SQSTM1/p62
Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming
... on SQSTM1/p62 ...reduced SQSTM1/p62 levels in LP-1/Cfz cells (Figure 8A) and sensitized LP-1/Cfz cells to carfilzomib (Figure 8B, top ...decreased SQSTM1/p62 levels (Figure 8C, ...
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KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models
... by SQSTM1/p62 ...with SQSTM1/p62, augmenting association with LC3B‑II and facilitating autophagic degradation of aggresomes, in response to various types of cellular stress including ...
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Prognostic value of the autophagy markers LC3 and p62/ SQSTM1 in early-stage non-small cell lung cancer
... and p62/SQSTM1 (p62) are associated with autophagosomal membranes that engulf cytoplasmic content for subsequent ...and p62 expression using immunohistochemistry in a large cohort of 466 stage ...
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Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model
... in SQSTM1 are linked to ALS. SQSTM1 encodes SQSTM1/p62 that regulates not only autophagy via the association with MAP1LC3/LC3 and ubiquitinated proteins but also the KEAP1-NFE2L2/Nrf2 ...
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Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis
... the p62/SQSTM1 gene and protein in AML12 mouse liver ...reported p62/SQSTM1 as a key molecule for antioxidation and cell survival in hepatocytes, we next examined the activation of nuclear ...
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The Role of p62/SQSTM1 in TGFβ-dependent EMT and Autophagy
... that p62/SQSTM1 co-localizes with TGFβ receptors at the same time point that the receptors localize to Rab7-positive late ...of p62/SQSTM1 was also observed to prime non-small cell lung cancer ...
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Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family
... except one patient with a single X-ray-assessed skeletal localization and one with a polyostotic disease who had died several years before the DNA analysis. By both reconstitution and mutational analysis of the pedigree, ...
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AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
... In this study, we investigate the molecular mechanism(s) responsible for the AMBRA1-dependent enhancement of PARKIN-mediated mitophagy. We describe for the first time AMBRA1 as a new LIR (LC3 interacting ...
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SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells
... Additional file 1: Figure S1. C-2 significantly induced apoptosis in hu- man bladder cancer cells. (A) A dose-dependent induction of apoptosis by C-2 was demonstrated through flow cytometric analysis of Annexin V/ PI ...
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Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia
... 14]. SQSTM1 can also interact with many other signaling molecules such as TRAF-6 (TNF receptor-associated factor 6) [15, 16] and Raptor [17, 18], leading to the activation of NFκB and mTORC1 (mammalian target of ...
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Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1
... (SQSTM1; p62). SQSTM1 levels were elevated in LTC, a conse- quence of protein accumulation due to decreased autophagy and Nrf2-mediated transcriptional ...activation. SQSTM1 was phosphorylated ...
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mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy
... Inc.); SQSTM1/p62 (GP62-C; Progen); mTOR (2983; Cell Sig- naling Technology); LC3 (NB100-2220; Novus Biologicals); WIPI-2 (ab105459; Abcam); c-Myc (sc-40; Santa Cruz Biotechnology ...
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Association of a structural variant within the SQSTM1 gene with amyotrophic lateral sclerosis
... of SQSTM1 variants to the fALS. SQSTM1-encoded p62 protein is a key scaffolder involved in cellular signaling and protein deg- radation through the autophagosome-lysosome ...17 ...
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Mining the TRAF6/p62 interactome for a selective ubiquitination motif
... A new approach is described here to predict ubiquitinated substrates of the E3 ubiquitin ligase, TRAF6, which takes into account its interaction with the scaffold protein SQSTM1/p62. A novel TRAF6 ...
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Epithelioid cell histiocytoma with SQSTM1-ALK fusion: a case report
... The SQSTM1 gene encodes sequestosome-1 (also known as the ubiquitin-binding protein p62), which acts as a cargo protein in selective ...ECH, SQSTM1-ALK has also been reported in some cases of ...
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Original Article Beclin 1 and p62 expression in non-small cell lung cancer: relation with malignant behaviors and clinical outcome
... protein p62/sequestosome 1 ...and p62 in the three NSCLC cell ...with p62, in accordance with the previous studies about their roles in autophagy regulation ...substrate, p62 accumulation is a ...
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The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection
... Autophagy is a fundamental cellular pathway in eukaryotes that functions to maintain homeo- stasis by degradation of cytoplasmic contents in lysosomes [1]. During autophagy, protein aggregates or defective organelles are ...
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miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo
... or SQSTM1) is an ubiquitin-binding protein that chaperones protein aggregates to the lysosome for degradation during autophagy, and is up-regulated by autophagy inhibition [4, 32, ...[34]. p62 binds to the ...
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C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis
... CO), p62/SQSTM1 (H00008878, Novus Biologicals), cathepsin D (sc-10725, Santa Cruz), Lysosomal-associated membrane protein (LAMP2) (NBP1-71692, Novus Biologicals), Rubicon (8465, Cell Signaling Technology, ...
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Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
... tumors [112–114]. It has been recently identified, for example, that the novel therapeutic strategy targeting autophagy in GBM focuses not only on conventional drugs but also on endogenous neurotransmitters in the ...
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