Solute carrier
Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma
... The solute carrier (SLC) 7 family genes comprise 14 genes. The gene family can be divided into two sub- groups, the cationic amino acid transporters (SLC7A1-4) and glycoprotein-associated transporters (SLC7 ...
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Aberrant Hypomethylation of Solute Carrier Family 6 Member 12 Promoter Induces Metastasis of Ovarian Cancer
... Fig. 2. Alteration of DNA methylation of the CpG sites of SLC6A12 in tumor metastases from ovarian cancer xenograft mice. The DNA methylation sta- tus of the SLC6A12 promoter region was analyzed using the Illumina ...
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Original Article Genetic screening of solute carrier family 5 member 5( SLC5A5 ) gene in Chinese Han congenital hypothyroidism patients with goiter
... Congenital hypothyroidism (CH) is a common congenital endocrine disorder with a preva- lence range from 1 in 3000 to 1 in 4000 in live newborns worldwide [1]. If left untreated it is one of the most significant causes of ...
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Embryonic expression of Xenopus SGLT 1L, a novel member of the solute carrier family 5 (SLC5), is confined to tubules of the pronephric kidney
... the solute carrier (SLC) superfamily, which is currently comprised of 37 different transporter families (Human Gene Nomenclature Database; http:// ...
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The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes
... Metabolic reprogramming has been readily accepted as part of the revised hallmarks of cancer where tumour cells are able to modulate their metabolic pathways to support their unremitting proliferation (Hanahan, 2011). ...
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Analysis and update of the human solute carrier (SLC) gene superfamily
... the solute- carrier (SLC) gene superfamily — and include passive transporters, symporters and antiporters, as well as mitochondrial and vesicular ...
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Pathway annotation and analysis with Reactome: The solute carrier class of membrane transporters
... Reactome is an expert-authored, peer-reviewed knowledge base of human reactions and pathways that functions as a data-mining resource and electronic textbook. Its current release covers approximately 23 per cent of the ...
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Solute carrier transporters: potential targets for digestive system neoplasms
... world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs and tissues of digestive systems and mediate specific uptake of small molecule ...
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The significance of solute carrier group of genes in the pathogenesis and treatment of diabetic microvascular complications
... The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 65 families [12, 13]. Most members of the SLC group are located in the cell membrane, but some are ...
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Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction
... In summary, PLP mutations are known to result in dysfunction of the complex organelle interplay of per- oxisomes, mitochondria and ER thereby affecting traf- ficking of critical membrane proteins and phospholipids. While ...
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Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes.
... The aim of this study was to determine if the polymorphisms rs7799039 and rs13266634 were associated with gestational diabetes in a case-control study with healthy and diabetic Euro[r] ...
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SLC26A9 mediated chloride secretion prevents mucus obstruction in airway inflammation
... the solute carrier family 26, member 9 (SLC26A9) Cl – channel in asthma, we induced Th2-mediated inflammation via IL-13 treatment in wild-type and Slc26a9-deficient mice and compared the effects on airway ...
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Zinc, insulin, and the liver: a ménage à trois
... A link between zinc transport and diabetes The ZnT8 transporter encoded by solute carrier family 30 member 8 gene; SLC30A8 is located on dense core vesicles DCVs in β cells and loads Zn2[r] ...
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Genome wide association study of antidepressant response: involvement of the inorganic cation transmembrane transporter activity pathway
... in both samples for remission are shown in Additional file 7: Table S5 and we underline the presence of the following genes: 1 SLC6A3 solute carrier family 6 member gene 3, that codes fo[r] ...
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The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients
... Methods: We investigated the association between solute carrier family 2 (facilitated glucose transporter), member 1 - 2841A>T, hypoxia-inducible factor 1 alpha Pro582Ser, Ala588Thr, [r] ...
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Investigating the biological role of human NEIL3
... Homo sapiens coiled-coil domain containing 88A CCDC88A, transcript variant 2, mRNA Homo sapiens solute carrier family 25 mitochondrial carrier; phosphate carrier, member 3 SLC25A3, nucle[r] ...
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A novel homozygous stop gain mutation in SLC12A3 gene cause Gitelman syndrome in Saudi consanguineous family
... the solute carrier family 12-member 3 (SLC12A3) gene that encodes thiazide-sensitive sodium-chloride cotransporter and to date more than 400 deleterious mutations have been identified in SLC12A3 gene so far ...
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Mycobacterium avium subspecies paratuberculosis—An environmental trigger of type 1 diabetes mellitus
... Natural resistance-associated macrophage protein 1 (NRAMP1) is now strictly referred to as SLC11A1 (solute carrier 11a1). The gene that encodes for this protein is recognized as having a role in the ...
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Cloning and functional expression of the first eukaryotic Na+–tryptophan symporter, AgNAT6
... the solute carrier family 6, SLC6) represents transport mechanisms with putative synergistic roles in the absorption of essential and conditionally essential neutral amino ...
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Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11 year retrospective cohort study
... including solute carrier family 11 (proton-coupled divalent metal ion trans- porters), member 1 (SLC11A1) operating at the level of the macrophage, were associated with the later develop- ment of TB in HIV ...
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