Sonic hedgehog
A highlight on Sonic hedgehog pathway
... Abstract: Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and ...that Sonic hedgehog (Shh) pathway is important for the evolution of radio and ...
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FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
... ligand sonic hedgehog (SHH), which is produced by cells at the ventral midline of the spinal cord (notochord and floor plate), controls neural fate specification by signaling to cells and regulating their ...
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Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity
... diencephalon, sonic hedgehog (Shh) is expressed in the ventral midline of prosomeres 1-3 (p1-p3), which underlie the pretectum, thalamus and prethalamus, ...
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Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon
... Fig. 8. Three actions of sonic hedgehog on embryonic telencephalon development. (A) Early in development (~E9.0-E12.5), Shh forms a reciprocal gradient with the repressor form of Gli3. The relative ...
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Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes
... One of the most perplexing questions in clinical genetics is why patients with identical gene mutations often- times exhibit radically different clinical features. This inconsistency between genotype and phenotype is ...
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Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction
... the Hedgehog morphogen signal emanating from the embryonic midline is critical for correct patterning of the ven- tral neural tube ...the Sonic hedgehog protein (sarcopterygians and fishes with- out ...
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Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos
... Int I Dc\' Riol ~O 929 940 (1996) 929 Original A/tide Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos UWE STRAHLE', PATRICK BLADER' and PHILIP W INGHAM" Mole[.] ...
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Microparticles Carrying Sonic Hedgehog Are Increased in Humans with Peripheral Artery Disease
... Abstract: Sonic Hedgehog (Shh) is a prototypical angiogenic agent with a crucial role in the regulation of angiogenesis. Experimental studies have shown that Shh is upregulated in response to ischemia. ...
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Sonic hedgehog signalling from foregut endoderm patterns the avian nasal capsule
... Lineage experiments have shown that Hox-negative cephalic neural crest cells (CNCCs) emigrating from the prosencephalic and the anterior mesencephalic neural folds give rise to the nasal capsule and to first pharyngeal ...
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Distinct temporal requirements for Sonic hedgehog signaling in development of the tuberal hypothalamus
... Sonic hedgehog (Shh) plays well characterized roles in brain and spinal cord development, but its functions in the hypothalamus have been more difficult to elucidate owing to the complex neuroanatomy of ...
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Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix
... and hedgehog (Hh) proteins, are potential ...in sonic hedgehog (Shh) have increased enteric neurons and abnormally distributed ...indian hedgehog (Ihh) leads to segmental aganglionosis in ...
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Genomic characterization of Gli activator targets in sonic hedgehog mediated neural patterning
... One crucial role of sonic hedgehog (Shh) lies in patterning of the vertebrate neural tube. Here, Shh secreted from the midline notochord acts as a morphogen to specify five classes of ventral neuronal ...
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Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine
... The Hedgehog (Hh) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of ...conditions, Sonic Hedgehog (Shh), a secreted ...
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The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling
... abnormal sonic hedgehog (Shh) signaling and all present with malformations of the anterior pituitary gland and midline structures of the anterior cranial ...
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Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions
... morphogen Sonic hedgehog (Shh), initially expressed in the prechordal plate, is essential for this inductive ...and Hedgehog protein can induce hypothalamic tissue in forebrain explants ...
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Understanding the role of the Sonic Hedgehog signaling pathway in cerebellar development and medulloblastoma genesis
... Sonic hedgehog pathway in granule neuron precursor proliferation and foliation The Shh ligand secreted by the Purkinje cells around E17 is responsible for the high degree of proliferation of GNPs in the ...
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Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
... Background: Primary cilia are small non-motile microtubule and cell membrane protrusions expressed on most vertebrate cells, including cortical and hippocampal neurons. These small organelles serve as sensory structures ...
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A direct fate exclusion mechanism by Sonic hedgehog regulated transcriptional repressors
... Sonic hedgehog (Shh) signaling patterns the vertebrate spinal cord by activating a group of transcriptional repressors in distinct neural progenitors of somatic motor neuron and interneuron ...
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Sonic hedgehog is a critical mediator of erythropoietin induced cardiac protection in mice
... that sonic hedgehog is a critical mediator of erythropoietin-induced cardioprotection in ...of sonic hedgehog in cardiomyocytes, and inhibition of sonic hedgehog signaling ...
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Distinct Temporal Requirements For Sonic Hedgehog In The Development Of The Tuberal Hypothalamus
... Sonic hedgehog (Shh) is a secreted morphogen that plays integral roles in the development of several brain and spinal cord ...the Hedgehog transducer Smoothened (Smo) at time points after ...
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