Stearoyl-CoA
An Evolutionary Relationship Between Stearoyl-CoA Desaturase (SCD) Protein Sequences Involved in Fatty Acid Metabolism
... Stearoyl-CoA desaturase is the rate-limiting enzyme that introduces the first cis-double bond at the delta-9 position of saturated fatty acids (SFAs) to thereby generate monounsaturated fatty acids (MUFAs) ...
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Critical role of stearoyl CoA desaturase–1 (SCD1) in the onset of diet induced hepatic insulin resistance
... acyl- CoA; OF, overfed, overfeeding; p, phosphorylated; PEPCK, phosphoenolpyruvate car- boxykinase; PTP1B, protein tyrosine phosphatase 1B; Q-PCR, quantitative real-time PCR; SC, standard chow; Scd1, ...
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Stearoyl-CoA desaturase indexes and n-6/n-3 fatty acids ratio as biomarkers of cardiometabolic risk factors in normal-weight rabbits fed high fat diets
... as stearoyl-CoA desaturases, SCD) catalyze the rate limiting step in the conversion of saturated (SFA) to monounsatu- rated fatty acids (MUFA) (mainly oleic acid [OA, 18:1 n-9] and palmitoleic acid [16:1 ...
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Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells
... the stearoyl- CoA desaturase catalyses the transformation of stearic acid into oleic acid and trans-11 vaccenic acid into cis-9 trans- 11 conjugated linoleic acid (Pollard et ...
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Hepatic and plasma sex differences in saturated and monounsaturated fatty acids are associated with differences in expression of elongase 6, but not stearoyl-CoA desaturase in Sprague–Dawley rats
... Abstract Monounsaturated fatty acids (MUFA) have been viewed as either beneficial or neutral with respect to health; however, recent evidence suggests that MUFA may be associated with obesity and cardiovascular disease. ...
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Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells
... RCT begins with cholesterol export across the cyto- plasm membrane, a process known as cholesterol efflux. Our previous study showed that the omega-3 PUFA ALA significantly decreases cholesterol storage and increases ...
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One-night sleep deprivation induces changes in the DNA methylation and serum activity indices of stearoyl-CoA desaturase in young healthy men
... enzyme stearoyl-CoA desaturase (SCD), which is predominantly expressed in the liver, plays a central role in the desaturation of saturated fatty acids (FAs), thus having important implications in the ...
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Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma
... their survival [22 – 24]. Recently, we and others have reported that CSCs maintenance is due to an altered metabolic status, characterized by a larger pool of mono- unsaturated fatty acids (MUFAs), generated by the ...
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Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes
... JM: Stearoyl-CoA desaturase and its relation to high- carbohydrate diets and ...between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse ...
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Overexpression of stearoyl-CoA desaturase 1 in bone marrow mesenchymal stem cells enhance the expression of induced endothelial cells
... 12. Liew CF, Groves CJ, Wiltshire S, Zeggini E, Frayling TM, Owen KR, Walker M, Hitman GA, Levy JC, O ’ Rahilly S, Hattersley AT, Johnston DG, McCarthy MI: Analysis of the contribution to type 2 diabetes susceptibility ...
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Stearoyl-CoA Desaturase-1 Is Associated with Insulin Resistance in Morbidly Obese Subjects
... Animal studies have revealed the association between stearoyl-CoA desaturase 1 (SCD1) and obesity and insulin resistance. However, only a few studies have been undertaken in humans. We studied SCD1 in ...
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Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet
... the stearoyl-CoA desaturase 1 (SCD-1) product ...(18:3n-6/18:2n-6), stearoyl-CoA desaturase 1 (SCD-1; 16:1n-7/16:0, SCD-16 and 18:1n-9/18:0, SCD-18), de novo lipogenesis (16:0/18:2n-6) and FA ...
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Regulation of mammary stearoyl CoA desaturase and the effects on milk fat composition in lactating mice : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Human Nutrition at Massey University, Palmerston North, New Zealand
... The effect of control, fat free and clofibrate diets on stearoyl-CoA desaturase mRNA levels in liver and mammary gland of lactating mice.. The effect of control, fat free and clofibrate [r] ...
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Probing the role of stearoyl CoA desaturase–1 in hepatic insulin resistance
... using stearoyl-CoA desaturase–1–deficient (SCD1-defi- cient) mice have shown that this enzyme plays an important role in many diseases of altered cellular metabolism including obesity, insulin resistance, ...
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Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl CoA desaturase–1
... Nonstandard abbreviations used: ACC1, acetyl-coenzyme A carboxylase 1; ACO, acyl-CoA oxidase; ASO, antisense oligonucleotide; ASOctrl, control ASO; β3-AR, β3-adrenergic receptor; BAT, brown adipose tissue; FAS, ...
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Regulation of mammary stearoyl CoA desaturase and the effects on milk fat composition in lactating mice : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Human Nutrition at Massey University, Palmerston North, New Zealand
... The correlation of liver SCD rnRNA and the 16:1/16:0 and 18:1/18:0 FA ratios for milk, liver and mammary gland tissue of lactating mice within the injected treatments.. The correlation o[r] ...
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Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the <em>FTO </em>gene
... Within the human liver, the acetyl-CoA subunits, originat- ing mostly from dietary carbohydrates, are the precursors of cholesterol from where CDCA and CA are synthesized, and also precursors of the components of ...
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Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN
... Taken together, our results indicate that SCD1, via MUFA, suppress the expression of PTEN and activity of Akt, promoting the migration and invasion of colorectal cancer cells.. Discussio[r] ...
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Downregulation of CPT2 promotes tumorigenesis and chemoresistance to cisplatin in hepatocellular carcinoma
... of stearoyl-CoA desaturase-1, the key enzyme involved in the synthesis of monounsaturated fatty acids, at both mRNA and protein levels in hepatoma cell ...
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Metabolic transition of milk triacylglycerol synthesis in response to varying levels of palmitate in porcine mammary epithelial cells
... ACACA: Acetyl-CoA carboxylase 1; ACSL3: Acyl-CoA synthetase long-chain family member 3; ACSS2: Acyl-CoA synthetase short-chain family member 2; AGPAT1/6: 1-Acylglycerol-3-phosphate O-acyltransferase ...
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