STAT proteins
Stat proteins and oncogenesis
... of Stat proteins’ key role in IFN signaling, initially described over ten years ago, provided the first molecular link of growth factor receptor stimulation to the direct activation of a transcription ...
5
Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium
... The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation and regression. These processes are under the control of the hormones secreted during pregnancy, lactation and involution. ...
5
Phosphorylation of STAT proteins by recombinant human IL-6 in immortalized human chondrocyte cell lines, T/C28a2 and C28/I2
... caused STAT proteins to be ...of STAT protein activation. These findings showed that rhIL-6 activated STAT proteins in the C28/I2 chondrocyte cell ...line. STAT protein ...
8
Stat proteins as intracellular regulators of resistance to myocardial injury in the context of cardiac remodeling and targeting for therapy
... of STAT (signal transducers and activators of transcription) proteins are widely discussed in relation to other agents like IFN-γ that are involved in cardiovascular ...of STAT proteins in ...
6
Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation
... and STAT proteins by electro- phoretic mobility shift ...and STAT proteins was assessed directly by immunoprecipitation and immunoblotting with an antiphosphotyrosine ...
5
Composition and Assembly of STAT-Targeting Ubiquitin Ligase Complexes: Paramyxovirus V Protein Carboxyl Terminus Is an Oligomerization Domain
... in STAT targeting by VDC has not been reported. The STAT proteins targeted by rubulaviruses are highly homologous to one another, and the Rubulavirus V proteins themselves are also very ...
10
JAK STAT signaling in asthma
... IL-12–treated Th1 cells (19, 25), allowing it (like Stat6) to control Th proliferation as well as differentiation. As with Th2 cytokines, induction of Th1-specific cytokine gene expression requires epigenetic remodel- ...
6
The dynamic changes of interferon lambdas related genes and proteins in JAK/STAT pathway in both acute and chronic HIV-1 infected patients
... IFN-α and IFN-β are main type I interferons, 12 closely related genes encode IFN-α. IFN-γ is the sole type II interferon. In 2003, type III IFNs which include three IFN-lambdas genes were newly identified by two inde- ...
7
Selective STAT Protein Degradation Induced by Paramyxoviruses Requires both STAT1 and STAT2 but Is Independent of Alpha/Beta Interferon Signal Transduction
... )-induced STAT signal transduction pathway leading to activation of the ISGF3 transcription complex and subsequent antiviral responses is the target of viral pathogenesis ...for STAT protein degra- dation ...
9
A Positive Autoregulatory Loop of LMP1 Expression and STAT Activation in Epithelial Cells Latently Infected with Epstein-Barr Virus
... sustained STAT phosphorylation and activation in epithelial cells, we examined STAT activity in two sets of paired cell lines, HeLa, an EBV-converted HeLa cell line, HeLa-Bx1, the NPC-derived cell line ...
10
Series Introduction: JAK STAT signaling in human disease
... which STAT signals decay are also poorly understood, although some important regula- tors of this aspect of the pathway have been ...er-regulatory proteins (39) (some of which were recent- ly highlighted in ...
6
STAT inhibitors for cancer therapy
... (STAT) proteins are a family of cytoplasmic transcrip- tion factors consisting of 7 members, STAT1 to STAT6, STAT5a and STAT5b ...of STAT proteins by these tyrosine kinases causes their homo- ...
11
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development
... (STAT) proteins are latent transcription factors that become acti- vated by phosphorylation on a single tyrosine (near the carboxy-terminal of the molecule), typically in response to extracellular ligands ...
5
Human Parainfluenza Virus Type 4 Is Incapable of Evading the Interferon-Induced Antiviral Effect
... out STAT degradation. The V proteins encoded by the rubu- laviruses SV5, SV41, hPIV2, and MuV block IFN-induced signaling by targeting STAT1 or 2 for degradation (1, 8, 25, 32, 33, 49, 50, 53, ...tag. ...
13
The central role of SOCS 3 in integrating the neuro immunoendocrine interface
... associated proteins termed STATs for signal transducers and activators of tran- ...various STAT proteins. The dimerized STAT complexes translocate to the nucleus, where they transactivate ...
7
JAK/STAT signaling and human in vitro myogenesis
... that STAT signaling during myogenesis is similar in humans as to what has been described in ...JAK/ STAT signaling in human skeletal myogenesis; further mechanistic investigation is warranted to clearly ...
7
Hepatitis C Virus (HCV) Constitutively Activates STAT-3 via Oxidative Stress: Role of STAT-3 in HCV Replication
... Quantitative, real-time RT-PCR. Total RNA was extracted from HCV repli- con-containing cells (FCA4) as well as Huh-7 cells by using RNA STAT-60 (Tel-Test, Inc., Friendswood, Tex). HCV RNA was quantified by ...
12
Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling
... and STAT hyperphosphoryla- tion is a direct consequence of the resulting disruption of heterochromatin, which then causes global defects in gene regulation ...
13
Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway
... Cell culture, HCV protein expression, and cytokine treatment. The character- ization of continuous human cell lines, termed UHCV, which allow the tightly regulated expression of the entire HCV open reading frame, has ...
7
Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak Stat signaling and inhibits HCV RNA replication
... Figure 2 Nuclear translocation of STAT-GFP constructs. The S9-13 and R15-3 cell lines were transfected with IRF9, Stat1, or Stat2 GFP fusion constructs (-) and (+) IFN-a (1,000 IU/ml) and their nuclear ...
12