STAT3/JAK2 Signal Pathway
Induction of metastatic potential by TrkB via activation of IL6/ JAK2/STAT3 and PI3K/AKT signaling in breast cancer
... signaling pathway have remained ...MAP/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK cascades through both focal adhesion kinase (FAK)-dependent and FAK-independent pathways ...signaling ...
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Original Article Protective effect of apigenin against myocardium injury in ischemia reperfusion rats by stimulating JAK2/STAT3 signal pathway
... of JAK2 and STAT3 was further strengthened by apigenin (2, 4 mg/kg/) in a dose-dependent ...stimulating JAK2/STAT3 signal pathway, decreasing oxidative ...
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Bacterial Lipopolysaccharide Vigorously Activate JAK2/STAT3 Induced Rheumatoid Arthritis Collate with Complete Freund's Adjuvant in Experimental Rats
... on JAK2/STAT3-induced RA, compared to the traditional Complete Freund’s Adjuvant (CFA)-induced ...phosphorylated JAK2 and STAT3, while serum samples used for biochemical evaluation of ...
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Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway
... despite STAT3 (signal transducer and activator of transcription 3), JAK2 was also a target of miR-337-3p, overexpression of miR-337-3p greatly downregulated JAK2, STAT3 and ...
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A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma
... GPC3 pathway by which the proliferation of HCC cells is ...SMC4. JAK2/Stat3 was identified as the tar- get of SMC4. JAK2, a member of the Janus (JAK) family of non-receptor protein tyrosine ...
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Original Article Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in bladder cancer
... that signal through JAK-STAT pathway or through receptor protein tyrosine kinase (RPTK) ...on JAK2 and blocks substrate association ...attenuate signal responses to cytokines and growth ...
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Original Article The JAK2/STAT3 pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats
... and signal transducer and activator 3 of transcription (JAK2/STAT3) signaling pathway participates in the neuroprotective effects of ...of JAK2/ STAT3 signaling ...
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Original Article IL-9 promotes proliferation and metastasis of hepatocellular cancer cells by activating JAK2/STAT3 pathway
... kinases/ signal transducer and activator of transcription 3 (JAK/STAT3) pathway is involved in the patho- genesis of different types of solid tumor [4, ...JAKs, STAT3 translocate to nucleus ...
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The mechanism and tumor inhibitory study of Lagopsis supine ethanol extract on colorectal cancer in nude mice
... of STAT3 and JAK2 compared to un- treated cells ...of STAT3 and JAK2 were normalized to the total relevant proteins (STAT3 and JAK2 respectively, ...of STAT3 and ...
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S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells
... JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2), are selec- tively associated with the cytoplasmic domains of various cytokine receptors ...the JAK2 pathway may result in a substantial increase in ...
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Original Article Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway
... of STAT3 signal related ...in JAK2/STAT3 signaling, while MMP- 2 and MMP-9 proteins levels were decreased and protein expression of VEGF and VEGFR-2 were ...in JAK2/ ...
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Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
... Currently, existing studies on anlotinib mostly focused on the antiangiogenic role and induction of tumor cell apoptosis [5, 7, 25], and data demonstrated that the effects of anlotinib on autophagy are still rare. In ...
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Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... signaling pathway are involved in immune response, inflammatory reaction, fat metabolism, and other processes ...JAK-STAT pathway may induce a variety of inflammatory diseases ...the ...
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Original Article Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway
... (JAK/STAT) pathway is a stress- responsive mechanism that has been implicat- ed in variety of cardiac pathophysiologic pro- cesses including hypertrophy, apoptosis, oxida- tive stress, myocardial interstitial ...
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The role of the JAK2-STAT3 pathway in pro-inflammatory responses of EMF-stimulated N9 microglial cells
... The signal transduction mechanisms involved in microglial activation and neuroinflammatory factors release after EMF exposure are still largely ...tical pathway that plays an important regulatory role in ...
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Scutellarin protects human retinal pigment epithelial cells against hydrogen peroxide (H2O2)-induced oxidative damage
... of JAK2/STAT3 signaling ...the JAK2/STAT3 signaling pathway ...a STAT3 signal pathway ...enhancing JAK2/STAT3 pro-survival signaling ...the ...
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Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway
... the JAK2-STAT3 signal- ing pathway have been shown by several studies in ...activated STAT3 after reperfusion and AG490 attenuated the anti-apoptotic effect of ...required STAT3 ...
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<p>STIP1 Regulates Proliferation and Migration of Lung Adenocarcinoma Through JAK2/STAT3 Signaling Pathway</p>
... The JAK2/STAT3 signaling pathway is known to regulate epithelial cell – cell adhesion and is closely related to the occurrence of EMT in malig- nant ...this pathway in fl u- ences tumor cell ...
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Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway
... Rats were killed and fresh brain-tissue samples collected 2 hours after CPB (n = 8). Hippocampal tissue samples were harvested to determine JAK2, pJAK2, STAT3, pSTAT3, and cleaved caspase-3 protein levels. ...
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Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.
... the JAK2 promoter region identified a possible BCL6 binding site at ⫺ 1185 bp from the transcription start site ...labeled JAK2 promoter BCL6 binding sequence (J2B6BS) oligonucleo- ...the JAK2 ...
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