sphingosine-1-phosphate
Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells
... atherosclerosis. Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid released from activated platelets, exerts a variety of responses such as cell migration and proliferation, and reportedly ...
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Genetic elevation of Sphingosine 1 phosphate suppresses dystrophic muscle phenotypes in Drosophila
... lipid phosphate phosphatase 3, which in higher animals can dephosphorylate a range of ...lipid Sphingosine 1- phosphate (S1P), which promotes cell proliferation and differentiation in many ...
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Sphingosine kinase 1 and sphingosine 1 phosphate receptor 2 are vital to recovery from anaphylactic shock in mice
... kinase 1 (SphK1) and SphK2 are ubiquitous enzymes that generate sphingosine-1-phosphate (S1P), a ligand for a family of G protein–coupled receptors (S1PR1–S1PR5) with important functions in ...
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Elevated sphingosine 1 phosphate promotes sickling and sickle cell disease progression
... Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates multicellular functions through inter- actions with its receptors on cell surfaces. S1P is enriched and stored in erythrocytes; ...
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Roles of sphingosine-1-phosphate signaling in cancer
... S1P: sphingosine-1-phosphate; SphKs: sphingosine kinases; ABCC1: ATP- binding cassette C1; ABCG2: ATP-binding cassette G2; Spns2: spinster 2; S1PRs: S1P receptors; Gq, Gi, and G12/13: G ...
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Mutations in sphingosine 1 phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
... in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of ...encodes sphingosine-1-phosphate (S1P) ...
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Role of Sphingosine 1 Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —I
... of sphingosine 1-phosphate (S1P)-S1P receptor 1 (S1P1) axis in lymphocytes for EAE development when C57BL/6 mice were immu- nized with myelin oliogodendrocyte glycoprotein ...
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Erythrocyte derived sphingosine 1 phosphate is essential for vascular development
... mediator sphingosine 1-phosphate (S1P) to the systemic circulation is an essential function of rbc in ...of sphingosine kinases 1 and 2 (Sphk1 and Sphk2) showed embryonic lethality ...
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Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation
... Sphingosine 1-phosphate (S1P) is a bioactive lipid that is physiologically present in serum and capable of regulat- ing multiple essential cellular processes, including cell growth and survival, cell ...
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Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
... increased sphingosine kinase 1(SPHK1) mRNA and also with decreased sphingosine-1-phosphate lysase 1(SGPL1) ...cellular sphingosine-1-phosphate (S1P), and S1P ...
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Sphingosine 1-phosphate receptor 1 signaling in mammalian cells
... lipid, sphingosine 1-phosphate (S1P), is produced by phosphorylation of sphingosine, catalysed by two isoforms of sphingosine kinase (SK1 and SK2), whereas its degradation involves ...
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Emerging biology of sphingosine 1 phosphate: its role in pathogenesis and therapy
... Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive lipid mediator that regulates many processes in vertebrate development, physiology, and pathology. Once exported ...
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Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration
... Sphingosine 1-phosphate (Sph-1-P) plays important roles as an extracellular mediator through its interactions with the G protein-coupled receptor S1P1-5, which is expressed on the cell ...
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Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency
... Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant ...
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Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy
... A hallmark of several major neurological diseases is neuronal cell death. In addition to this primary pathology, secondary injury is seen in connected brain regions in which neurons not directly affected by the disease ...
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Effects of sphingosine-1-phosphate receptor 1 phosphorylation in response to FTY720 during neuroinflammation
... messenger sphingosine-1-phosphate (S1P) pathway is a major immune regu- latory pathway in MS pathogenesis ...(S1PRs) 1 and 3–5, is an exciting advance in MS therapy because FTY720 treatment ...
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Expression and Role of Sphingosine 1-Phosphate Receptors in Intervertebral Disc Degeneration
... it. Sphingosine 1-phosphate (S1P) is an important lipid mediator, has been confirmed to be implicated in many inflammation ...type 1 motif 4(ADAMTS4) induced by ...
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Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation
... phosphatase 1; SK, sphingosine kinase; S1P, sphingosine 1- phosphate; S1P 1 , sphingosine 1-phosphate receptor-1; TH, T helper ...
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Galactosylsphingosine (psychosine) induced demyelination is attenuated by sphingosine 1 phosphate signalling
... The GALC enzyme, mutated in Krabbe disease, is involved in the complex pathway of sphingolipid metabolism, which includes bioactive lipids such as ceramide, sphingosine and sphingosine ...
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Sphingosine 1 phosphate signalling
... Sphingolipids are crucial for membrane structure and function in eukaryotes. Their metabolism leads to the formation of polar lipid mediators such as sphingosine 1-phosphate (S1P) (Saba and Hla, ...
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