Src family
Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport
... these Src-family tyrosine kinases does not seem to be species restricted since Lyn, Hck, and Fgr are also found in human red cells (21 and ...that Src- family kinases participate in cell ...
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Diverse Requirements for Src Family Tyrosine Kinases Distinguish Chlamydial Species
... a Src-family kinase inhibitor led to a decrease in ...the Src-family kinase ap- pear to be acting though pathways other than mouse-specific ...to Src-family kinase ...
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Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
... unprecedented: Src-family kinases have SH3 domains which can bind to tau [40-42], and Src-SH3 and Fyn-SH3 show some distinct differences in binding to various forms of tau that are hard to explain ...
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The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles
... In the current study, we have observed that the src family kinase c-Yes is upregulated during WNV infection and that inhibition of SFK activity reduces the production of infectious virus. The role of c-Yes ...
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Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction
... HeLa T-REx FRT cells expressing STAT5A-eYFP or STAT5A R618Q -eYFP were lysed with storage buffer (150 mM NaCl, 50 mM Tris–HCl, pH 7.5, 0.1 mM EDTA, 10% glycerol, 0.5% Nonidet P-40) supplemented with phosphatase/protease ...
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The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases
... Increased airway smooth muscle (ASM) contractility and the development of airway hyperresponsiveness (AHR) are cardinal features of asthma, but the signaling pathways that promote these changes are poorly understood. ...
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Lipid Raft- and Src Family Kinase-Dependent Entry of Coxsackievirus B into Human Placental Trophoblasts
... Previous work has demonstrated a significant role for SFK members in mediating various aspects of CVB entry into polarized intestinal epithelial and human brain microvascular endothelial cells (6, 13). Additionally, SFKs ...
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Expression patterns of Src family tyrosine kinases during Xenopus laevis development
... ABSTRACT Src family tyrosine kinases (SFKs) play important roles in cell morphology, differen- tiation, motility and ...of Src kinases are characteristic for several types of human ...genes ...
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SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer
... FYN is a SRC family kinase (SFK) that has been shown to be up-regulated in human prostate cancer (PCa) tissues and cell lines. In this study, we observed that FYN is strongly up-regulated in human ...
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Roles of Src family kinase signaling during fertilization and the first cell cycle in the marine protostome worm Cerebratulus
... For immunoblots, oocytes were probed with phospho-specific anti- bodies (#9101 phospho-ERK 1/2 MAPK, #9114 phospho-T161 Cdc2 MPF, #2101 phospho-Src family kinases from Cell Signaling, Beverly, MA, USA) ...
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The role of Src family kinases in mediating M CSF receptor signaling and monocytic cell survival
... (RTK) family, which includes platelet-derived growth factor (PDGF) receptor, c-Kit and Flt3/Flt2 receptors ...as Src family kinases, PI3-kinase/Akt and Ras/MAPK leading to the induction of a cascade ...
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Palatal adhesion is dependent on Src family kinases and p38MAPK
... kinases, Src family kinases (SFK) are well known to accumulate at both the cell-cell adherence junctions and cell-extracellular matrix adhesions (Huveneers and Danen, 2009, McLachlan et ...including ...
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Regulation of the Src Family Kinases by Csk
... The Src family tyrosine kinases (SFKs) are the major non-receptor tyrosine kinases expressed in multiple types of animal cells [3]. The SFKs include eight members, c-Src, c-Yes, Fyn, c-Fgr, Lyn, Hck, ...
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State and Role of Src Family Kinases in Replication of Herpes Simplex Virus 1
... members Src, NSrc, Fyn, Yes, and Fgr were PCR amplified from the relevant cDNA clones and fused in frame with ...included Src, Fyn, Yes, and Fgr, pulled down ...neuronal Src, which contains a ...
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Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells
... and Src-1, two other small molecule SFK inhibitors [25,26] were also tested, but found to be much less potent than PP2 in reducing overall pY levels in SW620 cells and did not effectively inhibit Odin tyrosine ...
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An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases.
... A 70-kDa cell protein which was previously detected in immune complex kinase reaction products of LMP2A immunoprecipitates 43 was also detected in BJAB cell extracts immunoprecipitated w[r] ...
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The Cbl family of ubiquitin ligases regulates FcεRI expression and mast cell activation
... FcεRIα-chain contains two extracellular Ig-like do- mains involved in IgE binding, a transmembrane region with an aspartic acid residue and a short cytoplasmic tail that lacks signal transduction motifs. The β and γ sub- ...
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Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM
... the Src family (SFK) is upregulated during development, with roles in neuronal differentiation and axon guidance 1 ...their Src homology 3 (SH3) domains 2,3 ...of Src kinase, firstly via ...
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Oxidative stress activates extracellular signal regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats
... A growing body of evidence has suggested that oxidative stress causes cardiac injuries during ischemia/reperfusion. Extracellular signal-regulated kinases (ERKs) have been reported to play pivotal roles in many aspects ...
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hiPSCs: Reprogramming towards cell based therapies
... pan-Src family kinase (SFK) have also shown that activation of Nanog can replace Sox2 to virally reprogram MEFs [61]; SFk inhibitors have not been adequately assayed in hiPSC reprogramming but have been ...
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