Spike protein
SARS-CoV19-2 spike protein mutation patterns: a global scenario
... /https://coronavirus.jhu.edu/data/mortality), this could be due to change in geographical region physical factors, ethnicity, different genetic determinants and phenome of local population, food habit and relative herd ...
14
Mutation hot spots in Spike protein of COVID-19
... Spike protein of Coronaviruses help in receptor binding and virus entry into the host ...While spike protein helps in receptor mediated virus entry, it is also extremely important as an ...
10
Identification of NCAM that interacts with the PHE CoV spike protein
... PHE-CoV spike protein will facilitate the description of the binding domain of the spike protein, which will pre- sumably be the most effective target epitope for a spike ...
11
Drug and Vaccine Design against Novel Coronavirus (2019-nCoV) Spike Protein through Computational Approach
... The spike protein showed no significant matches with human protein by blast ...of spike protein through blastp search against viral genome showed Severe acute respiratory ...
16
Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2
... Saliva proteins are known to contain virus-binding proteins and be involved in viral pathogenesis. Many viruses bind to saliva through recognizing glycan ligands attached to host mucins [8-12]. Sialic acid-containing ...
15
Immunological Characterization of the Spike Protein of the Severe Acute Respiratory Syndrome Coronavirus
... capsid, spike, membrane, and small envelope ...of spike protein were generated, the first were approximately 210-bp nonoverlapping fragments and the second were overlapping segments of 750 to 900 ...
7
Analysis of the receptor-binding site of murine coronavirus spike protein.
... It has been found that a domain composed of 330 amino acids of the N terminus of murine coronavirus spike protein [S1N(330)] is involved in receptor-binding activity (H. Kubo, Y. K. Yamada, and F. Taguchi, ...
5
Epigallocatechin-gallate and Theaflavin-gallate interaction in SARS CoV-2 spike-protein central-channel with reference to the hydroxychloroquine interaction: Bioinformatics and Molecular Docking Study.
... The spike- glycoproteins of the COVID-19 (similar to SARS-CoV) attach to the angiotensin-converting-enzyme (ACE-2) and transit over a stabilized open-state for the viral-internalization to the host-cells and ...
11
S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus is an Important Determinant of Virulence in Piglets
... which is the source of S and S1 fragments inserted into chimeric PEDVs, showed severe clinical signs such as dehydration, weight loss, acute viral shedding in feces and sera from 1–2 DPI, and high virus titers in small ...
18
The Severe Acute Respiratory Syndrome (SARS) coronavirus 3a protein may function as a modulator of the trafficking properties of the spike protein
... It therefore appears that the cell surface expression of S protein of SARS-CoV can be reduced like that for other coronaviruses, but the mechanism may be different. The trafficking of SARS-CoV S may be mediated ...
5
Role of spike protein conformational changes in fusion of Semliki Forest virus.
... RESULTS In all of the experiments performed to determine the kinetics of SFV fusion or spike protein conformational changes, virus was bound to the plasma membrane of BHK cells and acid [r] ...
11
The Viral Spike Protein Is Not Involved in the Polarized Sorting of Coronaviruses in Epithelial Cells
... preferentially released from basolateral and apical membranes, respectively. (iii) We recently demonstrated that coronavirus-like particles resembling normal virions were assembled and released when the envelope pro- ...
7
Interactions of Rotavirus VP4 Spike Protein with the Endosomal Protein Rab5 and the Prenylated Rab Acceptor PRA1
... Rotavirus spike protein VP4 is implicated in several important functions, such as cell attachment, penetra- tion, hemagglutination, neutralization, virulence, and host ...Rab5 protein or the ...
7
An insilico study to identify hidden features of Spike protein and Main protease of SARS-Cov2
... The protein structures of the spike protein (S) and the main protease (Mpro) were analysed computationally using the tools castp (Tian, et ...The protein structures of S and Mpro were ...
11
S1 domain of the porcine epidemic diarrhea virus spike protein as a vaccine antigen
... 1B, spike (S), ORF3, envelope (E), membrane (M) and nucleocapsid ...S protein is present at the outer surface of the virion and is 1386 amino acid long ...The spike protein of coronaviruses ...
10
Assembly of coronavirus spike protein into trimers and its role in epitope expression.
... 4c, the following conclusions were reached: i S apoprotein formed heterogeneous aggregates in the presence of tunicamycin, as indicated by spreading of immunoreactive material thoughout [r] ...
9
Receptor-Induced Conformational Changes of Murine Coronavirus Spike Protein
... surface protein conformational changes, as revealed by proteinase resistance or antigenic changes (17, 39, 40, ...the protein from a fusion-negative form to a fusion-positive form, which mediates viral ...
8
The Spike Protein of Infectious Bronchitis Virus Is Retained Intracellularly by a Tyrosine Motif
... S protein of IBV, a group 3 coronavirus, is not transported to the cell surface but is retained at an intracellular compartment ...parental protein. Therefore, the retention signal in the IBV S ...
7
Spike protein oligomerization control of Semliki Forest virus fusion.
... 5214 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have recently shown, using cleavage-deficient mutants of the p62-El membrane protein complex of Semliki Forest v[r] ...
5
Mutagenesis of the putative fusion domain of the Semliki Forest virus spike protein.
... The expressed spike proteins showed efficient cleavage of the p62 precursor, cell surface localization of both the E2 and El subunits, and membrane fusion activity with a pH dependence s[r] ...
9