has been documented on numerous occasions and thus decreasing its neurotoxicity or inhibiting its aggregation may have therapeutic potentials. ...
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Narratives of Rage and Rehabilitation: Hyper Marginality and the Strategies of Resistance in Jamaica Kincaid’s My Brother and Mr. Potter
... Kincaid’s Mr. Potter (2002) is in many ways similar to My Brother. Both My Brother and Mr. Potter evoke strongly the images of death and they are thus narratives of loss and mourning. Further, both have a male figure as ...
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Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki disease
... Serum levels of resistin, S100A12, and sRAGE in IVIG responder and non-responder KD patients are shown in Table 2 and Figure 1. Not all KD patients were sensitive to the treatment of IVIG. There were four ...
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