Spontaneously Hypertensive Rat
Renal prostaglandin synthesis in the spontaneously hypertensive rat
... a spontaneously hypertensive rat ...and rat there is a steep gradient of microsomal prostaglandin synthetase from papilla to cortex with highest activities in the ...and hypertensive ...
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Blood pressure development of the spontaneously hypertensive rat after concurrent manipulations of dietary Ca2+ and Na+ Relation to intestinal Ca2+ fluxes
... The blood pressure of the spontaneously hypertensive rat (SHR) is influenced by the Ca2+ content of its diet. As the SHR's greater dependence on dietary calcium may reflect a defect in intestinal ...
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Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat
... in spontaneously hypertensive rat strain (SHR hereafter; Rat Genome Database (RGD) [8] ID: 631848) leads to microphthalmia and cataract ...
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Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains
... stroke-prone spontaneously hypertensive rat (SHRSP) develops severe hypertension and, as opposed to its related control strain, the stroke-resistant SHR, shows an increased occurrence of ...
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In vivo assessment of arterial stiffness in the isoflurane anesthetized spontaneously hypertensive rat
... The spontaneously hypertensive rat is a well-characterized model of arterial hypertension that closely mirrors many of the features observed in hypertensive patients and has been used to ...
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Defective dopamine 1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat
... The natriuretic effect of DA-1 agonists is less in the spontaneously hypertensive rat (SHR) than its normotensive control, the Wistar-Kyoto rat (WKY). To determine a mechanism of the decreased ...
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Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange
... The cellular mechanisms responsible for abnormalities in spontaneously hypertensive rat (SHR) vascular smooth muscle cell (VSMC) growth and vasoreactivity are not defined. Because Na+/H+ exchange, ...
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Role of the Renal Sympathetic Nerves in the Development and Maintenance of Hypertension in the Spontaneously Hypertensive Rat
... the spontaneously hypertensive rat of the Okamoto ...(early hypertensive) and 18-wk-old (established hypertensive) male spontaneously hypertensive rats were subjected to ...
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Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat
... The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. De- spite . 30 yr of research, the primary genetic lesions re- sponsible for hypertension ...
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A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure
... the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive ...
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Abnormal vitamin D metabolism, intestinal calcium transport, and bone calcium status in the spontaneously hypertensive rat compared with its genetic control
... Abnormalities of intestinal calcium absorption and the vitamin D axis in the spontaneously hypertensive rat (SHR) are controversial. The present report documents a reduction in circulating ...
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4-20-2011 12:00 AM On the early onset of vascular stiffening and sexual dimorphism of sympathetic control in the spontaneously hypertensive rat
... the spontaneously hypertensive rat (SHR) has identified many underlying pathologies that lead to the development of HT, including alterations in the Renin-Angiotensin System, renal physiology and the ...
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Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat
... the spontaneously hyperten- sive rat and normotensive Brown-Norway ...(BN.Lx) rat fed normal and high cholesterol ...of spontaneously hypertensive rat indicated that QTLs ...
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Kinetic properties of the Na+/H+ antiporter of lymphocytes from the spontaneously hypertensive rat: role of intracellular pH
... from hypertensive subjects but the intracellular pH (ipH) dependency of its activity has not been ...adult spontaneously hypertensive rats (SHR) and in those from age-matched normotensive ...
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Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid
... in hypertensive tissues therefore are probably the result of the detri- mental effects of superoxide anions and other free radicals on EDNO and not the result of EDNO-prostanoid ...in hypertensive tissues ...
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Instrumental conditioning for food reinforcement in the spontaneously hypertensive rat model of attention deficit hyperactivity disorder
... The spontaneously hyperten- sive rat (SHR) is one suggested animal model of ADHD, considered to best model ADHD-C [18], but it is gener- ally accepted to exhibit good ...
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Behavioural effects of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis protocol
... Introduction Attention-deficit/hyperactivity disorder (ADHD) is a prevalent condition related to several negative outcomes, and its pathophysiology is still poorly understood. The spontaneously hypertensive ...
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Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure
... In the study in Dahl rats in which an RFLP in the renin gene cosegregated with increased blood pressure 15, it appeared that two doses of the Dahl S renin allele conferred a greater incr[r] ...
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Calcium and sodium transport and vitamin D metabolism in the spontaneously hypertensive rat
... the spontaneously hypertensive (SH) rat than in the normotensive Wistar- Kyoto (WKy) ...SH rat is ...SH rat was decreased (P less than ...
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Enrichment Discrimination Behavior in Spontaneously Hypertensive Rats
... among spontaneously hypertensive rats, subpopulations that diverge in attention to objects enriching an empty cross-maze; 2) To evaluate effect of clinically efficient drug for treatment of attention ...
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