STAT3 protein
Long non-coding RNA MEG3 inhibits cervical cancer cell growth by promoting degradation of P-STAT3 protein via ubiquitination
... P-STAT3 protein to affect its stability is ...P-STAT3 protein in cervical cancer cell lines and exert its regula- tory ...P-STAT3 protein (to achieve its regulatory function) was ...
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Original Article Curcumin inhibited the growth, invasion and migration of glioma U251 cells and induced apoptosis in U251 cells
... the STAT3 signaling pathway is overex- pressed in both primary and tumor ...of STAT3 plays an important role in the regulation of biological functions such as proliferation and apoptosis of tumor ...of ...
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Original Article Interleukin-22 promotes macrophage M2 polarization via STAT3 pathway
... of STAT3, p-STAT3 was detected by ...p-STAT3 protein was increased significantly, but STAT3 did not change ...of protein of STAT3 and p-STAT3 did not change ...
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<p>Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer</p>
... As stated before, USP28 mediated STAT3 signaling by stabi- lizing STAT3 protein, which suggested that USP28 was func- tional in NSCLC cells. First, the public database The Cancer Genome Atlas ...
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STAT3 expression correlates with prognosis of thymic epithelial tumors
... of STAT3 protein in ...of STAT3 protein in oncogenesis and development of TET and its potential value as a parameter in molecular biology in diagnosis of ...of STAT3 protein ...
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miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer
... assays, STAT3 was shown to be a direct target of miR-874. Overexpression of STAT3 rescued the loss of tumor angiogenesis caused by ...the STAT3-shRNA attenuated the increased tumor angiogenesis ...
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STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer
... on STAT3 during transformation, we performed microarray analysis in TAM-treated cells in which STAT3 protein (Figure 3A) and RNA levels were reduced more than 10-fold using siRNA (Additional file 1: ...
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STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
... This may be especially important 9 for in vitro STAT3 assays because recombinant STAT3 protein is known to be poorly soluble, unstable 10 and difficult to work with.16 In commonly used S[r] ...
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<p>L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway</p>
... inhibited STAT3 phosphorylation in PANC-1 ...inhibited STAT3 phosphorylation in PANC-1 (B) and BXPC-3 (C) human pancreatic cancer cells for 24 h; napabucasin is 5 ...of STAT3 SH2 (protein ...
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Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network
... tumor. STAT3 transcription factor is frequently activated in cell lines and leukemic blasts of patients with acute lym- phoblastic leukemia (ALL) or acute myeloid leukemia (AML) (Spiekermann et ...Moreover, ...
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Original Article Protective effects of calycosin weakens coronary heart disease-induced inflammation in a pig model
... of STAT3 protein expression in CHD of pig ...p-STAT3 protein expression by western blotting assays (A) and statistical analysis of p-STAT3 protein expression (B) in CHD of pig ...
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Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain
... of STAT3-YF and WT-STAT3 also play an essential role for the dominant-negative ...preformed STAT3 dimers in non-stimulated cells [8]. As shown here STAT3-YF-ΔN-YFP forms dimers neither in ...
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The Epstein-Barr virus latent membrane protein 1 regulates gene expression by engaging multiple signaling pathways
... mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), phosphatidylinositol 3-kinase (PI3K)-Akt, and NF-κB pathways (77, 239, 290, ...interacting protein (RIP), and BS69 (159, ...
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An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway
... a STAT3-targeted drug screen. SC09 suppressed the activation of STAT3 in a time-course and concentration- dependent manner but did not affect its family members STAT1 and ...inhibited STAT3 ...
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Original Article Effects of fallopian tube recuperation soup on JAK2/STAT3 pathways in rats with tubal infertility
... According to Traditional Chinese Medicine [10], salpingitis-induced infertility is mainly caused by stasis of uterine vessels and accumulation of ‘damp toxins’. In addition, Traditional Chinese Medicine has some ...
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Hepatocyte specific mutation of both NF κB RelA and STAT3 abrogates the acute phase response in mice
... We hypothesized that changes in circulating liver-derived proteins augmented macrophage opsonophagocytosis (5, 17). Serum from infected control mice significantly enhanced phagocytosis compared with that from uninfected ...
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Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
... studies have employed the inhibition of STAT3 as a beneficial anticancer strategy to target human tumors of both solid and hematologic origin [24]. Recently, NP has been used to target numerous malignancies. Our ...
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Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling
... and STAT3 after 24 hours of treatment with 2 μM and 4 μM ...activated STAT3 using gray analysis. (C) Immunoblot analysis of p-STAT3 and STAT3 after 24 and 48 hours of treatment with 4 μM ...
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Mitochondrial Stat3, the Need for Design Thinking
... of Stat3. JSI-124 or cucurbitacin I inhibits Stat3 phosphorylation by suppressing levels of Janus ki- nases and also activities of Janus kinases ...a Stat3 dependent manner, and subsequently, down- ...
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Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice
... for Stat3-dependent, tumor-derived MDSC–mediated angiogen- ...(D) Stat3 activity in tumor-associated myeloid cells contributes to elevated expression of multiple angiogenic ...factors. Stat3 +/+ and ...
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