soluble thrombomodulin
Benefit profile of recombinant human soluble thrombomodulin in sepsis induced disseminated intravascular coagulation: a multicenter propensity score analysis
... human soluble thrombomodulin (rhTM) have been demonstrated, with promising evidence suggestive of efficacy for patients with severe sepsis involving coagulopathy in a phase IIb randomized controlled ...
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Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin
... 10. Vincent JL, Ramesh MK, Ernest D, Larosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi ...
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Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study
... human soluble thrombomodulin (rhTM) binds to thrombin to inacti- vate coagulation, and the thrombin-rhTM complex acti- vates protein C to produce activated protein C (APC), which, in the presence of protein ...
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Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model
... Introduction Recombinant human soluble thrombomodulin (rhsTM) is newly developed for the treatment of DIC. The purpose of this study was to evaluate the efficacy of the concomitant administration of rhsTM ...
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Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study
... Recombinant human soluble thrombomodulin (rhTM) is the only agent for the treatment of DIC [12]. rhTM was approved in 2008 and has been used clinically for DIC treatment in Japan. Several animal studies ...
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Recombinant human soluble thrombomodulin administration improves sepsis-induced disseminated intravascular coagulation and mortality: a retrospective cohort study
... human soluble thrombomodulin decreases thrombin-antithrombin complex compared with heparin Table 2 Independent variables in final multiple regression models by Cox regression ...
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Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study
... and soluble thrombomodulin (sTM) circulates at low levels ...endothelial thrombomodulin and simultaneously increased plasma sTM as compared to controls ...
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Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial
... C. Thrombomodulin has anti-inflammatory as well as high mobility group box 1 (HMGB1) inhibitory and anticoagulant activities [10, ...human soluble thrombomodulin (rhTM) demonstrates anticoagulation ...
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The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study
... human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent composed of the active, extracellular domain of thrombomodulin (TM) that reg- ulates the imbalanced coagulation system by reducing ...
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The Concept Study of Recombinant Human Soluble Thrombomodulin in Patients with Acute Respiratory Distress Syndrome
... The modulation of the coagulation disturbance by our conventional therapy with rhTM administration may be related to the mortality of ARDS patients, because the serial changes in the fib[r] ...
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Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin
... Endothelial injury is a key feature of sepsis, and the activation and damage of endothelial cells are closely linked with organ dysfunction [6, 7]. Previous studies highlighted systemic hypotension and ischemia- ...
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Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients
... Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and dissemi- nated intrav[r] ...
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Thrombomodulin is present in human plasma and urine
... of thrombomodulin that is ...ng thrombomodulin/ml plasma and 102 +/- 38 ng thrombomodulin/ml ...urine. Thrombomodulin was isolated from both plasma and urine by immunoaffinity chromatography ...
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sRAGE in diabetic and non diabetic critically ill patients: effects of intensive insulin therapy
... released soluble form ...and soluble thrombomodulin (as markers of inflammation and endothelial cell injury, respectively) were evaluated in ICU, at Days 1, 3, 5 and ...
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Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation
... TM: Thrombomodulin; APC: Activated protein C; rTM: Recombinant human soluble thrombomodulin; rhAPC: Recombinant human activated protein C; DIC: Disseminated intravascular coagulation; TF: Tissue ...
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Benefit profile of anticoagulant therapy in sepsis: a nationwide multicentre registry in Japan
... Sepsis invariably leads to haemostatic abnormalities through the activation of inflammatory mediators and vascular endothelial cell injury, which play a critical role in inducing multiple organ dysfunction syndrome and ...
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Impaired Flow-Mediated Vasodilation, Carotid Artery Intima-Media Thickening, and Elevated Endothelial Plasma Markers in Obese Children: The Impact of Cardiovascular Risk Factors
... Germany). Soluble thrombomodulin was assayed using a sandwich enzyme immunoassay (Diagnostica Stago, Asnieres-Sur-Seine, ...France). Thrombomodulin recog- nized by a mouse monoclonal antibody coated ...
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Management of disseminated intravascular coagulation: current insights on antithrombin and thrombomodulin treatments
... Abstract: Sepsis and septic shock are frequently complicated by disseminated intravascular coagulation (DIC), which decreases the survival rate of patients with sepsis. In the past, large international randomized ...
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Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation
... of this new agent has been repeatedly evaluated. For example, Yamakawa et al. [18] reported a trend toward favorable outcomes in their systematic review based on a meta-analysis. They collated data from 12 studies (838 ...
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Cell adhesion factors in cnidarians
... Appendix B Sub Family C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Soluble C-type Solu[r] ...
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