sterol regulatory element 1
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
... (ADD) 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced dramatically upon fasting and elevated ...
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Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... Results: Compared with HepG2 cells cultured in normal growth medium, glucose production of HepG2 cells treated by FFA was significantly increased {[(0.28 ± 0.01) vs (0.83 ± 0.02)] umol.ug − 1 protein, n = 6 wells, ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid ...
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Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
... Plasmids, antibodies, and reagents. The pSynSRE-Luc plasmid containing three SREs ( ⫺ 325 to ⫺ 225 bp of the hamster high-mobility group [HMG] coenzyme A [CoA] synthase promoter fused into the luciferase pGL2), the JS-15 ...
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Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
... NK cells express a wide array of activating receptors, which recognise ligands abnormally induced on the surface of cells in response to stress or associated with pathogens. Examples of activating receptors expressed on ...
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Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... To date, in-depth characterizations of fungal SREBPs have been performed for S. pombe, C. neoformans, and A. fumigatus. However, many fungal species contain putative SREBPs and components of the SREBP pathway, including ...
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<p>Therapeutic targets of hypercholesterolemia: HMGCR and LDLR</p>
... kinase 1 (MEK1)/ERK-PCSK9 ...cAMP-responsive element binding protein (CBP) and early growth response gene 1 (Egr1) was required to bind to the sterol-independent regulatory ...
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Activation of sterol regulatory element binding protein 1 (SREBP1) mediated lipogenesis by the Epstein Barr virus encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma
... by sterol regulatory element-binding protein (SREBP) 1, a transcription factor that regulates the transcription of most genes involved in lipogenesis ...to sterol reg- ulatory elements ...
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Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... SREBP2/TFII-I pathway is critical for HIV-1 replication in primary CD4 ⴙ T cells. To demonstrate that SREBP2 and TFII-I are involved in HIV-1 replication in primary T cells, we knocked down expression of ...
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Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... The nuclear form of SREBP is rapidly degraded by the ubiquitin-proteasome pathway involving the SCF (Skp1–Cul1– F-box protein) ubiquitin ligase complex (21). Fbw7 is an F-box protein within the SCF modular complex which ...
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AMPK: A POTENT TARGET FOR TREATING OBESITY
... responsive element binding ...SREBP-1: sterol regulatory element binding ...Src 1: steroid receptor coactivator ...Cry 1: cryptochrome gene ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... SCAP is required for SREBP1 cleavage in HCMV-infected cells. The observation that the cleavage of SREBP1 in infected cells was insensitive to sterol levels led us to ask whether the virus cir- cumvents the normal ...
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... To determine whether the 1c:1a ratio might change during differentiation of cells in tissue culture, we studied 3T3-L1 cells, a subclone of 3T3 cells that can be induced to differenti- ate into adipocytes by treatment ...
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Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
... palmitoyltransferase 1 (CPT-1) are rate limiting enzymes in catabolism, responsible for hydrolysis of triglycerides and importing esters of fatty acids to mitochondria for b-oxidation ...Furthermore, ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... Nonalcoholic fatty liver disease (NAFLD) is the predom- inant cause of chronic liver disease. The incidence of NAFLD in the world is 25.24%, with a range of 13.5% in Africa to 31.8% in the Middle East [1]. NAFLD ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... protein 1 ( XBP-1 ) mRNA allows translation of this tran- scription factor and leads to expression of genes in- volved in degradation of misfolded proteins within the ER lumen ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... While mTORC1 is emerging as a key molecule for the control of T cell metabolism and function, the role played by mTORC1 in other lymphocyte subsets, in particular NK cells, has not been well defined. Therefore, very ...
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element binding protein 2
... In the Northern blotting experiment of Fig. 3, the livers of the line B mice contained about threefold more transgene SREBP-2 mRNA than the livers of the line A mice (Fig. 3, up- per left panel ). A similar trend was ...
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An in silico study on the interaction between RU486, a glucocorticoid antagonist and some regulatory proteins of lipid metabolism
... (PPARγ), sterol regulatory element-binding protein 1c (SREBP-1c), cluster differentiation 36 (CD36), acetyl-CoA Carboxylase (ACC), FASN, stearoyl-CoA desaturase-1 (SCD-1), liver X ...
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... reverse ch5’AS primer. The RT-PCR was followed by a nested PCR by means of the human forward hu5’UTRnS primer corresponding to nucleotides 62 to 84 of the 5’ UTR region and the reverse chicken ch5’nAS primer. The total ...
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