Somatostatin and SSTR2
Somatostatin Receptor Type 2 (SSTR2) Antagonism and Hypoglycemia in Diabetes
... nmol/kg/h, SSTR2 antagonist had no effect on glucagon responses to hypoglycemia in non-diabetic ...that somatostatin does not play a role in suppressing glucagon release in non-diabetic rats, but taken ...
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Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea
... Abstract Somatostatin (SST) is a peptide hormone that ex- erts inhibitory effects mediated through binding to specific cell surface G protein-coupled receptors, of which five distinct subtypes (SSTR1-SSTR5) have ...
11
Somatostatin receptor subtype specificity in human fetal pituitary cultures Differential role of SSTR2 and SSTR5 for growth hormone, thyroid stimulating hormone, and prolactin regulation
... both SSTR2 and SSTR5, PRL release from human fetal lactotropes or mammosomatotropes is af- fected mainly through ligand binding to ...for SSTR2 inhibited PRL with greater potency than did SRIF-14 or ...
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Anti inflammatory SSTR2 ligands
... Somatostatin is one of a group of hormones known as hypothalamus releasing factors. These are hormones of hypothalmic origin and affect the release of pituitary hormones. The hypothalamus effectively links the ...
329
Membrane-displayed somatostatin activates somatostatin receptor subtype-2 heterologously produced in Saccharomyces cerevisiae
... human SSTR2 that was het- erologously produced in yeast ...displayed somatostatin was successfully ...rat SSTR2 (Price et ...human SSTR2 in ...
8
A poles apart applications of somatostatin hormone
... cloned somatostatin receptor subtypes has been examined using several procedures which differ in sensitivity, in- cluding RNA (northern) blotting, RNAase protection, and reverse transcriptase-polymerase chain ...
14
SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males
... Background: Somatostatin receptor 2 ( SSTR2 ) encodes somatostatin receptor that can inhibit the cell proliferation of solid ...between SSTR2 promoter methylation and the risk and progression ...
6
Somatostatin Receptor Expression in GH-Secreting Pituitary Adenomas Treated with Long-Acting Somatostatin Analogues in Combination with Pegvisomant
... lower SSTR2 IRS compared to the naive group. Noteworthy, the SSTR2 IRS was almost significantly different (p = ...of SSTR2 in the combined treatment group compared to the mono-LA-SSA and naive ...of ...
10
Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201 995 in treatment of human endocrine tumors
... In two cases of glucagonoma and its metastatic lymph nodes in one case, all the SSTR subtype mRNAs except SSTR5 mRNA were expressed. In four cases of insulinoma, SSTR1 and SSTR4 mRNAs were detected, but SSTR2 mRNA ...
6
Somatostatin receptor based hybrid imaging in sarcoidosis
... The somatostatin receptor subtype 2 (SSTR2) is highly expressed in sarcoid ...high SSTR2 receptor expression is beneficial for somatostatin receptor scintigraphy (SRS) using 111 ...
5
"[125I-Tyr']somatostatin in native somatostatin (final concentration,
... ABSTRACT Thymosin (34, recently isolated from calf thymus, is present in a number of rat and mouse tissues, including spleen, thymus, brain, lung, liver, and heart muscle.. High concentr[r] ...
5
Properties of endogenous somatostatin like immunoreactivity and synthetic somatostatin in dog plasma
... https://doi.org/10.1172/JCI109238. Somatostatin-like immunoreactivity (SLI) in the peripheral venous plasma of dogs and in their pancreatic and gastric venous effluents was characterized and compared with ...
8
Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors
... The prepared citrate-AuNPs, MUA-AuNPs and AuNPs coated with different concentrations of SST were examined for their size, polydispersity and surface charge... For Pee[r] ...
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Effects of Somatostatin on Gallbladder Emptying
... The purpose of this study was to investigate the effects of somatostatin on the gallbladder emptying responses to liquid and solid meals, sham feeding, cholinergic [r] ...
Radiopharmaceuticals for somatostatin receptor imaging
... in somatostatin receptor targeting radiopeptides resulted in much better image quality, higher sensitivity of tumor detection and lower mean effective dose for the examined ...in somatostatin receptor ...of ...
7
A high molecular weight form of somatostatin 28 (1 12) like immunoreactive substance without somatostatin 14 immunoreactivity in the rat pancreas Evidence that somatostatin 14 synthesis can occur independently of somatostatin 28
... Synthesis of somatostatin-14 (S-14) could occur through direct enzymatic processing of precursor somatostatin (prosomatostatin) or via sequential breakdown of prosomatostatin leads to so[r] ...
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Selective binding of somatostatin 14 and somatostatin 28 to islet cells revealed by quantitative electron microscopic autoradiography
... These observations show preferential association of S-14 section with the A cell and S-28 section with the B cel provide strong evidence for the existence of separate binding sites for S[r] ...
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Inhibition of gastrin gene expression by somatostatin
... demonstrated somatostatin-containing cells in close proximity to gastrin cells in antral mucosa and have shown that somatostatin exerts a local regulatory effect on gastrin ...of somatostatin on the ...
7
A review of the use of somatostatin analogs in oncology
... Abstract: Somatostatin is a neuropeptide produced by paracrine cells that are located throughout the gastrointestinal tract, lung, and pancreas, and is also found in various locations of the ner- vous ...of ...
13
Detection of somatostatin receptors in human osteosarcoma
... expressing somatostatin receptors had a more deleterious course with a very low disease-free and overall survival rate compared to osteosarcoma with negative receptor status, even though the percentage (14%) was ...
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