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The ATP2C2 Gene as Transcribed from a Novel Transcriptional Start Site in Pancreatic Acinar Cells
... Strict regulation of cytosolic Ca 2+ is essential to regulated exocytosis and proper pancreatic acinar cell function, controlled in part by pumps that shuttle Ca 2+ out of the cytosol. Our laboratory identified a novel ...
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Role of the Transcription Start Site Core Region and Transcription Factor YY1 in Rous Sarcoma Virus Long Terminal Repeat Promoter Activity
... transcription start site core (TSSC) ...binding site reduced RSV transcriptional activity by more than 50%, suggesting that YY1, in addition to other TSSC-binding factors, regulates RSV ...
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Efficient transcription from the rice tungro bacilliform virus promoter requires elements downstream of the transcription start site.
... ment is probably due to translational effects (14), but our ongoing work has revealed that this region also affects tran- scription (unpublished data). CT- or GA-rich regions can be found in the vicinity of the ...
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A cis Repression Sequence Adjacent to the Transcription Start Site of the Human Cytomegalovirus US3 Gene Is Required To Down Regulate Gene Expression at Early and Late Times after Infection
... Since the genes immediately downstream of the MIE pro- moter are essential for efficient replication in cell culture and the US3 gene is nonessential, we elected to test the role of the CRS in controlling expression from ...
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Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.
... scription start site could cause additional cellular specificity, increase the strength of the promoter-enhancer unit located in the LTR, or provide a mechanism to broaden the viral re- sponse to ...
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dKDM5/LID regulates H3K4me3 dynamics at the transcription start site (TSS) of actively transcribed developmental genes
... H3K4me3 is a histone modification that accumu- lates at the transcription-start site (TSS) of active genes and is known to be important for transcription activation. The way in which H3K4me3 is regulated at ...
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Varicella-Zoster Virus Gene 21: Transcriptional Start Site and Promoter Region
... ganglia (9, 32). Like the promoter for VZV gene 21, the VZV gene 29 promoter is silent in uninfected cells but is transacti- vated by VZV IE62 (33, 34). VZV IE62 is a promiscuous transactivator that recognizes numerous ...
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Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site.
... Given the idea that upstream regions of IE genes contain sequences which respond to viral and perhaps cellular 40 trans-acting factors, a different approach was used to systematically se[r] ...
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Control elements situated downstream of the major transcriptional start site are sufficient for highly efficient polyomavirus late transcription.
... To make RNA quantification easier, the probe used had to fulfill two conditions: it had to lie upstream of the splice donor as well as downstream of the major initiation start sites, to [r] ...
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Shared promoter elements between a viral superantigen and the major histocompatibility complex class II-associated invariant chain.
... transcriptional start site of this novel env promoter, we carried out primer extension ...identified start sites (Fig. 3A) in relation to the BglII site in the 3 9 end of the env gene, ...
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The Epstein-Barr virus (EBV) BMRF1 promoter for early antigen (EA-D) is regulated by the EBV transactivators, BRLF1 and BZLF1, in a cell-specific manner.
... Construction of in vitro site-directed mutations in pEA-CAT Plasmid Altered sequences relative to mRNA start site Mutations pEAA&AP1-CAT -57 to -63 TGACTCA- TCAGCTG pEAAZA1-CAT -240 to -[r] ...
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Biological Chemistry The Core Promoter and Redox-sensitive Cis -elements as Key Targets for Inactivation of the Lysyl Oxidase Gene by Cadmium
... Acetylation of histone N-terminal lysines is intimately linked to chromatin remodeling for transcription regulation. Reversible acetylation of histones such as H3 facilitates access of transcriptional machinery to DNA. ...
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MIEN1 is tightly regulated by SINE Alu methylation in its promoter
... pre-transcription start site region and a translation start site region (Figure 1A), which all contained potential methylation CpG sites, in detail in immortalized normal prostate epithelial ...
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A novel cis element essential for stimulated transcription of the p41 promoter of human herpesvirus 6.
... In addition to a single transcriptional start site and a functional TATA element, the p41 promoter was shown to contain a novel 21-bp element that is critical for transcriptional activit[r] ...
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Interaction of the HeLa cell protein EBP1 with viral and cellular enhancers
... binding site closest to the transcription start site has the greatest influence on activation of RNA synthesis for a given direction of transcription, suggesting that the functional directionality of ...
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Relationship between Retroviral DNA Integration and Gene Expression
... Integration within the coding region. The region down- stream of the transcription start site also showed a decrease in integration in the presence of the E2 protein, but only in our wt subclones. This ...
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Cloning and Promoter Identification of Acetoacetyl-CoA Thiolase Gene from Oil Palm, Elaeis guineensis Jacq.
... When these bases differ from the consensus sequence, part of the 40S ribosome subunit is unable to identify the ATG codon as the translation start site thus lower the rate of polypeptide synthesis. In 2008, ...
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Delineation of cis-acting sequences required for expression of Drosophila mojavensis Adh-1.
... Adh expression (SHEN et a l. The control regions of the D. Two of these are located in the region immediately upstream of the transcription start site and the third is [r] ...
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Noncanonical TATA Sequence in the UL44 Late Promoter of Human Cytomegalovirus Is Required for the Accumulation of Late Viral Transcripts
... distinct start sites were de- tected 2 and 3 days after infection with wt-R ...at start site 1 or 2 consisted of a doublet start ...of start site 2 was detected with TATAmut in ...
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Molecular analysis of an enhancin gene in the Lymantria dispar nuclear polyhedrosis virus.
... transcriptional start site of the LdMNPV enhancin transcripts, primer extension reactions were per- formed with an 18-base oligonucleotide that is complementary to nucleotides 132 to 149 within the enhancin ...
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