SRE/SREBP-1
Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c
... GSIS. SREBP-1c is implicated to be involved through regulation of insulin receptor sub- strate 2 (IRS-2), pancreatic duodenal homeobox factor-1 (PDX-1) and uncoupling protein-2 (UCP-2) ...[19]. ...
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GRP78 expression inhibits insulin and ER stress–induced SREBP 1c activation and reduces hepatic steatosis in mice
... and SREBP-1c proteolytic cleavage in cultured rat ...for 1 h with 300 nM thapsigargin or control ...of SREBP-1c in hepatic microsomal membranes and nuclear extracts and immunoblot of GRP78 measured ...
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Regulation of lipogenesis by cyclin dependent kinase 8–mediated control of SREBP 1
... endogenous SREBP target genes, such as FAS, ACC, ATP-citrate lyase (ACLY), and stea- royl CoA desaturase (SCD1), in three hepatocyte lines: primary rat hepatocytes (Figure 3E), FAO cells (data not shown), and ...
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Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells
... the SREBP path- way, which plays a role in ...the SREBP pathway ...of SREBP-1 and the transcription of FAS in breast ...of SREBP-1 in H292 lung cancer cells through two pathways ...
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Down-regulated of SREBP-1 in circulating leukocyte is a risk factor for atherosclerosis: a case control study
... of SREBP-1 mRNA in leukocytes. Transcrip- tionally, SREBP-1 mRNA is strongly induced by insulin via a mechanism involving the liver X receptor (LXR) transcription factors, as well as by ...
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Keratinocyte growth factor and the transcription factors C/EBPα, C/EBPδ, and SREBP 1c regulate fatty acid synthesis in alveolar type II cells
... C/EBPδ, SREBP-1, SREBP-2, SCD-1, SCD-2, and fatty acid synthase by in situ hybridization in our cultures, in normal rat lungs, and in lungs from rats that had been instilled with an adenovirus ...
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Elevated levels of SREBP 2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP 1 gene
... M 1-[2-deoxy-2-fluoro- b - D -arabinofuranosyl]- 5-iodouracil (Bristol-Myers Squibb Pharmaceuticals, Princeton, ...disrupted SREBP-1 allele A, or a primer located in exon 13, 5 9 ...
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p38 Mitogen-Activated Protein Kinase and Liver X Receptor-α Mediate the Leptin Effect on Sterol Regulatory Element Binding Protein-1c Expression in Hepatic Stellate Cells
... and 1 μmol/L insulin) with ...to SREBP-1c promoter and the effect of leptin-induced inhibition of SREBP-1c ex- pression on alpha1(I) collagen transcription in cultured ...to SREBP-1c ...
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SREBP-2, a new target of metformin?
... subtypes, SREBP-1a, SREBP-1c, and SREBP-2. Whereas, SREBP-2 primarily controls cholesterol biosynthesis, and it is initially anchored (precursor protein) in the endoplasmic reticulum and then ...
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AMPK: A POTENT TARGET FOR TREATING OBESITY
... AMPK mediates a number of physiological functions like carbohydrate and lipid metabolism, growth and differentiation, ion transport and blood flow, appetite regulation etc by regulating the genes (shown in ...
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Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP
... of these patients (32). Furthermore, retrospective studies of the effect of lipid lowering by HMG-CoA reductase inhibitors on the incidence of ventricular arrhythmias, as measured by firing of implantable defibrillators ...
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Overexpression of Insig 1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin stimulated lipogenesis
... of SREBP processing to inhibition by dietary ...against SREBP-1 and ...of SREBP-1 and SREBP-2 in lane 1 (WT mice fed with ...
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
... (ADD) 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced dramatically upon fasting and elevated upon ...
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Hypolipidemic activity of Dracocephalum kotschyi involves FOXO1 mediated modulation of PPARγ expression in adipocytes
... PPARγ, SREBP-1 and total FOXO1 in adipose tissue while, the levels of p-AKT and p-FOXO1 (involved in the insulin-signaling pathway) were not influenced among the positive control ...
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Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1
... More information is available about the D9-desaturas- es—fat-5, fat-6, and fat-7—and the elo-2 that responded to SBP-1 in our study. An elo-2 knockdown causes delayed growth and other effects in nematodes [46]; ...
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Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
... Overexpression of dm ChREBP in cultured hepatocytes counteracts the PUFA suppres- sion of L-PK and FAS genes. After plating, hepatocytes were cultured for 24 hours in the presence of 5 mM glucose. Hepatocytes ...
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... of SREBP-1c to 1a transcripts varies markedly among organs of the adult ...the SREBP-1a and 1c transcripts are con- trolled independently by regulatory regions that respond differentially to organ-specific ...
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Isoquercitrin activates the AMP–activated protein kinase (AMPK) signal pathway in rat H4IIE cells
... Total RNA was isolated using Sepasol-RNA I Super G (Nacalai Tesque, Kyoto, Japan). Real-time PCR kits were from TOYOBO (Tokyo, Japan). RNA (1 μg) from each sample was reverse-transcribed to cDNA using the Rever- ...
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Lipid-Modulating Effects of Aqueous Extract of Rubus Occidentalis in Hepatocarcinoma HepG2 Cells
... After incubation with test sample, cells were washed with PBS and lysed in 50 mM Tris-Cl (pH 7.4), 250 mM NaCl, 0.5% Triton X-100, 10% glycerol, 1 mM DTT, 1 mM PMSF and protease inhibitor cocktail (Pierce ...
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The role of Mn and Fe oxides in risk elements retention in soils under different forest types
... Retention of SRE by MnOF and FeOF. The sig- nificance of oxide, FC and horizon as factors was assessed in the framework of the two-factored mixed design ANOVA separately for MnOF and FeOF or separately for hor2 ...
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