STAT3 signaling
Original Article IL-6/STAT3 signaling pathway is activated in plasma cell mastitis
... of STAT3 [15, 20]. IL-6/STAT3 signaling pathway can promote the differentiation of plasma cells and inhibit apoptosis [16, 17, ...IL-6/STAT3 signaling in ...of STAT3, was ...
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Original Article Circulating levels of molecules associated with JAK2/STAT3 signaling pathway in patients with acute pancreatitis
... JAK2/STAT3 signaling pathway in humans with acute pancreatitis (AP) is yet ...JAK2/STAT3 signaling pathway including serum free fatty acid (FFA), leptin, p-JAK2, and p-STAT3 were ...
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Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
... activate STAT3 signaling and promote EMT, invasion, and ...inhibited STAT3 signaling in a dose-dependent ...of STAT3 in PATU-8988 ...of STAT3 was not changed after treatment with ...
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<p>Negative regulators of STAT3 signaling pathway in cancers</p>
... decrease STAT3 activity in non-Hodgkin's lymphoma cells with loss of ...block STAT3 activity and suppress sorafenib-resistant HCC- cell growth through promoting SHP1 ...
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Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth
... A STAT3-specific transcription factor decoy has been developed to suppress STAT3 downstream signaling, but a delivery strategy is needed to improve clinical ...deliver STAT3 decoy to squamous ...
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Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway
... To sum up, the current study evidenced that exosomes de- rived from AML cells carrying miR-4532 exert a suppressive effect on hematopoiesis of HSCs by the LDOC-dependent STAT3 signaling pathway, which ...
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Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells
... Notch signaling may play certain favourable roles in the two cell ...used, STAT3 phosphorylation and nuclear translocation in HeLa and SiHa cells were successfully ...inhibited signaling pathways so ...
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Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma
... At present, our results first indicated that the CLDN17 was overexpressed and highly associated with metastatic progression and prognosis in patients with HCC. More- over, the overexpression of CLDN17 markedly promoted ...
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A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway
... of STAT3. This downregulation thereby inhibited JAK2- STAT3 signaling and was the proposed mechanism for how AA-PMe inhibited gastric cancer cell ...inhibit STAT3, block JAK2-STAT3 ...
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Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation
... responses, STAT3 has been found to be the target of some viral ...IL-6-mediated STAT3 signaling ...inducing STAT3 ubiquitination and degradation ...receptor signaling by interacting ...
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Dystrophy associated caveolin 3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
... Next, we examined whether the reconstitution of the caveolae reservoir at the plasma membrane of Cav3 P28L myotubes was sufficient to rescue the regulatory role of caveolae in mechan- oprotection and IL6/STAT3 ...
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Lnc-DC regulates cellular turnover and the HBV-induced immune response by TLR9/STAT3 signaling in dendritic cells
... TLR9/STAT3 signaling in dendritic cells. The correlation between Lnc-RNAs and STAT3 signaling has been described in multiple tumor cells ...TLR9/STAT3 signaling. Lnc-DC knockdown ...
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2 Ethoxystypandrone, a novel small molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells
... IL-6/STAT3 signaling were determined by STAT3-dependent luciferase reporter assay described in our previously report [14, ...a STAT3-responsive firefly luciferase reporter plas- ...
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CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2/STAT3 signaling in human non-small-cell lung cancer cells
... of CXCL12 in the NSCLC tumor tissues was significantly correlated with tumor classification, lymph node metastasis, stage, and tumor size. These results suggest that CXCL12 may contribute to tumor progression and ...
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Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway
... that STAT3–DNA binding was inhibited by the treatment with AT-101 alone or combined with CDDP, but that the latter was more ...IL-6/STAT3 signaling pathway in A549 ...IL-6/STAT3 ...
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Original Article Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling
... Abstract: Glycyrrhizic acid (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti-cancer, and anti-inflammatory properties. This study was designed to ...
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STAT3 Signaling in Cancer
... MEK-ERK signaling has been shown to drive Ras-induced phosphorylation of STAT3 on Ser727 and mitochondrial STAT3 is a crucial substrate of the Ras-MEK-ERK pathway during cellular transformation ...
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<p><em>NETO2</em> promotes pancreatic cancer cell proliferation, invasion and migration via activation of the <em>STAT3</em> signaling pathway</p>
... the STAT3 signaling pathway through promotion of STAT3 phos- ...of STAT3 induces the interaction of the SH2 domain and phos- photyrosine, thereby causing STAT3 dimerization and the ...
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Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
... of STAT3 signaling with the effect on STAT3 phosphorylation and/or STAT3- STAT3 dimerization inhibition, as summarized in Table ...of STAT3-SH2 domain [139, ...the STAT3 ...
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Original Article Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway
... A growing number of studies have intensively investigated reactive oxygen species (ROS) to reveal their role in MI/R injury, ranging from beneficial to inimical [39, 40]. When the bal- ance between the production and ...
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