Spastic paraparesis
Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy.
... 16. Jacobson, S., V. Zaninovic, C. Mora, P. Rodgers-Johnson, W. A. Sheremata, Jr., C. Gajdusek, and D. E. McFarlin. 1988. Immunological findings in neurological diseases associated with antibodies to HTLV-I: activated ...
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Anti HTLV antibody profiling reveals an antibody signature for HTLV I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
... Human T lymphotropic virus type I (HTLV-I) is a retrovi- rus that infects 20 million people worldwide [1]. HTLV-I infection can cause a variety of human diseases including adult T-cell leukemia/lymphoma (ATLL) [2-4], ...
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Microstructural Integrity of Cerebral Fiber Tracts in Hereditary Spastic Paraparesis with SPG11 Mutation
... In this study, we selected the CST for tract-specific analysis because most of the fibrils here align in the rostral-caudal di- rection instead of reciprocal innervations. We consistently ob- served a progressive ...
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Potential oligogenic disease of mental retardation, short stature, spastic paraparesis and osteopetrosis
... Abstract: The interaction of multiple genetic factors, as opposed to monogenic inheritance, has been suspected to play a role in many diseases. This interaction has been described as an oligo- genic inheritance model, ...
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Effects of host restriction factors and the HTLV 1 subtype on susceptibility to HTLV 1 associated myelopathy/tropical spastic paraparesis
... Abstract Background: Although human T-lymphotropic virus type 1 HTLV-1 infection is a prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis HAM/[r] ...
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Marked Suppression of T Cells by a Benzothiophene Derivative in Patients with Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis
... myelopathy/tropical spastic paraparesis (HAM/TSP) spontaneously proliferate in vitro, and their activation is reported to be associated with CD54 ...
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CD80+ and CD86+B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis
... Human T-cell lymphotropic virus 1 (HTLV-1) was the first human retrovirus to be isolated [1]. In contrast to HIV, the provirus preferentially replicates through oligo- clonal proliferation of infected cells rather than ...
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Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
... Case presentation: Here, we described the clinical presentations, muscle biopsy studies and laboratory results of two siblings with HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) who ...
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Plasma proteome analysis in HTLV 1 associated myelopathy/tropical spastic paraparesis
... Background: Human T lymphotropic virus Type 1 (HTLV-1) causes a chronic inflammatory disease of the central nervous system known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM) which ...
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Immunovirological markers in HTLV 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
... Human T cell lymphotropic virus 1 (HTLV‑1) is a human retrovirus and infects approximately 10–20 million people worldwide. While the majority of infected people are asymptomatic carriers of HTLV‑1, only 4% of infected ...
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Functional capacity of natural killer cells in HTLV 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients
... Methods: This cross-sectional study sequentially recruited HTLV-1 infected individuals with HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP) and asymptomatic HTLV-1 (AS) from the ...
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Real-world clinical course of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Japan
... myelopathy/tropical spastic paraparesis (HAM/TSP) is a rare chronic neurological disease, large scale studies to collect continuous clinical data have been difficult to ...
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Increased expression of OX40 is associated with progressive disease in patients with HTLV 1 associated myelopathy/tropical spastic paraparesis
... myelopathy/tropical spastic paraparesis (HAM/TSP) ...by spastic paraparesis, sphincter dysfunc- tion, and mild sensory disturbance in the lower extrem- ities ...
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Diagnosis of spinal xanthomatosis by next-generation sequencing: identifying a rare, treatable mimic of hereditary spastic paraparesis.
... of precursor molecules: cholesterol and cholestanol. These become deposited in the central nervous system causing dementia, psychiatric disturbances, epilepsy, cerebellar syndromes, peripheral neuropathy and ...
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Health survey of adults with hereditary spastic paraparesis compared to population study controls
... hereditary spastic paraparesis (HSP) is used to describe a group of neurodegenerative conditions with a high degree of clinical and genetic heterogeneity ...progressive spastic weakness in the lower ...
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Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation
... The most noteworthy clinical features in the present case were the young age at onset and very long dis- ease duration. It was reported that the mean age at onset in 564 patients with PSEN1-linked AD was 43.3 ± 8.6 ...
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In vivo expression of the HBZ gene of HTLV 1 correlates with proviral load, inflammatory markers and disease severity in HTLV 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
... Human T-cell lymphotropic virus type 1 (HTLV-1) is a replication-competent human retrovirus [1,2] which is associated with adult T-cell leukemia (ATL) [3,4] and with a slowly progressive neurological disorder ...
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AYURVEDA: A HOPE FOR HSP- HEREDITARY SPASTIC PARAPARESIS .......
... Hereditary spastic paraparesis (HSP) is not a single disease entity; it is a group of clinically and genetically diverse ...progressive spastic weakness beginning in the distal lower extremities i ...
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Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial
... Human T lymphotropic virus type I (HTLV-I) infects approximately 10 to 20 million people worldwide, mainly in large endemic areas such as southern Japan, the Caribbean, Central and South America, the Middle East, ...
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Polygenic control of human T lymphotropic virus type I (HTLV-I) provirus load and the risk of HTLV-I-associated myelopathy/tropical spastic paraparesis
... Human T lymphotropic virus type I (HTLV-I), a member of the Oncovirus family, is the etiological agent of 2 diverse dis- eases: the neurological disorder HTLV-I–associated myelopa- thy/tropical spastic ...
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