Sterol regulatory element-binding protein 2
Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... the sterol regulatory element-binding protein 2 (SREBP2) transcriptional program, which includes genes involved in cholesterol ...
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element binding protein 2
... of sterol regulatory element-binding protein-2 (SREBP-2) in liver and adipose ...coded protein lacks the membrane-binding and COOH-ter- minal ...
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Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... a sterol-independent mechanism for the reg- ulation of Sre1 ...the 2-oxo- glutarate Fe(II) dioxygenase domain-containing protein Ofd1 (20, ...the 2-oxoglutarate Fe(II) dioxygenase prolyl ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... cellular sterol level and requires expression of viral ...cellular sterol levels; cleavage is enhanced by sterol depletion and inhibited by sterol supplement (1, ...by sterol levels in ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... Several lines of evidence indicate the involvement of the Akt/mTORC1 signaling axis in the regulation of SREBP. We have shown that mTORC1 is required for the nuclear accumulation of mature SREBP1 in response to Akt ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... significantly different. Women with EC had a higher mean BMI (32.22 (±5.70) kg/m 2 ). SREBP1 gene expression was significantly increased in PCOS and EC endometrium compared to controls (p<0.0001). SREBP1 gene ...
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Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... Cells in 6-well plates were immediately washed with ice-cold PBS following treatment and lysed with 500 μL Tri- zol reagent (Invitrogen). Total RNA was extracted, Reverse transcription was performed with 460 ng total RNA ...
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... Chicken vs. human intron lengths are 77 bp vs. 84 bp and 117 bp vs. 85 bp for SREBP-1 introns 3 and 4, respectively, and 689 bp vs. 520 bp for SREBP-2 intron 8. However, intron 7 was found to be divergent in ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... the protein and mRNA levels of SREBP1c; 2) adenovirus or plasmid mediated overexpression of FoxO3 resulted in increased expression of SREBP1c; 3) SREBP1c expression was increased in the livers of ...
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Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
... by sterol regulatory element-binding transcription factors (SREBFs), which are transcription factors that modulate the transcription of genes involved in lipid and choles- terol ...In ...
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Activation of sterol regulatory element binding protein 1 (SREBP1) mediated lipogenesis by the Epstein Barr virus encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma
... EBV latently infected NPC cells and xenografts, in which LMP1 was expressed (Figure 2). Whereas nor- mal nasopharyngeal epithelium showed an absence of expression of FASN and LMP1 (Figure 4A), a high level of FASN ...
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Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
... FAS protein in HCV-infected cells, cel- lular lysates from cells infected with HCV were subjected to SDS-PAGE followed by Western blot ...SRE binding sites) luciferase plasmids along with plasmids ...
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p38 Mitogen-Activated Protein Kinase and Liver X Receptor-α Mediate the Leptin Effect on Sterol Regulatory Element Binding Protein-1c Expression in Hepatic Stellate Cells
... through binding to their bind- ing sites in the region of SREBP-1c pro- moter in hepatocytes ...Sp1 binding sites), plasmid pNFY-Luc (containing Figure ...SREBP-1c protein (B) and mRNA (C) levels, ...
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... mRNA-encoding sterol regulatory ele- ment binding protein-1 (SREBP-1) exists in two forms, des- ignated 1a and ...by regulatory regions that respond differentially to organ-specific and ...
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
... coding the 5 9 -untranslated region and amino acids 1–460 of human SREBP-1a cDNA and a 1.4-kb SalI fragment encoding the 5 9 -un- translated region and amino acids 1–436 of human SREBP-1c cDNA were each excised from the ...
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Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... in sterol biosynthesis ...different protein or mechanism in different fungal ...CoCl 2 , which is incon- sistent with the sensitive phenotype of all other Sre1 pathway ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... Numerous in vivo and in vitro studies have reported that tumour cells are recognized as NK cell targets (Trinchieri, 1989). Murine NK cells play a major role in the in vivo rejection of transplanted tumours, involving ...
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AMPK: A POTENT TARGET FOR TREATING OBESITY
... responsive element binding ...kinase 2. SD: succinate dehydrogenase. SREBP-1: sterol regulatory element binding ...
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
... 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced dramatically upon fasting and ...
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Sterol carrier protein-x gene and effects of sterol carrier protein-2 inhibitors on lipid uptake in Manduca sexta
... ing protein and SCP-2 desorbs the free lipids from the cytoplasm membrane and deliver them to the storage site or funnel them into a metabolic pathway ...bound protein [31], and ...
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