STAT signaling
Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats
... JAK/STAT signaling pathway was enhanced by IL-1β stimulation in primary chondrocytes, and ACT could inhibit the JAK/STAT signaling in a dose-dependent manner ...
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Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak Stat signaling and inhibits HCV RNA replication
... Stat2-GFP chimera proteins was efficient in the S9-13 cell line; however the nuclear localization of Stat1-GFP and Stat2-GFP did not occur in the R15-3 cells that pos- sess defective Jak-Stat signaling. ...
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Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen
... JAK/STAT signaling, but dally apparently plays a more significant role at this ...other signaling contexts (Baeg et ...JAK/STAT signaling in the ovary, though they might contribute in ...
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JAK/Stat signaling regulates heart precursor diversification in Drosophila
... Intercellular signal transduction pathways regulate the NK-2 family of transcription factors in a conserved gene regulatory network that directs cardiogenesis in both flies and mammals. The Drosophila NK-2 protein Tinman ...
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HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells
... In classical Hodgkin lymphoma (cHL) chemotherapeutic regimens are associated with stagnant rates of secondary malignancies requiring the development of new therapeutic strategies. We and others have shown that ...
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MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer
... JAK-STAT signaling is meant to be transient, and to ensure this there are various feedback mechanisms in place to halt the signaling process at various steps, including degradation of receptors, ...
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JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1
... JAK-STAT signaling pathways caused the inhi- bition of such cell-to-cell infection as well as the reversion of multiple HIV Env mu- tants that displayed differences in their abilities to bind to the CD4 ...
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DNA methylation controls the timing of astrogliogenesis through regulation of JAK STAT signaling
... the STAT binding element within the Gfap promoter was shown to inhibit the association of activated STATs with the glial promoter, thereby repressing transcription of the Gfap gene (Takizawa et ...JAK-STAT ...
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A Determinant of Sindbis Virus Neurovirulence Enables Efficient Disruption of Jak/STAT Signaling
... Jak/STAT signaling; however, the relevance of this signaling inhibition toward pathogenesis has not been ...Jak/STAT signaling were compared to determine whether the ability to inhibit ...
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Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling
... Drosophila STAT (Signal transducer and activator of transcription) (STAT92E) has also been shown to be involved in the maintenance of heterochromatin, but its relationship to the H1-Su(var)3-9 heterochromatin ...
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JAK STAT signaling in asthma
... Jak-Stat signaling cascade discussed else- where in this Perspective ...this signaling path- way, binding of a cytokine to its receptor leads to the activation of members of the JAK family of ...
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JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates
... JAK/STAT signaling cause Stat92E-dependent upregulation of integrin adhesion (Issigonis et ...JAK/ STAT signaling in CySCs endows them with the ability to support (not outcompete) GSCs ...
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Requirement for JAK/STAT signaling throughout border cell migration in Drosophila
... reduced STAT activity (dome mosaic clones, overexpression of dominant-negative Dome, and overexpression of SOCS) lead to disruptions of cluster formation (Ghiglione et ...JAK/STAT signaling helps to ...
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Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats
... Abstract: Sitagliptin, a dipeptidyl peptidase-4 inhibitor, has been reported to promote cardioprotection in diabetic hearts by limiting hyperglycemia and hyperlipidemia. However, little is known about the involvement of ...
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An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans
... for STAT signaling in antiviral defense in ...both STAT homologs were no more permissive than sta-1 single mutants ...elegans STAT transcription factor STA-1 as acting in addition to the ...
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JAK/STAT signaling and human in vitro myogenesis
... intracellular signaling pathways and mole- cules have been found to play several roles in myogenic ...JAK/STAT signaling cascade also appears to be an integral factor for myoblast development, known ...
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Feifukang ameliorates pulmonary fibrosis by inhibiting JAK STAT signaling pathway
... molecular signaling pathway remains intractable because the potential targets and active substances of herbs are difficult to identify and analyze [37, ...and signaling pathways in FFK treatment were ...
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Series Introduction: JAK STAT signaling in human disease
... which STAT signals decay are also poorly understood, although some important regula- tors of this aspect of the pathway have been ...of STAT proteins ...
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JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila
... conserved signaling molecules regulate regional specification, in which uniform populations of cells acquire differences and ultimately give rise to distinct ...(Wg) signaling defines the region that gives ...
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CP690,550 inhibits oncostatin M induced JAK/STAT signaling pathway in rheumatoid synoviocytes
... ERK1/2 signaling led to partial reduction of the OSM-induced IL-6 secretion without affecting cellular viability which was checked by trypan blue exclusion test showing that >95% of cells that were treated with ...
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