steroid 5-alpha reductase
Genetic and pharmacological evidence for more than one human steroid 5 alpha reductase
... enzyme steroid 5 alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone, and impairment of this reaction causes a form of male ...
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Molecular genetics of steroid 5 alpha reductase 2 deficiency
... The 5 alpha-reductase type 2 gene (gene symbol SRD5A2) was cloned and shown to contain five exons and four ...with 5 alpha-reductase ...
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Tissue distribution and ontogeny of steroid 5 alpha reductase isozyme expression
... with 5 alpha-reductase type 1 being responsible for virilization in type 2-deficient subjects during puberty, and suggest that the type 2 isozyme may be an initiating factor in development of male ...
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Review Article Association between steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and prostate cancer risk: a meta-analysis study
... with 5 exons and 4 introns, and several common single nucleo- tide polymorphisms (SNPs) on the coding gene have been identified including V89L, A49T, R227Q the (TA)n dinucleotide repeat in the 3’-UTR ...
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Oxidative stress in prostate hyperplasia and carcinogenesis
... 1, alpha subunit (HIF1A) encodes the alpha subunit of transcription factor hypoxia- inducible factor-1 (HIF-1), which is a heterodimer consist- ing of an alpha and a beta ...[126]. ...
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A Review on Finasteride: A 5-Alpha Reductase Inhibitors, its Mechanism, Facts and Benefits
... 5á- reductase enzymes and the subsequent restoration of 5á- reduced steroid metabolite levels following the cessation of finasteride treatment in ...
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Induction of a deficiency of steroid delta 4 5 alpha reductase activity in liver by a porphyrinogenic drug
... and steroid 5alpha-reduction in man were examined to determine if this drug could produce changes in steroid 5alpha-reductase activity which mimicked those seen in patients with acute intermittent ...
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The role of 5 alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme?
... somatic 5-AR mutations in human prostate cancer tissue have implications both in the predisposition and in the progression of prostate ...activated steroid andro- gen receptor, while only 7% had SRD5A2 ...
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Role of 5 alpha-reductase inhibitors in the management of prostate cancer
... its steroid structure, it has no affinity for any steroid receptors, including androgens, estrogens, and progesterone (Stoner 1992), allowing the inhibition of 5AR without concomitant binding at other ...
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Underlying Genetic Defects in Diseases of Sexual Development in the Island of Cyprus Support the Founder Effect
... the 5-alpha Steroid Reductase Deficiency (5αSRD) IVS1-2A>G mutation and the carrier frequency of 17-beta Hydroxysteroid Dehydrogenase 3 (17β-HSD-3) ...
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Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei
... Cells were lysed in hypertonic buffer containing 50 mM Tris, pH 7, 50 mM NaCl, 0.1% NP40, a protease inhibitor cocktail (Roche Diagnostics), and 1 mM DTT. Each cell lys- ate was separated via electrophoresis in a 10 or ...
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Pre Androgen Ablation Prostate Cancer Patients Who Bleed Do Well with 5 Alpha Reductase Inhibitors
... a 5 alpha reductase inhibitor like dutasteride has been found helpful in bleeding prostate cancer patients if they have not undergone hormonal manipulation before they developed ...
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High dose androgen therapy in male pseudohermaphroditism due to 5 alpha reductase deficiency and disorders of the androgen receptor
... have 5 alpha-reductase deficiency, and two have defects of the androgen receptor (the Reifenstein ...with 5 alpha-reductase deficiency and one man with the Reifenstein syndrome ...
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Impact of 5-Alpha Reductase Inhibitors Treatment for Benign Prostatic Hyperplasia on Erectile Dysfunction: A Meta-Analysis
... The randomized controlled trials that met the following criteria were included: (1) the study referred to the effect of 5α-reductase inhibitors on BPH; (2) the study for provided sufficient data for analysis, ...
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Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer
... rs1801133 and rs1801131 on toxicities of capecitabine therapy in patients with MBC, but found no such asso- ciations. This result was in agreement with those of some [34–36], whereas other studies have demonstrated sig- ...
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Alpha-substituted cystines as substrates for cystine reductase, and L-amino acid oxidase.
... T a b l e I V . Km a n d Vma x v a l u e s f o r t h e c y s t i n e r e d u c t a s e s y s t e m . A l l v a l u e s w e r e o b t a i n e d b y t h e m e t h o d o f L i n e w e a v e r a n d B u r k ( 6 4 ) , The d e ...
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Pyrroline 5 carboxylate reductase in human erythrocytes
... Pyrroline-5-carboxylate reductase, which converts pyrroline-5-carboxylate to proline, has been identified in human ...pyrroline-5-carboxylate reductase activity in these cells is ...
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A population-based study of polymorphisms in genes related to sex hormones and abdominal aortic aneurysm
... frequency >5% and r 2 >0.8) 10 . Regions analysed included the entire gene, plus additional sequences 10 kb upstream and downstream of the gene. With this approach 100% of the variation in the genes was ...
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<p>Integrative and Analytical Review of the 5-Alpha-Reductase Type 2 Deficiency Worldwide</p>
... with 5 α -RD2 de fi ciency (including hormonal data) with only a single SRD5A2 variant suggest that other mechanisms beyond SRD5A2 exonic sequences may play a role in this ...the 5 ʹ UTR region of the AR was ...
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Effect of prostatic inflammation on the outcome of patients with benign prostatic hyperplasia treated by transurethral resection of the prostate
... ABBREVIATIONS 5-ARI: Five alpha reductase inhibitor AIP: Asymptomatic inflammatory prostatitis BPH: Benign prostatic hyperplasia COAD: Chronic obstructive airway disease CPPS: Chronic pr[r] ...
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