Spindle assembly checkpoint proteins
Mlp1 Acts as a Mitotic Scaffold to Spatially Regulate Spindle Assembly Checkpoint Proteins in Aspergillus nidulans
... GFP-tagged proteins together with An-Nup49-mCherry as a marker for partial disassembly and reassembly of ...the spindle pole bodies (SPBs) during G2 in ...prophase spindle formation (Figure 3B, ...
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Specific Genetic Interactions Between Spindle Assembly Checkpoint Proteins and B-Type Cyclins in Saccharomyces cerevisiae
... in spindle elongation and cytokinesis: A conditional mutant was generated to further study the lethality in the bub3 clb5 double ...the spindle and septin ring in the cells, we employed Tub1 tagged with ...
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... nocodazole-arrest, despite the small reduction in mitotic arrest when treating prior to mitotic entry (Fig. 1). These data are consistent with previous reports that Aurora B inhibition delays, not prevents, initial MPS1 ...
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... First, we confirmed the effect of NDGA on the localisation of MAD1; NDGA treatment caused dynein-bound MAD1 to strongly accumulated at the centrosome (Fig. 3A), indicating inhibition of MAD1 release from dynein, ...
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Diverse Functions of Spindle Assembly Checkpoint Genes in Saccharomyces cerevisiae
... chore proteins (cbf1, chl4, ctf3, mcm16, mcm19, mcm21, mcm22, sli15, and slk19), and although the precise roles of each of these kinetochore proteins are unknown, it seems probable that at least one of them ...
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Fanconi anemia signaling network regulates the spindle assembly checkpoint
... FA proteins are essential for interphase DNA damage repair; however, it is incompletely understood why FA-deficient cells also develop gross aneuploidy, leading to ...FA proteins in chromosome segregation ...
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Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
... The spindle assembly checkpoint The spindle assembly checkpoint is a complex signal transduction cascade that inhibits the metaphase to ana- phase transition in the presence of ...
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Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer
... motor proteins CENPE and CENPF are required for proper microtubule attachment and regula- tion of the spindle checkpoint [23, ...with spindle microtubules is believed to modulate mitotic ...
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Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer.
... motor proteins CENPE and CENPF are required for proper microtubule attachment and regula- tion of the spindle checkpoint [ 23 , 28 ...with spindle microtubules is believed to modulate mitotic ...
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Synthetic Lethal Interactions Identify Phenotypic “Interologs” of the Spindle Assembly Checkpoint Components
... both proteins resulted in highly penetrant embryonic lethality, chromosome segregation defects, inability to form metaphase plates, and precocious anaphase onset, as previously reported (M oore et ...the ...
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The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond
... classical spindle checkpoint proteins, the chromosomal passenger complex was not absolutely required to signal the pres- ence of unattached kinetochores, but only the presence of incorrectly attached ...
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5 The abbreviations used are: SAC, spindle assembly checkpoint; APC/C, anaphase-promoting
... cycle proteins and their ...and spindle assembly checkpoint maintain genomic integrity by delaying cell cycle progression in the pres- ence of DNA or spindle damage, ...SAC ...
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APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment
... the Spindle Assembly Checkpoint (SAC) that monitors kinetochore attachment to the mitotic ...mitotic checkpoint proteins complexes (MCCs) that bind and inhibit the Anaphase Promoting ...
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Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes
... to checkpoint impairment and chromosome ...nuclear proteins High Mobility Group A1 (HMGA1), whose overexpression is a feature of several human malignancies and has a key role in cancer progression, as ...
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An α-Tubulin Mutant Demonstrates Distinguishable Functions Among the Spindle Assembly Checkpoint Genes in Saccharomyces cerevisiae
... the spindle assembly bind to microtubules in mitosis and help generate the checkpoint that binds to and is phosphorylated by Bub1p force required to separate sister chromatids during ana- (Hoyt et ...
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Premature Silencing of the Spindle Assembly Checkpoint Is Prevented by the Bub1-H2A-Sgo1-PP2A Axis in Saccharomyces cerevisiae
... 2014), another untested possibility is that Sgo1 regulates SAC silencing through condensin; but recent work supports the pos- sibility that the condensin facilitates chromosome biorientation (Verzijlbergen et al. 2014). ...
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Epstein-Barr Virus-Induced Resistance to Drugs That Activate the Mitotic Spindle Assembly Checkpoint in Burkitt's Lymphoma Cells
... EBNA-LP is truncated in the P3HR1-converted cells and is expressed at a very low level in the nocodazole-resistant Oku-BL cells, arguing against EBNA-LP playing a significant role (14). BL cells with a latency I pattern ...
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Drosophila Mis12 Complex Acts as a Single Functional Unit Essential for Anaphase Chromosome Movement and a Robust Spindle Assembly Checkpoint
... kinetochore proteins fused to EGFP were generated by standard P-element–mediated germ line transformation and by selection on the basis of the use of the mini-white dominant marker ...fusion proteins in the ...
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Two Complexes of Spindle Checkpoint Proteins Containing Cdc20 and Mad2 Assemble during Mitosis Independently of the Kinetochore in Saccharomyces cerevisiae
... initiates spindle checkpoint ...the spindle checkpoint? More complex models that require the kinetochore as the site of assembly can be ...
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Li, He (2017): APC/C independent function of the spindle assembly checkpoint. Dissertation, LMU München: Fakultät für Biologie
... Therefore, we sought to use other methods to confirm our results. APC/C Cdh1 is active when Cdk1 activity is low. Therefore, although APC/C Cdh1 is not the primary target of the SAC, it is possible that APC/C Cdch1 ...
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