Src family kinase
Herpes Simplex Virus Requires VP11/12 To Activate Src Family Kinase-Phosphoinositide 3-Kinase-Akt Signaling
... Our previous studies raised the possibility that VP11/12 modulates one or more cellular signaling pathways (64, 72). VP11/12 is highly tyrosine phosphorylated in lymphocytes, and in Jurkat T cells, tyrosine ...
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Epstein-Barr Virus Latent Membrane Protein 2A Preferentially Signals through the Src Family Kinase Lyn
... Latent membrane protein 2A (LMP2A) is a viral protein expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. LMP2A has important roles in modulating B-cell receptor ...
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The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus Particles
... The role of cellular genes in West Nile virus (WNV) replication is not well understood. Examination of cellular transcripts upregulated during WNV infection revealed an increase in the expression of the src ...
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SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer
... FYN is a SRC family kinase (SFK) that has been shown to be up-regulated in human prostate cancer (PCa) tissues and cell lines. In this study, we observed that FYN is strongly up-regulated in human ...
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Lipid Raft- and Src Family Kinase-Dependent Entry of Coxsackievirus B into Human Placental Trophoblasts
... pan-tyrosine kinase inhibitor genistein (⬎60%), the SFK inhibitor PP2 ( ⬃ 70%), the microtubule-depolymerizing agent nocodazole (⬎65%), and the myosin II inhibitor blebbista- tin ( ⬎ 85%) all inhibited infection ...
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Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor negative breast cancer via Src family kinase mediated, janus kinase 2 independent pathway
... lipid kinase SK1 was shown to be overexpressed in human breast tumours and linked with poor prognosis, yet the mechanism of its upregula- tion in breast cancer was not ...
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Roles of Src family kinase signaling during fertilization and the first cell cycle in the marine protostome worm Cerebratulus
... ABSTRACT For eggs to generate a calcium response during fertilization, the sperm of many deuterostome animals must first activate a group of egg kinases, called Src family kinases (SFKs). However, whether ...
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SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation
... phospho-SRC family (Tyr416) (this antibody detects SRC only when phosphorylated at Tyr416, which corresponds to human ...sites), SRC, FYN, LCK, LYN, YES, phospho-p38 MAPK (Thr180/Tyr182), p38 ...
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Downregulation of Src Family Kinase Activity Using PP2 Inhibitor Has No Effect on the Elongation of Pragmin-Transfected Adenocarcinoma AGS cells
... of Src tyrosine kinase activity by using PP2 had no effect on the number of Pragmin-transfected AGS cells with elongated ...other Src activity- independent mechanism(s) to be involved in the ...
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Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells
... SFK family expressed in CRC cells due to high conserva- tion of the target epitope (for further details see ...multiple family mem- bers in total cell lysates, or to specifically investigate Lck ...
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hiPSCs: Reprogramming towards cell based therapies
... pan-Src family kinase (SFK) have also shown that activation of Nanog can replace Sox2 to virally reprogram MEFs [61]; SFk inhibitors have not been adequately assayed in hiPSC reprogramming but have ...
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Src kinase inhibition promotes the chondrocyte phenotype
... the Src family kinase inhibitor PP2 (Calbiochem; VWR, Mis- sissauga, Ontario, Canada) or with dimethyl sulphoxide (DMSO; Sigma), the vehicle in which PP2 was dissolved, as ...
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The roles of microRNAs in regulation of mammalian spermatogenesis
... tyrosine kinase [55] and requires a ligand-specific co-receptor GFRα1 [56] in mouse SSCs ...the SRC family kinase (SFK) pathway [59], GDNF regulates the expression of the transcription factors ...
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SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells
... adhesion kinase; FDA: USA Food and Drug Administration; p120ctn: p120 catenin; SRC: Src family kinase ...of SRC, with a concomitant delocalization of p120ctn to the cytoplasm, ...
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Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM
... the kinase assay used to validate the efect of potential SH3 domain ligands on the phosphorylation of an ideal tyrosine motif (Y in bold) located upstream of a 10 aa linker and 12 aa phage ...
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Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors
... of Src kinase was determined using HTScan Src Kinase Assay Kit, catalogue number 7776 from Cell Signaling Technology (Danvers, MA, USA); according to manufacturer's ...the kinase ...
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Nck adapter proteins: functional versatility in T cells
... the Src-activated during mitosis protein (Sam68) indicate distinct roles of Nck in the control of cellular signaling, gene expression and proliferation [1, ...
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Src Is a Potential Therapeutic Target in Endocrine-Resistant Breast Cancer Exhibiting Low Estrogen Receptor-Mediated Transactivation.
... Acquisition of endocrine-resistance is a common occurrence in BC patients and the identification of appropriate clinical interventions remains of paramount importance. Despite multiple drugged targets being proposed from ...
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Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells.
... It is also significant that an inhibitor of tyrosine kinase activity, herbimycin A, can restore a nontransformed phenotype to v-src transformed cells 38 and that alterations in tyrosine [r] ...
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Effects of Src-kinase inhibition in cancer-induced bone pain
... of Src, GluN1, and GluN2B in spinal cord, and that these changes are thought to contribute to the generation and maintenance of ...inhibiting Src, but the precise relationship between S896 phosphorylation ...
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