Staphylococcus aureus alpha toxin
Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization
... S. aureus, leading to upregulation of ...elevated toxin production, as its activated form binds to both P2 and P3 promoters to drive the agr regulon and decrease repressor of toxin (rot), ...S. ...
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Enzyme linked immunosorbent assay for detection of Staphylococcus aureus alpha toxin
... This paper describes the development of a double-antibody sandwich 35, 36 ELISA for the detection of the alphatoxin of Staphylococcus aureus Wood 46; this form of ELISA overcomes the lim[r] ...
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Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin
... potent toxin produced by most S. aureus isolates and is known to play a key role in ...S. aureus vaccine ...S. aureus-infected mice and human sera toward monomeric and heptameric ...S. ...
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Alpha toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia
... Mouse model of intranasal lung infection. Wild-type C57BL/6J mice (Jackson Laboratory) were bred in the Baylor College of Medicine’s specific pathogen–free barrier facility; all experimental procedures were approved by ...
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Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha Toxin
... S. aureus biofilms secrete a proteinaceous factor(s) that inhibits macrophage ...S. aureus biofilms (4, 15); however, the mechanism responsible for this phenomenon remained to be ...S. aureus ...
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Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency
... human clinical trials (21, 23, 25, 37). These anti-infective MAbs, which are specific for pathogen and not human antigens, are an- ticipated to have relatively few off-target toxicities. In addition, the long serum ...
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Staphylococcus aureus Exotoxins Are Present In Vivo in Tampons
... syndrome toxin 1 (TSST-1) is the cause of menstrual toxic shock syndrome (mTSS) associated with vaginal colonization by Staphylococcus ...and alpha-toxin, another exotoxin, on used tampons ...
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Staphylococcus aureus Induces Eosinophil Cell Death Mediated by alpha-hemolysin
... this toxin is a key cytolytic factor, is controlled by the agr locus and Hla-positive strains are commonly isolated from patients with eosinophillic diseases such as atopic dermatitis ...
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Characterization of Alpha Toxin hla Gene Variants, Alpha Toxin Expression Levels, and Levels of Antibody to Alpha Toxin in Hemodialysis and Postsurgical Patients with Staphylococcus aureus Bacteremia
... of alpha-toxin-expressing S. aureus, IgG, and neutralizing antibody levels against alpha-toxin and the suscepti- bility of different alpha-toxin variants expressed by ...
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Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal Antibody Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease
... S. aureus clinical isolates in the presence of human ...S. aureus strain Newman was incubated with human HL-60 cells, human sera, and serial dilutions of 11H10 or negative-control ...
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Iron Acquisition Mechanisms and Their Role in Staphylococcus aureus Survival and Virulence
... S. aureus secreted both SA and SB (18, ...S. aureus and a staphyloferrin A-‐deficient mutant (sfa), the staphyloferrin B-‐deficient mutant (sbn) was unable to grow by 24 hours in either RPMI ...
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Immunoblots for detection of toxic shock syndrome toxin 1 produced by Staphylococcus aureus
... Colony immunoblot assay for the detection of staphylococcal toxic shock syndrome toxin 1 TSST-1 with anti-TSST-1 Fab'2 fragments.. Rapid screening assay for toxic shock syndrome toxin pr[r] ...
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Staphylococcus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand sequestration
... the toxin complexes are found in re- ceptor clusters indicates that lysis of cells depends on the local density of hC5aRs that will initiate the pore formation process by docking LukS close to the cell membrane, ...
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STUDY OF VANCOMYCIN RESISTANCE AMONG STAPHYLOCOCCUS AUREUS
... research describes this mode of resistance as a tactic in the evolution used by S. aureus strains to allow them to adapt to environments exposed to substances hostile to themselves as vancomycin 35 . However, the ...
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Rapid screening assay for toxic shock syndrome toxin production by Staphylococcus aureus
... A rapid immunoblot assay TST-blot was developed and used to screen Staphylococcus aureus isolates for toxic shock syndrome toxin TST production.. Growth from an 18-h stab inoculum of S.[r] ...
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Antimicrobial activity of some of chlorocobaloximes containing axial substituted pyridines
... as Staphylococcus aureus (MRSA), Salmonella paratyphi-B, Malassezia pachydermatiis, Shigella flexneri MTCC-1457, Candida krusei, Staphylococcus aureus MTCC-96, Staphylococcus ...
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Staphylococcus Aureus Carriage in Selected Communities and Their Antibiotic Susceptibility Patierns
... Staphylococcus Aureus Carriage in Selected Communities and Their Antibiotic Susceptibility Patierns ORIGINAL ARTICLE Staphylococcus Aureus Carriage in Selected Communities and their Antibiotic Suscept[.] ...
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The Prevalence of Methicillin Resistance Staphylococcus aureus Nasal Carriage among Medical Interns in the Academic Charity Teaching Hospital, Khartoum 2016
... S. aureus (n=13, 22%) in the medical lab students out of which 5 were MRSA reservoir, whom are more vulnerable due to their contact to lab equipment and settings, Weinstein et ...
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Serum iron uptake and virulence in Staphylococcus aureus
... S. aureus cell, with increased resources going toward cell wall thickening; this has the effect of saturating ...S. aureus is mediated by the vanA operon, encoding for enzymes that replace terminal D ...
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A Comparative Study of the Antibacterial Activity of Clove and Rosemary Essential Oils on Multidrug Resistant Bacteria
... Clove oil is widely used as a perfume and food flavouring 7 , as a medicine for the treatment of asthma, rheumatoid arthritis, acne, warts, scars and various allergic disorders 8 , as an analgesic, antispasmodic, and as ...
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