steroid metabolism
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis.
... We performed a case-control study of Brazilian women to investigate the association of GSTP1 and CYP17 gene polymorphisms with breast and ovarian cancer, as well as with MSI/LOH in three genes implicated in ...
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Sex steroid metabolism polymorphisms and mammographic density in pre and early perimenopausal women
... The SWAN Genetics Study genotyped 25 SNPs relating to sex-steroid metabolism and estrogen receptors (Figure 1, Table 1). Of the 1,988 women who were eligible (that is, still participating and providing ...
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ADRENOCORTICAL STEROID METABOLISM AND ADRENAL CORTICAL FUNCTION IN LIVER DISEASE
... These patients thus had adrenal cortical insufficiency in terms of quantity of cortisol synthesized; however, they were essentially "eucorticoid" in terms of a plasma cortisol level main[r] ...
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Proteomic characterization of adrenal gland embryonic development reveals early initiation of steroid metabolism and reduction of the retinoic acid pathway
... the steroid biosynthetic process or sterol transporter activity, like Apoa1, Apoa4, Star, Fabp3 or Fabp6 were hardly expressed in early stage, whereas their expression increased in the course of development of the ...
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STUDIES IN STEROID METABOLISM XXVIII THE α KETOSTEROID EXCRETION PATTERN IN NORMAL FEMALES AND THE RESPONSE TO ACTH
... The chemical nature of the 11-desoxy steroid metabolites makes it likely that this alteration in adrenal function reflects the selective diminution in secretion of an "adrenal androgen."[r] ...
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STUDIES IN STEROID METABOLISM XIX THE a KETOSTEROID EXCRETION PATTERN IN NORMAL MALES
... The aqueous residue after ether extraction from Stage 2 was treated as in Method A, Stages 1, 2, 3, and 4, and a final "crude neutral fraction" was obtained.. This hydrolytic method yiel[r] ...
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STUDIES IN STEROID METABOLISM XXII THE ADRENAL RESPONSE TO ACTH IN YOUNG AND OLD MEN
... The adrenal response to continued daily intramuscular administration of ACTH, as measured by urinary steroid excretion, is in the most general terms characterized by a prompt stepwise in[r] ...
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Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin resistant women with the polycystic ovary syndrome
... 10 insulin-resistant women with PCO and 5 age- and weight-matched ovulatory normal women had pulsatile gonadotropin release, gonadotrope sensitivity to gonadotropinreleasing hormone, and[r] ...
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STUDIES IN STEROID METABOLISM XXVII A COMPARISON OF THE STEROID RESPONSE TO ACTH AND CORTISONE IN NORMAL YOUNG MEN
... This study deals with the isolation and quantitative estimation of urinary ketosteroids following the administration of adrenocorticotrophic hormone ACTH and cortisone acetate to two nor[r] ...
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Effect of Maternal Intrahepatic Cholestasis on Fetal Steroid Metabolism
... neutral steroid sulfates, including estriol precursors and progesterone metabolites, were determined in 27 cord plasma samples collected after pregnancies complicated by intrahepatic cholestasis of the ...the ...
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Studies in Steroid Metabolism XXVI Steroid Isolation Studies in Human Leukemia
... The detailed ketosteroid patterns of six subjects with chronic lymphatic leukemia during control periods and of one subject with acute myelogenous leukemia during a control interval and [r] ...
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Metabolic fate of pregnene-based steroids in the lactonization pathway of multifunctional strain Penicillium lanosocoeruleum
... 3β-hydroxy-5-en steroid) was transformed exclusively to testololactone with 3-oxo- 4-en functionality in ...determining steroid metabolism by this organism, the current study was initiated to delin- ...
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Male pseudohermaphroditism due to 17α hydroxylase deficiency
... of steroid metabolism including the following: low urinary excretion of 17-ketosteroids and 17- hydroxycorticoids which did not increase after ACTH; no response of very low plasma testosterone and ...
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Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors
... The WWOX gene alternatively knocked out in mice is commonly used to study the roles of WWOX in steroid metabolism. WWOX deficient mice are born with gonad abnormalities, including failure of Leydig cell ...
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Steroidogenic Enzymes and Stem Cell Markers Are Upregulated during Androgen Deprivation in Prostate Cancer
... the steroid metabolism simultaneous toward and away from the active steroids clearly indicates that this balance is controlled carefully in the tis- ...
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Steroids and Reproductive Biology in the Blotched Blue tongued Lizard, Tiliqua nigrolutea
... (extragonadal) metabolism of T and E2 in a number of reproductively relevant steroid target tissues is compared at times of year chosen to represent three clearly distinctive reproductive conditions in each ...
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Synthesis and Mass Spectrometry of Bisconjugate Phase II Steroids
... bisconjugated steroid metabolites have long been known as minor components of the steroid profile that have traditionally been studied by laborious and indirect fractionation, hydrolysis and gas ...
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Anti-interleukin-2 receptor antibodies—basiliximab and daclizumab—for the prevention of acute rejection in renal transplantation
... remain steroid-free two years postoperatively; however, they have higher incidence of immunological graft loss, chronic allograft nephropathy, and poor renal ...
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Cyclosporine A and steroid therapy in childhood steroid-resistant nephrotic syndrome
... We are interested mainly in the therapeutic response to CsA according to histological type and the fact that steroid resistance is initial or secondary. The statistical analysis was performed using the StatView ...
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STUDIES IN FAT METABOLISM III THE EFFECT OF ACTH, OF CORTISONE, AND OF OTHER STEROID COMPOUNDS UPON FASTING INDUCED HYPERKETONEMIA AND KETONURIA
... The blood ketone values during this fast were comparable to those during the period of "testosterone rebound." The blood sugars and the urinary nitrogens were slightly higher; and the ci[r] ...
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