Sphingolipid metabolism
Resveratrol and its oligomers : modulation of sphingolipid metabolism and signaling in disease
... modulate sphingolipid metabolism and increases pro-apoptotic ceramide levels, future studies should explore whether this effect is cell-type ...and sphingolipid metabolism appear concentration ...
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Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration
... in sphingolipid content in the brain following haloperidol ...the sphingolipid metabolism pathway in the recent diagnosis cohort but not the chronic disease cohort, with further real-time PCR ...
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Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift
... As such, published microarray data contain a hidden wealth of information, and often specific aspects of cell regulation are of interest to particular investigators. There- fore, there are increasing needs to develop ...
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Drosophila DNA/RNA methyltransferase contributes to robust host defense in aging animals by regulating sphingolipid metabolism
... Drosophila sphingolipid metabolic pathways). In sphingolipid metabolism, levels of storage metabolites such as S1P, ceramides and TAG have to be maintained in a dynamic manner for cellular ...of ...
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Altering Sphingolipid Metabolism in Saccharomyces cerevisiae Cells Lacking the Amphiphysin Ortholog Rvs161 Reinitiates Sugar Transporter Endocytosis
... Altering sphingolipid levels in rvs161 cells remediates this defect, but how lipid changes suppress remains to be ...of sphingolipid metabolism suppresses these ...Altering sphingolipid ...
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Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice
... The expression levels of enzymes involved in sphingolipid metabolism during pregnancy. Relative mRNA expression of Sphk1, Sphk2, Sptlc1, Sptlc2, Sgpl1, Sgpp1, Smpd1, Smpd2, Smpd3, Asah1, Asah2, Lass1, ...
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TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism
... It is well known that muscle atrophy results from both decreased protein synthesis and accelerated proteolysis. In agreement with a pro-atrophic role of TNF-a, we found that the cytokine lowered protein synthesis and ...
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DEGS1 associated aberrant sphingolipid metabolism impairs nervous system function in humans
... as sphingosine-1-phosphate (S1P) and ceramide-1-phosphate are bioactive lipid hormones that regulate a variety of physiological functions. Ceramides are central components of SL metabolism, as they form the ...
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Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case–control study
... In sum, on the basis of the predicted metagenome in this case–control study, we found significant differ- ences in the functional potential of fecal microbiome between infants with bronchiolitis and healthy con- trols. ...
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The Composition of West Nile Virus Lipid Envelope Unveils a Role of Sphingolipid Metabolism in Flavivirus Biogenesis
... lipid metabolism by different viruses has recently been documented ...lipid metabolism have been ob- served in dengue virus (DENV)-infected cells (26, 27), and several studies have highlighted the ...
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SPHINGOMYELIN METABOLITES A S SECOND MESSENGERS IN AIRWAY SMOOTH MUSCL E CELL P ROLIFERATION
... activate sphingolipid metabolism, airway smooth muscle cells were labeled with [3H] palmitate for 48 h to allow equilibrium labeling of sphingolipid pools prior to ...
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Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy
... DhCer may be toxic for myelinating oligodendrocytes or for the biogenesis of the myelin sheath. By the same token, and beyond the plausible direct negative effects of substrate accumulation in this case, we should ...
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Airway reactivity and sphingolipids—implications for childhood asthma
... of sphingolipid metabolism is complex, incompletely understood, and involves a network of multiple interconnected mechanisms [6, ...vage sphingolipid synthesis pathways [22] and indicating that ...
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Sphingolipid and ceramide homeostasis : potential therapeutic targets
... so sphingolipid biosyn- thesis, by myriocin, suppresses hepatitis C virus replication ...host sphingolipid metabolism may provide a new combined therapeutic strategy for treatment of both protozoal ...
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Berchtold, Doris (2012): TOR complex 2 regulates plasma membrane homeostasis. Dissertation, LMU München: Fakultät für Biologie
... to sphingolipid metabolism (Tabuchi et ...complex sphingolipid levels in the plasma ...complex sphingolipid levels in the plasma membrane and thereupon activates its downstream effectors, Ypk ...
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Role of sphingolipids in senescence: implication in aging and age related diseases
... In vitro studies suggest that the p53’s tumor-suppressive effects could be mediated, at least in part, through the downreg- ulation of SK1, leading to decreased S1P levels and increased Cer and Sph levels, which then ...
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Comparative Immune-Related Metabonomics Analysis of Plasma from Mouse after Given Long-Term Astragalus Membranaceus and Panax Ginseng
... Glycerophospholipid metabolism was found in both AM and PG groups. Pyrimidine metabolism and sphingolipid metabolism were closely regulated in AM ...Energy metabolism (starch and ...
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Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells
... normalized sphingolipid metabolism in the liver of old rats [11] with an extremely low, as compared to young animals, level of hepatocellu- lar glutathione ...on sphingolipid turnover have been ...
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Epigallocatechin-3-gallate inhibits paclitaxel-induced apoptosis through the alteration of microRNA expression in human dermal papilla cells
... phosphate metabolism, and sphingolipid metabolism in paclitaxel-treated HDP cells, and EGCG-downregulated miRNAs regulated Fc gamma R-mediated phagocytosis, pathways in cancer, MAPK signaling ...
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Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1
... reduce sphingolipid synthesis and generate catalytic promiscuity, incorporating alanine or glycine into the precursor sphingolipid to generate a deoxysphingoid base ...
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