somatostatin analogs
A review of the use of somatostatin analogs in oncology
... Abstract: Somatostatin is a neuropeptide produced by paracrine cells that are located throughout the gastrointestinal tract, lung, and pancreas, and is also found in various locations of the ner- vous ...stable ...
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A case of malignant insulinoma responsive to somatostatin analogs treatment
... The fasting test was performed, which was interrupted after 12 h due to the onset of symptomatic hypoglycemia (44 mg/dl, glucometer measurement). Plasma glucose level was 41 mg/dl, insulin level 16.3 U/L and C-peptide ...
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“Somatostatin Analogs, How Biomarkers in the Diagnostic and Treatment for Cancer and Others Damages” by Eva María Molina Trinidad, Andrés Salas Casas, Mexico.
... the somatostatin receptor, especially receptor subtype-2, have been ...of analogs implies a fragmented knowledge on the interpretation of the images that are obtain in clinical ...radiolabeled ...
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18F-FDG and 68Ga-somatostatin analogs PET/CT in patients with Merkel cell carcinoma: a comparison study
... Ga-somatostatin analogs provided comparable re- sults in terms of sensitivity (100%) and specificity (86 and 71%, ...matostatin analogs), although 68 Ga-SRI PET/CT failed to detect two liver lesions ...
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Clinical applications of somatostatin analogs for growth hormone-secreting pituitary adenomas
... includes somatostatin analogs (SAs) and GH receptor antagonist; the former consists of lanreotide Autogel (ATG) and octreotide long-acting release (LAR), and the latter refers to ...
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A clinical and radiological objective tumor response with somatostatin analogs (SSA) in well-differentiated neuroendocrine metastatic tumor of the ileum: a case report
... Abstract: Somatostatin analogs (SSAs) are typically used to treat the symptoms caused by neuroendocrine tumors (NETs), but they are not used as the primary treatment to induce tumor ...
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Prognostic significance of AKT/mTOR signaling in advanced neuroendocrine tumors treated with somatostatin analogs
... This clinical study was single-center, retrospective, and included samples obtained from a cohort of 23 patients with metastatic NET followed at the Department of Medical Oncology, Hospital de Santa Maria (HSM), Lisbon. ...
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Original Article Safety and tolerability of sequencing somatostatin analogs (octreotide to lanreotide depot) in the treatment of neuroendocrine tumors: an institutional case series
... to somatostatin receptors 2 and 5 [8], is currently indicated in the United States for the treatment of acromeg- aly and severe diarrhea/flushing episodes associated with metastatic carcinoid tumors [1]; although ...
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Long-term treatment of somatostatin analog-refractory growth hormone-secreting pituitary tumors with pegvisomant alone or combined with long-acting somatostatin analogs: a retrospective analysis of clinical practice and outcomes
... However, in Group 2 patients whose end-of- follow-up IGF-I levels were still elevated, the final PEGV doses were significantly higher than those used in non- normalized patients in Group[r] ...
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Budget impact of somatostatin analogs as treatment for metastatic gastroenteropancreatic neuroendocrine tumors in US hospitals
... To assist in identifying the optimal treatment for patients with locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors, budget impact modeling was used to estimat[r] ...
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Structure Activity Relationships of Somatostatin Analogs in the Rabbit Ileum and the Rat Colon
... Somatostatin increases absorption of electrolytes and inhibits diarrhea in patients with endocrine tumors and short bowel syndrome. In an attempt to develop a gut-specific somatostatin analog, each amino ...
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Somatostatin analog challenge test in the pre-surgical management of ACTH-secreting pheochromocytoma
... of somatostatin analogs published so far have yielded conflicting results (4, 5), due, at least in part, to the wide heterogeneity of SSTRs expression in the tumor and to their different affinity to the ...
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[111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study
... Therefore, we have decided to couple DOTA to the N- terminus of native and non-modified SS14. In this way, AT1S was first generated with the purpose to serve as a lead compound to future structurally modified pansoma- ...
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Multimodal Somatostatin Receptor Theranostics Using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octreotate and AN-238 in a Mouse Pheochromocytoma Model
... Taken together, the present preclinical and accumulating clinical findings provide a basis for trials directed to radionuclide therapies targeting SSTR2 in metastatic PHEO/PGL. At the same time given the likelihood of ...
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THERANOSTICS: From Molecular Imaging Using Ga-68 Labeled Tracers and PET/CT to Personalized Radionuclide Therapy - The Bad Berka Experience
... DOTA-conjugated somatostatin analogs, for providing the activity (Y-90 DOTATOC) for the first patient treatment in Germa- ny, a number of peptides for clinical trials and for many fruitful scientific ...
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Exogenous Cyclic AMP, Cholera Toxin, and Endotoxin Induce Expression of the Lipopolysaccharide Receptor CD14 in Murine Bone Marrow Cells: Role of Purinoreceptors
... Although a number of studies were conducted to analyze LPS signaling in fully differentiated cells, little is known about the signaling pathways by which LPS induces the expression of new surface molecules or receptors ...
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Insulin glulisine in the management of diabetes
... So far, there are few clinical studies of insulin glulisine. Firm conclusions cannot therefore be made on the utility of this new insulin analog. However, as mentioned above, insulin glulisine appears to have the most ...
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Design, Synthesis and Study of Novel Nucleobase Analogs
... 7-deazaadeine analogs substituted at the 7-position with various fluorescent alkynes is an area of research that is yet to be explored in the context of ...
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Preliminary Report on Somatostatin Receptor Imaging in Rare Endocrine Tumours
... Preliminary Report on Somatostatin Receptor Imaging in Rare Endocrine Tumours ORIGINAL ARTICLE Preliminary Report on Somatostatin Receptor Imaging in Rare Endocrine Tumours BJJ Abdullah, FRCR*, M Para[.] ...
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Somatostatin related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel
... Four somatostatin-related peptides were isolated from eel ...small somatostatin (eSS-14II), the 11 N- terminal amino acid residues seem to potentiate somatostatin action in the eel ...
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